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Prevention of nasal polyposis
Nesvadbová, Martina ; Schalek, Petr (advisor)
Rhinosinusitis is a heterogeneous group of diseases, with different underlying etiologies and pathomechanisms, and may indeed represent an umbrella, covering different disease entities. It is currently not understood whether acute recurrent rhinosinusitis necessarily develops into chronic rhinosinusitis, which then possibly gives rise to polyp growth, or whether these entities develop independently from each other. Nasal polyposis is an inflammatory condition that affects from 1% to 4% of the general population. Polyposis is believed to be multifactorial disease that is frequently associated with asthma and aspirin sensitivity. The studies show that more polyps were found in nonatopic that in atopic patients. A global evaluation of NP must include, together with nasal endoscopy, symptoms assessment, and CT-scan, the measurement of the quality of life. In my study I used the Sino nasal outcome test (SNOT-22), with 22 questions to ask the patients about the quality of life. They were asked to fill up the questionnaire before and 6 month after the surgical procedure. Twelve patients were included to this study, than they were divided into two groups, patients with and without the factors of the risk (asthma, aspirin sensitivity and allergy). I compared the scores of two groups by using an impaired Student t...
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Most frequent problems of "flop" the high-jump practice in the school physical training
Voštiňák, Radek ; Engelthalerová, Zdeňka (referee) ; Kašpar, Ladislav (advisor)
The aim of this study is to determine the most frequent mistakes at practice of the high-jump in the school physical training. My work try to help with mistakes elimination via demonstration. This study should serve as a help for beginning teachers at the high-jump practice. I will identify the most frequent mistakes at the high-jump practice by the continuous testing of the chozen group of students from the primary school, concretely at the "flop" style. Based on this test I'll put together the most frequent mistakes chart and I'll try to contribute to their elimination by the special training. I'll use kinograms in the process of corrective training for better clearness. The result of this study shows that the better technique of the students high-jump is, the better achievement has been reached. I focused only on general and explicit mistakes at the formation of the mistake chart. But in fact there are many more mistakes done by the jumper. From results of my testing I can say that the older student is, the maximum jump high is. But, what I mainly observed and what had proved was, that the older students are, the less mistakes they did. That is the mark of the teachers correct approach and the right syllabus performance, where the athletics takes no small interest.
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Czech translation equivalents of English question tags of the same polarity
Vaňková, Lenka ; Malá, Markéta (referee) ; Šaldová, Pavlína (advisor)
The present study deals with English question tags of the same polarity and their Czech translation equivalents. It focuses on question tags from the point of view of their structure, formation, polarity and intonation and describes their various discourse functions. Since English question tags do not have an analogous construction in Czech, they provide an interesting construction for comparison. The discourse functions of the question tags differ according to the type of the main clause to which they are appended, i.e. declarative, imperative, interrogative or incomplete. These functions, together with the focus on the means of their translation into Czech, are analysed in detail in the empirical part of the study. As the question tags of the same polarity are not very frequent linguistic phenomenon, seventeen texts and their translations were needed to gather 102 instances by means of ParaConc, a parallel concordance software, and The British National Corpus.
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Antimicrobial effect of photocatalytically effective metal compounds.
Ľupták, Peter ; Vejsová, Marcela (referee) ; Jílek, Petr (advisor)
1 Abstract. ĽUPTÁK, P. Antimicrobial effect of photocalatic effective compounds of metals. Diploma work. Faculty of Pharmacy in Hradec Králové, Charles University, 2009. Field of study: Pharmacy, Background This diploma work is aimed at testing antimicrobial activity coatings on the basis of photocalytic effect of nano particles of metal dioxides. In the coats tested active nano particles of tantium dioxide alone or with zinc oxide were used. Methods In this work we have developed a methodics, which is in the experimental part. The methodics contains three ways, in which the coats have been mutually compared on the basis of activation of UV-VIS radiation: A method of in advance radiated coats with antimicrobial activity for three hours. A method of radiation of the coats with antimicrobial activity with applied suspension. A method of radiation of coats in advance with microbial activity for various time periods. The effectiveness have been tested on five microorganisms Escherichia coli, Staphylococus auereus, Pseudomonas aeruginosa, Bacilus subtilis and Candida albicans as the representative of eukaryotic organisms. Results At all methods G- microorganisms were more sensitive, which showed the sensitivity even without UV-VIS radiation. After longer time periods of contact G+ organisms were well...
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Gemcitabine in anti-rejection treatment in experimental liver transplantation
Mergental, Hynek ; Ryska, Miroslav (advisor) ; Bělina, František (referee) ; Třeška, Vladislav (referee)
The first part of thesis is focused on the technical aspects of experimental model of liver transplantation on rats. The second part describes the research project that tested a novel immunosuppressive drug gemcitabine compared to low dose of cyclosporine A on the acute liver rejection model. To use a cytostatic drug in a low dose with a minimal toxicity as an immunosuppressant would be attractive for clinical use. Particularly because liver transplantation for hepatocellular carcinoma represent a frequent indication nowadays and also due to risk of development of a new post transplant malignancies as an side effect of standard immunosuppressant. Our results showed lower nephrotoxicity compared to cyclosporine, however, did not confirm the previous optimistic reports in terms of rejection treatment as it only mildly decreased the rejection severity. Our data suggests that gemcitabine cannot be used as a main immunosuppressant alone.
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Teorie elektrodifuzních čidel třeni v mikrodisperzních kapalinách 8. Vliv zdánlivého skluzu na směrové charakteristiky
Wein, Ondřej
Insulated insertions between individual segments of direction-sensitive electrodiffusion friction probes attenuate the directionalsensitivity. Quantitative study of this effect by Wein and Wichterle (1989) for Newtonian liquids has been extended in a recent research report (Wein 2007) for the microdisperse liquids, displaying the Apparent Wall Slip, i.e. a non-linear velocity profile close to solid surfaces. In the present research report, this theory is used to the simulation calculations of directional characteristics for a class of 3-segment electrodiffusion friction probes with the insulating insertions. Rather realistic model of non-ideal 3-segment direction-specific probes is tested by comparison of the predictions with experimental data about an actual 3-segment probe in both homogeneous and microdisperse liquids.
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Econometric analysis of the economy in game World of Warcraft
Buchníčková, Michaela ; Kuchina, Elena (advisor) ; Formánek, Tomáš (referee)
This thesis analyses the impact of real exchange rate and the official exchange ratio of fiat currencies and in-game golds on the price level in the game World of Warcraft. The work also includes a brief summary of the mechanisms of the in-game economy. The analysis is based on cointegration test and Granger causality test. Individual estimations are model based on the VAR and VEC models theory. The conclusions of this study are made for specific randomly selected pairs of servers with different populations. These results are not easily generalized for the entire regions, but they offer insight into the possible factors affecting the price level in each virtual economy. The results show that the price level on the American server Aegwynn affects the exchange rates of fiat and game currencies as well as that game currency exchange rate in the European region is sensitive to changes in exchange rates of the euro and the yuan. All calculations in this work were implemented in Eviews 8 software.
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Interactions of selected antiepileptic drugs with MRP2 transporter
Garajová, Katarína ; Pávek, Petr (advisor) ; Červený, Lukáš (referee)
Interaction of the MRP2 transporter with selected anti-epileptic drugs Epilepsy is a common neurological disorder affecting approximately 1-2% of the population. In most of the patiens with epilepsy, seizures are well-controlled with currently available anti-epileptic drugs (AEDs). It is estimated that 30% of the patients fail to achieve seizure termination despite carefully optimized drug treatment. Most of these patients with refractory epilepsy are resistant to several AEDs with different mechanisms of action, which suggests that resistance in epilepsy is a multifactorial and drug-nonspecific phenomenon. Based on experimental and clinical studies, two major theories have been put forward to explain the development of pharmacoresistance in epilepsy. The target hypothesis holds that changes in properties of drug targets for AEDs may result into their reduced drug sensitivity. The transporter hypothesis contends that the over-expression of efflux multidrug-transporters in the brain leads to impaired access of AEDs to their targets. The largest and the most important family of multidrug-transporters expressed in the brain, is the ABC (ATP-binding cassette) transporter family. One of the transporters in this family, recently under study, is the multidrug resistance-associated protein 2 (MRP2). The MRP2...
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