|
The Study of Transient Species and Precursors of Biomolecules using Spectroscopic Techniques
Ferus, Martin ; Civiš, Svatopluk (advisor) ; Šponerová, Judit E. (referee) ; Wild, Jan (referee)
The presented thesis is focused on a spectroscopic study of unstable radicals, ions and molecules in a positive column glow discharge and laser plasma. The research of these fragments is supplemented by a study of biomolecules formation from these species and influence of catalysts. Molecular dynamics of radicals, ions and unstable molecules has been studied using a time resolved Fourier transform infrared spectroscopy. Time resolved spectra of CH4, HCONH2, BrCN, CH3CN, CF3Br, (CF3)2CHBr positive column glow discharges have been measured and simulated using a kinetic model including molecular dynamics, collisions and chemical and radiation transfer processes. The model has been compared with our experimental results and time resolved spectra were described in details. Fit to a complex reaction mechanism has been used to estimate a rate constant of a HCN conversion to HNC by a collision with H radical. The study of precursors of biomolecules was focused on chemical consequences of a laser induced dielectric breakdown in formamide vapor and gaseous carbon monooxide with 18 O labeled water. Dissociation products have been detected using the Fourier transform absorption spectroscopy. The experimental results have been explained by a help of a chemical laser spark dynamics model. Additionally, our the...
|
|
Gold market analysis and the influence of commodities on portfolio diversification
Kováč, Jakub ; Musílek, Petr (advisor) ; Vorek, Marián (referee)
The objective of the Diploma Thesis entitled Gold market analysis and the influence of commodities on portfolio diversification is to provide an insight to commodities as an investment asset class. This goal is tackled by the first and the second chapter. The first chapter provides theoretical support for commodities as a distinct asset, whereas the second chapter is focused on investors opportunities to obtain economic exposure to commodity assets on current financial markets. When introducing the commodity products, main focus is set on the gold market. The second objective of the Diploma Thesis is to analyze the gold market and gold added value for the investors. The structure of both supply and demand for gold is analyzed. Demand and supply are identified as the main gold price drivers. The thesis confirms that the main added value of gold as an asset lies in its addition to a portfolio of capital assets. Gold significantly improves diversification of the portfolio, protects the portfolio from inflation as well as from the economic event risk. On the contrary, in comparison to capital assets gold is not an perspective stand alone investment. The last objective of the thesis is to analyze the diversification potential of commodity indexes within a portfolio context. The last chapter is devoted to this objective. The chapter introduces commodity indexes as an investible product and analyses the influence of a selected commodity index being added to a portfolio of capital assets on the efficient investment frontier. It is shown that not only is the commodity index not a good diversification tool but the investors would be better off by selling it short.
|
|
The anti-inflammatory effects of natural and synthetic triterpenoid coumpounds.
Spáčilová, Pavla ; Hajdúch, Marián (advisor) ; Džubák, Petr (referee)
The thesis is focused on in vitro testing of biological activities related to inflammation, such as inhibition of nitric oxide production and inhibition of reactive oxygen species formation in activated cells. 65 triterpenoid derivatives were tested in experimental section of the thesis for nitric oxide sythesis inhibition in B10R cells stimulated with lipopolysaccharide. 15 compounds showed terapeutic index value higher than 4, including three compounds which showed IC50 value lower than 10 μmol/l. 115 triterpenoid compounds were tested for inhibition of reactive oxygen species formation in RAW 264.7 cells stimulated with opsonized zymosan. Two compounds showed IC50 value lower than 10 μmol/l. None of 115 tested compounds showed NO·-scavenging activity. Four compounds showed a moderate O2-·-scavenging activity. Powered by TCPDF (www.tcpdf.org)
|
|
Aggregated Indicators in Ecological Economics
Syrovátka, Miroslav ; Brůha, Jan (advisor) ; Šauer, Petr (referee)
The aim of the thesis is to analyze three aggregated indicators and put them into the context of Ecological Economics. The second chapter points out that different sustainability perspectives imply distinct sustainability policies. Ecological Economics is outlined in contrast to Environmental Economics. Following three chapters analyze selected aggregated indicators. Aggregated indicators can provide quick insight into complex problems; however, their virtue depends to a large extent on the method of aggregation. Therefore, the interpretation of aggregated indicators should always be conditioned by their specific methodology. The Ecological Footprint is called technologically skeptical indicator of sustainability, applicable rather on a global than a national scale. Even on a lower scale the Ecological Footprint can illustrate demands of a given population for renewable natural resources. A major shortcoming of the Index of Sustainable Economic Welfare is the integration of welfare and sustainability into one indicator since it does not allow for a simple interpretation of its results. High correlation between the Human Development Index and the indicators of economic activity limits the usefulness of the former. Yet, it can serve as a basis for further evolution of the concept and measurement of human...
|
|
Mitochondrial cytochrome c oxidase: cyanide inhibition and role of assembly factor Surf1 defect
Nůsková, Hana ; Kalous, Martin (referee) ; Drahota, Zdeněk (advisor)
The activity of mitochondrial cytochrome c oxidase (COX) can be affected by either exogenous or endogenous factors. The most efficient and in the environment abundant compound that inhibits COX is cyanide. The very frequent cause of COX deficiency in humans is represented by a defect in the SURF1 gene. The mechanism of cyanide inhibitory effect on COX as well as the conditions for its recovery are not yet fully explained. Three parameters of COX function, namely the transport of electrons (oxygen consumption), the transport of protons (mitochondrial membrane potential, m) and the enzyme affinity to oxygen (p50 value), were studied with regard to the inhibition by KCN and its reversal by pyruvate. The function of COX was analysed in intact isolated rat liver mitochondria, both within the respiratory chain and as a sole enzyme, using succinate or an artificial electron donor ascorbate + TMPD as a substrate. 250 M KCN completely inhibited both electron- and proton-transporting function of COX, and this inhibition was reversible as proved with washing of mitochondria. The addition of 60 mM pyruvate induced the maximal recovery of both parameters to 60 - 80 % of original values. Using KCN in the low concentration range up to 5 M, a profound, 30-fold decrease of COX affinity to oxygen was observed....
|
|
Vývoj kurzu eura od vzniku společné měny po současnost
Břečková, Pavlína ; Taušer, Josef (advisor) ; Černá, Iveta (referee)
Bakalářská práce osvětluje nejdůležitější příčiny a události, které se podílely na determinaci směnného kurzu eura vůči dolaru, upozorňuje na složitost celého procesu do zavedení jednotné měny a historických událostí, které k jejímu vzniku vedly. Uvádí významné trendy ve vývoji kurzu, které se za dobu existence eura vyskytly a v poslední části se soustředí na vývoj kurzu eura vůči české koruně, tato cílová hodnota bude mít v době přechodu ČR na euro velký význam.
|
|
Problems of School Bufettes in the Elementary School in the District of Písek from the Assortment Offered in Terms of Suitability
PRŮCHOVÁ, Štěpánka
This thesis deals with the issue of school meals, especially with the assortment offered in school cafeterias. The theoretical part gives a definition of health and related terms such as determinants of health, prevention or health promotion, it describes the principles of healthy eating in children, including a food guide pyramid, ten commandments for healthy eating, daily food layout, drinking regime and individual nutritional food components. It also discusses the issue of school meals, which includes school canteens, school cafeterias and it also briefly describes the projects called Milk to Schools and Fruit to Schools, the purpose of which is to increase the consumption of foodstuffs important for children's diets. In the practical part two research methods were used. In the qualitative research, operators of school cafeterias were interviewed in order to survey the offered assortment. Answers to the questions were organized into a classification scale, and for each cafeteria, based on the calculated evaluation index, the average suitability value of the offered assortment was stated in individual surveyed facilities. The other, quantitative research, was conducted through interviews using questionnaires with 14 questions, which were distributed among pupils of the second grade of primary schools to determine children's eating habits in the surveyed school. The results have shown that the offer of food in school cafeterias is not optimal for healthy nutrition for children. In the offered assortment, foodstuffs rich in simple sugars and salt content prevail, which contributes to the rise of civilization diseases. The results of the qualitative research have also proved that with the increasing age children´s eating habits worsen and also the frequency of shopping in the school cafeteria rises.
|
|
Investiční rozhodování v IT a ROI jako prostředek měření přínosů ITSM pro business
Zakharenkava, Sviatlana ; Voříšek, Jiří (advisor) ; Tolar, Jan (referee)
The Diploma Thesis is dealing with questions of investment decision-making in the area of IT and can be a complete guidance on the basic concepts of decision-making on the investment projects, methods of financial evaluation of such projects and the ways of its application in the sphere of IT. It is mainly aimed on the projects dealing with internal processes in IT organizations and optimalization of its management ? IT Service Management (ITSM). The paper deals with existing methodologies and standards applicable to IT Service Management and closely works with the latest library of best practices ITIL V3. The introduction gets the reader into the basics of the IT management, introduces the existent market standards and creates a liaison between the IT and business in questions of investments. The second part pays attention to the principles of ITSM and describes the benefits that can process optimalization bring to the company. The third chapter opens up the IT investment topic and introduces various methodological concepts and models used not only in the classical financial theory, but in the modern management practice as well. It offers a basic overview on the methods of investment project evaluation, e.g. Net Present Value (NPV), The Payback Period Method, The Internal Rate of Return (IRR), The Profitability Index, and the most popular one ? Return on Investment (ROI). The following chapter applies the measure of Return on Investment (ROI) to the projects of ITSM implementation according to ITIL. It shows the basic principles of the method usage, describes its main components and introduces the way of identification and evaluation of the benefits, which those projects bring to the business. Gained knowledge is based on the real practical examples ? several worked-out business cases created for the customers of the Hewlett-Packard Company. The last part of this chapter shortly describes several software tools for building the similar business cases and their own methodology. The last chapter in devoted to the situation on the local and world market and addresses the practical application of the methods of IT projects evaluation in the companies. The conclusion then summarizes important parts and key elements of the paper.
|
|
Financial analysis of LDM, Ltd.
Čečotka, Miroslav ; Boukal, Petr (advisor) ; Eisler, Jan (referee)
Dissertation is divided into two major parts -- the former is dedicated to theoretic approches to financial analysis, the latter to application of previously gained knowledge in a company. The introduction of work is dedicated to the purpose, usage and approaches to financial analysis with respect to various users of the analysis output. Moreover the document in a very detailed way deals with sources of data for financial analysis processing including weak points and their reflection in ability of calculated indicators of the financial analysis (FA) to give evidence. The most attention is of cource paid to individual steps in thorough financial analysis -- ie. vertical and horizontal analysis of statements and calculations of proportionate indicators including indicator examples from separate spheres of the analysis. Systems of indicators -- parallel but mainly pyramidal, concretely Du-pont's model is used. Dissertation thereinafter is devoted to another indicators that are useful for appreciation of the financial company health, concretely Altman's model, Kralicek's quicktest, Index IN and economic value added (EVA indicator). Comparision with branch of activity that is the company work in is a part of dissertation too. In the second part of the work, a specific company is being analysed -- in successive steps meant in the previous part. After statement analysis and calculations of proportionate indicators, I evaluate to what degree the company is successful. Simultaneously the results can indicate that outputs from the well elaborated financial analysis are of a very useful source of information for company management.
|
|
Brand management
Puškárová, Jana ; Kašparová, Eva (advisor) ; Surynek, Alois (referee)
This Bachelor´s Thesis deals with brand building and strategic brand management. The aim of this thesis is to determine on the basis in depth interviews and subsequent analysis to determine what kind of activities Samsung uses to develop and build its brand and what their impact. In the theoretical part, there are presented definitions related to the concept of a brand as an element of brand identity and brand image, positioning of a brand, brand equity and its measurement. The following section describes the process of building a brand and its strategic management, which also includes the specifics of internal branding and position of brand manager. The practical part contains an analysis of the Samsung brand building, its brief history, vision of the company and current strategy. Based on in depth interviews will be analysed in detail each activity aimed at building a Samsung brand. In this thesis is also included a case study, which examines the introduction and later success of Facebook page Samsung Česko a Slovensko. The last part consists of SWOT analysis, which provides a detailed view of strong and weak sides of the Samsung brand, also its opportunities and threats.
|
guest ::
