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Safety of selected dietary supplements with regard to the content of food additives I.
Rohlíková, Martina ; Pokladníková, Jitka (advisor) ; Marešová, Helena (referee)
Safety of the selected food supplements in terms of the presence of additives Additives are commonly present not only in food, but also in food supplements. Safety of these substances remains a question. The aim of the theses is to evaluate the safety of the best selling supplements in the Czech Republic in the year 2011 from the viewpoint of additives and constituents. Given the scale of researched products, I focused on products strengthening the cardiovascular system containing omega 3 fatty acids , garlic, coenzyme Q 10 and lecithin. As a source of information about the content and the presence of additives, the data from the Ministry of Health and the Information System decision of the Chief Hygienist (IS RoHy) were used. The safety evaluation of additives was carried out on the basis of the available methodology for consumers. Information about adverse effects of additives and content substances were searched using information databases Martindale , Reprotox, AltMedDex, Drugdex, National Center for Complementary and Alternative Medicine (NCCAM), IPCS INCHEM, PubMed independent commission database JECFA Joint FAO / WHO Expert committee on Food additives. Descriptive statistics was used. Of the large number of products (97), 5 products were classified as safe and 92 as products harmful to...
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The quality of information on top selling dietary supplements on the internet in the Czech Republic
Baudischová, Lenka ; Pokladníková, Jitka (advisor) ; Marešová, Helena (referee)
THE QUALITY OF TOP SELLING DIETARY SUPPLEMENT INFORMATION ON THE INTERNET IN THE CZECH REPUBLIC Student: Lenka Baudischová Tutor: PharmDr. Jitka Pokladníková, Ph.D. Specialist: Ing. Katka Kvízová Dept. Of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech republic CONTEXT: Dietary supplements in recent years become part of the daily diet considerable part of the population of all European countries. According to the survey of 2015 internet purchases through OTC drugs and dietary supplements people buys more than two fifths of the internet population aged 15-59. The internet is often used by consumers as a source of information. If people buy a dietary supplement on the internet they get all information about a dietary supplement is from the web sites. OBJECTIVE: To assess quality of information presented on the Internet for the top selling dietary supplements from the clinical and regulatory point of view. METHODS: We searched the Internet using the 3 most commonly used search engines in the Czech Republic - Seznam, Google and Centrum starting July of 2015 till November of 2015. One-hundred top selling dietary supplements in the Czech Republic in 2014 were extracted from IMS Health database. Dietary supplement information was evaluated from the...
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Opinions, knowledge, perception of risks and compliance of patients using non-prescription drugs and dietary supplements II.
Hrabcová, Veronika ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
1 ABSTRACT Opinions, knowledge, perception of risks and compliance of patients using non- prescription drugs and dietary supplements II. Author: Veronika Hrabcová1 Tutor: Josef Malý1 1 Department of Social and Clinical Pharmacy, Charles University in Pague, Faculty of Pharmacy in Hradec Králové Introduction: In recent years, the self-medication in the Czech Republic has become an important part of health care of citizens who are actively involved in this process. OTC drugs and dietary supplements are an integral part of it. With their increasing supply in pharmacies, the cooperation of patients and professionals in pharmacies has become more important. Objectives: The aim of the thesis was to investigate the current opinions, attitudes, awareness and knowledge of the Czech patients who come into contact with OTC drugs. Methods: The data were collected from September 2013 to February 2014. The directed interview was conducted according to a prepared questionnaire.The data were collected in two surgeries of general practitioners for adults in the town of Uherské Hradiště. The obtained data were transferred to an electronic form using Google and subsequently processed using Microsoft Excel 2010. In this program, the data were evaluated by means of the frequency analysis and converted into tables and graphs,...
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The quality of information on top selling dietary supplements on the internet in the Czech Republic
Baudischová, Lenka ; Pokladníková, Jitka (advisor) ; Marešová, Helena (referee)
THE QUALITY OF TOP SELLING DIETARY SUPPLEMENT INFORMATION ON THE INTERNET IN THE CZECH REPUBLIC Student: Lenka Baudischová Tutor: PharmDr. Jitka Pokladníková, Ph.D. Specialist: Ing. Katka Kvízová Dept. Of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech republic CONTEXT: Dietary supplements in recent years become part of the daily diet considerable part of the population of all European countries. According to the survey of 2015 internet purchases through OTC drugs and dietary supplements people buys more than two fifths of the internet population aged 15-59. The internet is often used by consumers as a source of information. If people buy a dietary supplement on the internet they get all information about a dietary supplement is from the web sites. OBJECTIVE: To assess quality of information presented on the Internet for the top selling dietary supplements from the clinical and regulatory point of view. METHODS: We searched the Internet using the 3 most commonly used search engines in the Czech Republic - Seznam, Google and Centrum starting July of 2015 till November of 2015. One-hundred top selling dietary supplements in the Czech Republic in 2014 were extracted from IMS Health database. Dietary supplement information was evaluated from the...
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Safety of selected dietary supplements with regard to the content of food additives II.
Jajtnerová, Renáta ; Pokladníková, Jitka (advisor) ; Marešová, Helena (referee)
SAFETY OF THE SELECTED FOOD SUPPLEMENTS FROM VIEWPOINT OF THE PRESENCE ADDITIVES. Student: Renáta Jajtnerová Tutor: PharmDr. Jitka Pokladníková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague Introduction: Nowadays the additives are absolutely common part of our life and we encounter with them almost daily. We can find them not only in food but also in drugs or various food supplements. Their safety is often discuss and the opinions of individual experts are often different. Objective: The aim of this work is to evaluate the safety of food supplements in terms of the presence of food additives and their possible interactions with substances. The evaluation concern food supplements which occurred on the Czech market in 2011. Because the number of food supplements on our market is very high, I focused only on the supplements used for the support joints and for the treatment of osteoarthritis. Methodology: One of the pharmaceutical chains provided for us the list of best- selling products and the complete list of products we received from the Ministry of health. Than the composition of these supplements was sought on the Information system decision of the chief hygienist (Is RoHy) alternatively in the pharmacy or directly from the...
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Effectiveness and safety of selected dietary supplements
Smolíková, Kateřina ; Pokladníková, Jitka (advisor) ; Marešová, Helena (referee)
Effectiveness and safety of selected dietary supplements Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague Student: Kateřina Smolíková Tutor: PharmDr. Jitka Pokladníková, Ph.D. Introduction: The market for dietary supplements in recent years has seen a noticeable upswing and supplements become for some people part of their daily lives, which could mean potential risks. Objectives: To assess the effectiveness and risks of selected dietary supplements containing Vaccinium macrocarpon, Serenoa repens, Cimicifuga racemosa, Glycine max and Silybum marianum. At the same time, the aim of this work was to evaluate the safety of selected supplements from the point of view of content of additives, check undesirable effects of harmful additives and compare them with the identified undesirable effects of medicinal plants. Methods: Efficacy and safety were assessed on the basis of scientific studies. It has been rated 5 best-selling groups of food supplements in 2011. The list of 100 best-selling nutritional supplements in the Czech Republic were given to us by one pharmacy chain. From the most selling supplements was made a list of the most frequently occurring substances content which was sent to the Ministry of Health with a request to add...
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Comparison of composition and prices of OTC drugs and selected dietary supplements to reduce weight
Radová, Zuzana ; Bartošová, Olga (advisor) ; Štenglová Netíková, Irena (referee)
The bachelor thesis deals with the comparison of OTC drugs and dietary supplements to reduce weight. Orlistat and selected dietary supplements are compared in terms of their composition and price. The thesis is divided into two parts, theoretical and practical. The theoretical part of the thesis briefly describes the issue of overweight and obesity, especially in terms of pathogenesis, diagnosis, therapy and subsequent complications. The Orlistat chapter describes the pharmacokinetics, mechanism of effect, dosage and side effects of this sole registered OTC drug on the Czech market. The final chapter of the theoretical part describes the components in selected dietary supplements, which are rated in the theses. Because they are usually plant extracts as components, information about relevant plants is also included in the paper for its completeness. The practical part of the bachelor thesis is devoted to the comparison of two generic drugs for the treatment of overweight and obesity and selected dietary supplements to support weight reduction. Generic medicaments containing orlistat do not differ in their composition, there is different price in the order of tens CZK between generics. The price differs by up to 48,5 % between the pharmacy and the e-shop. Selected dietary supplements were compared...
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Preparation and characterization of foods and food supplements containing selected vitamins
Krupičková, Lucie ; Hoová, Julie (referee) ; Skoumalová, Petra (advisor)
The thesis is focused on preparation of protected form of vitamins for aplication to food and diatery supplemets. The theoretical part characterizes vitamins and describes their role in human organism. Furthermore, this chapter summarizes different methods of determination vitamins soluble in water and encapsulation of substances into liposomes. The last sections are focused on functional foods and dietary supplements. In experimental part, an optimalization of determination method was made. Selected vitamins were encapsulated into liposomes. Size, stability, encapsulation efficiency, long-term stability and long-term encapsulation efficiency after two weeks was determined there. All prepared liposomes were found to be stable enough. Furthermore, the vitamin solutions, liposomes and lyophilized particles were analyzed during the process of model digestion. The active forms of vitamins were degraded during the model digestion of vitamin solutions. Vitamins were gradually released from the liposomes and lyophilized particles into the digestive juice. The analysis of content declared by producer was executed for functional foods and dietary supplements. Finally, applications of protected form of vitamins into the food and dietary supplemets were created.
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UV-photochemical generation of volatile selenium compounds for ultratrace analysis by AAS
Rybínová, Marcela
This thesis deals with the study of UV-photochemical generation of volatile compounds (UV-PVG) in connection with atomic absorption spectrometry (AAS). Selenium (Se(IV)) was selected as a model analyte and many experiments were carried out to expand the current sum of knowledge of the topic. The study was commenced by assembling the UV-PVG apparatus in the continuous flow mode. The detection method used was AAS with externally heated quartz furnace atomizer. The focus of the first step of the study was on the construction of the volatile compounds generator (UV-photoreactor) with emphasis on the material used; tubes made of teflon or quartz of different diameters were tested. The construction of the apparatus was followed by optimization of the reaction conditions (the type and concentration of the photochemical agent and other agents, which increase the analytical signal; the carrier gas and the auxiliary hydrogen gas flow rate; the sample flow rate). Eventually, the analytical figures of merit of the selenium determination using the proposed method were found. The results showed that teflon reaction tubes are a good competitor to those made of quartz. The accuracy of the method has been successfully verified by analysis of certified reference material and its applicability has been further tested...
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Consumer preferences of adolescents in the field of sports nutrition
Kociánová, Karolína ; Voráček, Josef (advisor) ; Pecinová, Markéta (referee)
Title: Consumer preferences of adolescents in the field of sports nutrition Objectives: The objective of this work is to define factors that influence the behavior of adolescent consumers during the process of purchasing sports supplements. Methods: Data were obtained through quantitative research. Specifically, the method of electronic questioning was used for this work. Subsequently, a statistical evaluation of collected information was performed. Results: According to results of the research dietary supplements are regularly used by up to 75 % of adolescents aged 14-24 years (n = 237). The remaining participants simply do not recognize the need to buy these products or have never even thought about it, hence do not look for them at all. The most popular dietary supplements used by this age group are vitamins, minerals and protein supplements. Adolescents look for them mainly in order to boost their immunity, sports performance and to speed up the regeneration process. On the contrary, the research did not show a significant influence of doctors and other experts on dietary supplement consumption. Young people's consumer behavior is influenced mostly by their immediate surroundings, family, friends or by themselves. Results showed that adolescent consumers are mainly looking for quality products...
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