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The emergency response organization of NPP Temelín operator
KOŠŤÁL, Jaroslav
This work deals with Organization of Emergency Response in NPP. According assignment this work summarizes its legal preconditions and consequently gives description of its practical realization. The necessary terminology is gathered and the basic overview of OER functioning is given. An attention is paid to staffing, structure and number of workplaces, the used documentation and also to the system of its readiness and functionality verification. The intent is to define the essential aspects of nuclear safety and to describe system of emergency planning and response in condition of real nuclear facility. In the second part of work a comparison of Stress Tests of EDU and ETE NPPs in the reason to evaluate how the goals of Emergency Response are met. The comparison of Stress Tests results is done in shape of tables. My interpretation of the established facts is: 1.The probability of earthquake exceeding the design resistant of structures, technological systems and structures is practically insignificant. The results are for both locations virtually identical. The project robustness of ETE NPP to earthquakes is slightly higher than EDU. 2.The flooding robustness of both our NPP sites is high. Both NPPs are due to its location very resistant to rain water flooding. To ensure a high level of resistance to rain water flooding requires regular maintenance of drainage systems. 3.EDU and ETE NPPs are resistant to earthquakes and in this way they are resistant to the extreme weather condition especially to the gusty wind too. 4.Secured power internal consumption supply systems on EDU and ETE NPPs are projected according to analogical basics and are enough robust to failure from common cause. To secure safe down-cooling of reactor unit the only one independent power supply system is sufficient. In project of ETE NPP there is in comparison with EDU NPP the next system of common independent power consumption supply. It is primarily intended to prevent damages in technology of secondary circle. Two DGs strongly improve the resistance of unit to SBO accident. 5.Heat removal from separate technological systems is on both power stations realized by using of analogical cooling system. Constructional differences in projects of our power stations are given by different time of their project works. There is a possibility that cooling systems of EDU NPP will be improved. 6.System of severe accident management is organized in the similar way at both facilities. The staff of Accident Board and Technical Support Centre is analogical. Recently the staff of TSC was reinforced to improve its ability to cope the multiply accident on several units. The documentation for solving of abnormal states, accidents and severe accidents has got the same basic structure. Procedures and guidelines are continually improved. Attention is paid to verification and validation of these procedures. 7.On the basis of performed Stress Tests there is a high possibility of gradual realization of partial administrative, personal and technological improvements that will be done in reason to improve Nuclear Safety and Organization of Emergency Response. The specific measures are summarized in the National Action Plan. An absolute elimination of an accident is impossible, but the probability of an accident with fuel degradation must be as low as it is reasonably possible to achieve. The NPP must be able to diminish the impacts of such event to the generally acceptable low. The ability to manage such events is the major goal of Emergency Response that should be taken as a sophisticated interdisciplinary system.
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Synthesis of colloidal gold nanorods for biomedical applications
Valkovičová, Jiřina ; Bernard, Vladan (referee) ; Drbohlavová, Jana (advisor)
Diplomová práce se zabývá výrobou a využitím zlatých koloidních nanotyčinek v biomedicínských aplikacích. Konkrétně se zaměřuje na tři základní funkce nanočástic v analýze - transportní, separační a především zobrazovací. V části o využití nanočástic pro zobrazování je hlavní zájem věnován zejména povrchové plazmonové rezonanci zlatých nantyčinek. Dále je práce zaměřena na využití nanotyčinek pro termální terapii. Následující část je věnována vhodným modifikacím povrchu, hlavně za účelem zmírnění toxicity částic. Závěrem teoretické části jsou způsoby přípravy zlatých koloidních nanotyčinek a techniky jejich následné analýzy. V navazující experimetální části jsou uvedeny postupy, podmínky a výsledky provedených pokusů.
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Surveillance of bacterial strains producing broad-spectrum beta-lactamase.
VLASOVÁ, Martina
In the first part of my thesis I focus on mapping problems associated with antibiotic therapy and subsequent development of antibiotic resistance. Tracking resistance is based primarily on data collection and evaluation of the results set sensitivity from around the world. Antibiotic resistance is a natural phenomenon that can be observed in the evolution of microbes as one of the mechanisms of adaptation to new conditions in the environment. For this work I have chosen the following research questions. Do the incidence of ESBL strains in the České Budějovice Hospital a.s. increase over time? Are these values comparable to those achieved in another region, namely in Moravian hospitals the University Hospital of Olomouc, Ostrava University Hospital and Regional University Hospital of T. Bata in Zlin? The data collection I made in collaboration with the laboratory technicians and doctors at Hospital?s Bacteriology Laboratory in České Budějovice. Bacteries tested for the detection of ESBL production originated from biological materials, witch came from patients of hospital in České Budějovice. The first objective was to compare the results achieved in the České Budějovice Hospital in the period of 2007 to 2012. If we look at the total number of ESBL strains that have been isolated since 2007, values have upward trend. While in 2007 there were only 64 strains a year later, the number more than doubled. In 2010, the value soared to 281 tribes and in the year 2012, the number was 321 tribes. The incidence of ESBL strains in 2007 increased about five times. In the long term we can say the numbers have increasing tendency and the range of each species in the production of ESBL has significantly changed. In 2007, it was K. pneumoniae strains that dominated the statistics, but over time the strains of E. coli came forefront. Values of 2012 suggest that the presence of ESBL strains of K. pneumoniae is again almost equal to the number of E. coli strains. The second objective was to compare the results of the 2012 with study of the Prevalence of ESBL-positive Enterobacteriaceae in large Moravian hospitals. In the general overview of ESBL producers values in Hospital České Budějovice (5.23%) are comparable to those in Ostrava (4.9%) and in Zlín (4.3%). Number of strains in the Hospital in Olomouc (11.8%) is about twice as high as the numbers in České Budějovice. In this comparison the České Budějovice Hospital is one of the hospitals with a lower incidence of ESBL producers. The České Budějovice Hospital is below the national average, which originate from an elaborate system of care for patients with colonization or infection with ESBL strains, and from therapy control system using antibiotic center. These results may serve to the Hospital in České Budějovice for statistical purposes, and also for proposals for improving patient care. In the discussion, I pointed out the danger of the spread of resistant strains of bacteria in the community and also the associated risks that mentioned bacteria mean for patients injured in mass accidents or disasters. In these cases, number of infections including ESBL producers can penetrate through open wounds into the affected body. Unlike conventional sensitive bacteria those strains are resistant to commonly used antibiotics and thereby endanger the lives of people affected by the accident.
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Road-traffic accident rate
Haluska, Roman ; Mandák, Ladislav (referee) ; Kaplan, Zdeněk (advisor)
This thesis deals with description of the former state and reviews reconstructions dangerous sections of roads where there were frequent accidents with large material damage and heavy or fatal injuries. This thesis describes and proposed further preventive action, particularly for pedestrians and cyclists, which leads to a reduction in traffic accidents. At the conclusion of this work is also recommended for drivers to attend a course on the polygon circuit to increase driving experience of a different kind of road surface and for different weather conditions (dry surface, rain, ice, snow).
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Development of tool for passive immunization of cystic fibrosis patients
Pacholíková, Lenka ; Hodek, Petr (advisor) ; Švédová, Martina (referee)
Cystic Fibrosis (CF) is one of the most common heriditary diseases. This congenital condition, caused by CFTR gene mutation, affects gastrointestinal and respiratory system especially. The affection of respiratory system is considered the most serious life-threatening symptom. Pacients suffer from reccurent infections proceeding to the development of chronic inflammation and progressive pulmonary tissue destruction. A typical specific microoganism colonizating pulmonary tissue of thouse suffering from CF is recognised as Pseudomonas aeruginosa. Pulmonary infections caused by this microorganism are the most often cause of death in patients suffering from CF. Antiobiotics are the first-line therapy of this condition currently. Nevertheless, the need to find alternatives occurs due to antibiotics resistance development. Passive immunization by specific hen-egg-yolk antibodies against P. aeruginosa is a possible alternative. An observation of IgY influence on a bacterial adhesion to pulmonary epithelial cells required an appropriate model. In this context an appropriate adhesion testing method based on P. aeruginosa and pulmonary epithelial cells visualisation was searched. At first bacterial cells labelling was tested by CellTracker, resazurin, FITC and consequently PKH 26. P. aeruginosa fluorescent...
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Use of vibration in sports and health care
Koutná, Martina ; Malá, Jitka (advisor) ; Pavlů, Dagmar (referee)
Title: The Use of Vibration in Sports and Health Care Objectives: The aim of this study is to confirm or refute established hypotheses. Hypotheses: 1. The use of vibration loading improves muscle strength. 2. The use of vibration loading improves bone mineral density. 3. The use of vibration loading can influence balance. Methods: This diploma thesis is elaborated as search form. It is based on exploration of available literary sources, clinical trials accessible through electronic databases of medical and sports, and library catalogs. The resources from sport, physiology, biomechanics, and various medical disciplines (osteology, physiotherapy, kinesiology) were used also. Results: Due to retrieval process of whole body vibration training it was found out that this method can improve muscle strength, bone mineral density, balance and mobility. The effect depends on chosen parameters of whole-body vibrations. Under certain conditions whole-body vibration training could represent an alternative or a supplement to conventional training in order to increase muscle strength and bone mineral density or improve balance and mobility of elderly. The selection of right vibration parameters could support ordinary physical therapy of some neurological disorders. Keywords: vibration, whole-body vibration...
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Nursing process in seniors suffering from pain
HÁKOVÁ, Eva
Abstract Ageing is an irreversible and nonrecurring biological process. Old age is the final stage of life. It is characterized by involutional and mental changes. Ageing has a significent impact on the social status of a person. The typical attribute of old age is polymorbidity. The aged often suffer from chronic ailment that go together with pains. Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Nociception is the physiological event that is accompanied by pain. Nonpharmaceutical therapies affect human mind and thus help to ease pain. These techniques enhance the quality of life and make life more comfortable. The aim of my thesis was to make a survey of nonpharmaceutical inhibition of perception of pain at the nursing process in seniors staying at retirement homes or nursing homes. Using a method of questionnaires as a quantitative research, I focused on the question of using alternative, nonpharmaceutical method of pain management after the previous assessment of a patient´s condition. To different medical care facilities, 120 questionnaires were handed out. The 85 questionnaires that were filled in correctly were used for evaluation . The respondents were selected at random {--} 41 nurses from homes for seniors and 44 nurses working in long-term care facilities. From the Hvizdal retirement home I received only 13 questionnares I could assess and from the Maj retirement home only 16 nurses handed in the questionnaires filled in correctly. I was given 12 correctly filled questionnaires from the retirement home in Jicin and 28 from the Gerontcentre in Hostinne. The total number of 85 correctly filled questionnaires is completed by those 16 from nurses working in the long-term care facility in Lomnice nad Popelkou. The objective of my thesis has been achieved. The hypothesis H I {--} nurses working with seniors in medical care facilites use nonpharmaceutical therapies after the previous assessment of a patient´s condition {--} was confirmed. The hypothesis H II {--} nurses use nonphamaceutical therapies without the previous assessment of a patient´s condition {--}was not confirmed.
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Suppositories in current therapy I
Kočová, Alena ; Musilová, Marie (advisor) ; Doležal, Pavel (referee)
Suppositories are a conventional dosage form. Although their research is not being developed much further, there are still some changes to be found. Some new adjuvants have been used, the old active substances have been deleted and replaced by new ones. The last survey of rectal preparations was created in 1998. This paper provides an overview of proprietary rectal and vaginal suppositories, which were available on the market in 2010. There is a list of such products, medicinal substances used and their percentage. There are adjuvants and packaging materials, too. We found values of the melting temperature of those suppositories, which were stored under different conditions. These values were correlated to times of deformation of the preparations. On the basis of the evaluated data we recommend monitoring of changes in the melting temperature and the time of deformation of the products DICLOREUM 100 and KETONAL.
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Stress-strain analysis of arterial aneurysms
Tesařová, Petra ; Skácel, Pavel (referee) ; Burša, Jiří (advisor)
The diploma thesis is focused on the creation of the aneurysm finite element model and the making of the aneurysm wall stess-strain analysis using ANSYS software. The model of abdominal aortic aneurysm geometry starts from the CT scan of the particular patient. In the thesis there are compared two chosen constitutive models, each of them appears from different mechanical tests done on human arterial fibre samples. Furthermore, a limiting condition for aneurysm wall structure damage is expressed. On the basis of the results of stress calculation in the aneurysm wall and the limiting condition, the safety coefficient and rupture factors risk are worked out.
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