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Metastable beta titanium alloys for biomedical use
Preisler, Dalibor ; Stráský, Josef (advisor) ; Janeček, Miloš (referee)
In this work the effect of die-forging and annealing on the mechanical properties and microstructure of biocompatible metastable alloy Ti-35.3Nb-7.3Zr -5.7Ta-0.7O (wt. %) was studied. Light and scanning electron microscopy, microhardness tests and tensile tests were used to study all prepared conditions. As-cast and as-annealed conditions showed chemical inhomogeneities exhibited as dendritic structure, grains with size of hundreds of micrometers and numerous pores having size of units of micrometers. Precipitation of alpha phase particles was negligible in as-annelaed conditions and only grain boundary alpha paticles formed. Die-forged condition showed grain sizes in the wide range of hundreds of micrometers down to micrometers. Both as-annealed and die-forged conditions showed increased microhardness compared to as-cast condition, but there were no significant differences between different annealing conditions. Yield stress of 870 MPa was found for as-cast condition while as-forged condition exhibited even higher yield stress of 1120 MPa. In both conditions, good room-temperature ductility was demonstrated. Due to its high strength, this alloy is perspective for manufacturing of joint implants.
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Finding Balance with Adderall: Responsibilization Discourses in Online Fora
Benešovská, Barbora ; Čada, Karel (advisor) ; Hájek, Martin (referee)
This thesis explores the discourses that surround psychopharmacological stimulant use in the online forum on reddit.com. The focus is on the negotiations of variable effects that people ascribe to the medication use. In the collective search for explanations and remedies, individuals become responsible for different aspects of their life in order to reach a balanced state. This state is constantly at flux and dependent on many variables, that are to be taken under control. Users thus have to monitor themselves and acquire self-knowledge, that is a based on listening to their embodied experience, and they have to adjust their bodies and daily routines. The idea of finding the right balance, that is informed by the embodied experiences, is closely connected to the ancient humoralist forms of governmentality. However, unlike in ancient humoralism, where balance necessarily meant adapting to the environment, biotechnologies have expanded the horizon of posssible modulations of bodies and selves, that may be achieved by the individuals themselves.
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Legal Status of Unborn Child and Need of Its Protection in the Light of Biomedical Development
Urminská, Lucie ; Frinta, Ondřej (referee)
Thesis deals with the legal status of an unborn child within current Czech legislation. In the introductory part, the author attempts to clarify the way in which today's society perceives the value of human life before birth. The author looks at the moment of when life begins from different points of view and also observes artificial interferences with the prenatal development of the child, which are the phenomenon accompanying the development in human knowledge and the use of biomedical technologies. In that context, the author analyses position of the European Court of Human Rights to the issue of the beginning of human life through its decisions. The core theme of the thesis is the analysis of the legal status of unborn child in the Czech Republic and of the protection granted by international and national legislation to the unborn child. The author particularly focuses on private law by examining the relevant provisions of the Act No. 89/2012 Coll., the Civil Code, as amended, which determine the legal status of the nasciturus. Among the crucial institutes to which attention is paid belongs legal personality, legal capacity, but also, for example, legal representation of the nasciturus. Further, the rights and the duties of the nasciturus are discussed, giving more detailed attention to the...
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Legal Status of Unborn Child and Need of Its Protection in the Light of Biomedical Development
Urminská, Lucie ; Frinta, Ondřej (referee)
Thesis deals with the legal status of an unborn child within current Czech legislation. In the introductory part, the author attempts to clarify the way in which today's society perceives the value of human life before birth. The author looks at the moment of when life begins from different points of view and also observes artificial interferences with the prenatal development of the child, which are the phenomenon accompanying the development in human knowledge and the use of biomedical technologies. In that context, the author analyses position of the European Court of Human Rights to the issue of the beginning of human life through its decisions. The core theme of the thesis is the analysis of the legal status of unborn child in the Czech Republic and of the protection granted by international and national legislation to the unborn child. The author particularly focuses on private law by examining the relevant provisions of the Act No. 89/2012 Coll., the Civil Code, as amended, which determine the legal status of the nasciturus. Among the crucial institutes to which attention is paid belongs legal personality, legal capacity, but also, for example, legal representation of the nasciturus. Further, the rights and the duties of the nasciturus are discussed, giving more detailed attention to the...
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Legal Status of Unborn Child and Need of Its Protection in the Light of Biomedical Development
Urminská, Lucie ; Salač, Josef (advisor) ; Šustek, Petr (referee)
Thesis deals with the legal status of an unborn child within current Czech legislation. In the introductory part, the author attempts to clarify the way in which today's society perceives the value of human life before birth. The author looks at the moment of when life begins from different points of view and also observes artificial interferences with the prenatal development of the child, which are the phenomenon accompanying the development in human knowledge and the use of biomedical technologies. In that context, the author analyses position of the European Court of Human Rights to the issue of the beginning of human life through its decisions. The core theme of the thesis is the analysis of the legal status of unborn child in the Czech Republic and of the protection granted by international and national legislation to the unborn child. The author particularly focuses on private law by examining the relevant provisions of the Act No. 89/2012 Coll., the Civil Code, as amended, which determine the legal status of the nasciturus. Among the crucial institutes to which attention is paid belongs legal personality, legal capacity, but also, for example, legal representation of the nasciturus. Further, the rights and the duties of the nasciturus are discussed, giving more detailed attention to the...
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Detection, Localization and Determination of Chronic Wounds
Gulán, Filip ; Dvořák, Michal (referee) ; Drahanský, Martin (advisor)
The aim of this diploma thesis is to design and implement a multiplatform application for detection, localization and determination of the extent of chronic wounds. The application is intended to assist nurses, doctors and healthcare assistants to monitor and evaluate chronic wounds in the course of treatment. The application is based on the Typescript programming language, on the Ionic hybrid application framework and on the Electron desktop application framework. Chronic wound assessment runs on the server-side where the Python programming language is used. The Flask application framework is used for the RESTful application interface and the OpenCV library is used for image processing.
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Epitaxial growth and characterization of metamagnetic nanoparticles for biomedical applications
Motyčková, Lucie ; Gröger,, Roman (referee) ; Arregi Uribeetxebarria, Jon Ander (advisor)
Magnetické nanočástice představují perspektivní prostředek pro široké množství biomedicínských aplikací v neustále se rozvíjejících oblastech diagnostiky a léčebné terapie. Využití magnetických nanočástic z metamagnetických materiálů by mohlo poskytnout výrazný přínos například z hlediska zlepšení ovladatelnosti biologických subjektů uvnitř lidského těla. Tato práce se zabývá růstovými mechanismy a magnetickými vlastnostmi nanočástic ze slitiny železa s rhodiem (FeRh) ukotvených na substrátu MgO. Slitina FeRh byla vybrána pro její specifickou fázovou přeměnu z antiferomagnetické do feromagnetické fáze nastávající v blízkosti pokojové teploty, což umožňuje ovládání magnetických vlastností nanočástic v teplotním rozsahu blízkém lidskému tělu. Prezentované nanostruktury jsou vyráběny magnetronovým naprašováním využívajícím přístup samouspořádání “bottom–up”. Morfologie a magnetické chování připravených nanostruktur jsou vyšetřovány pomocí mikroskopie atomových a magnetických sil, které umožňují získat prostorové rozložení feromagnetických a antiferomagnetických domén v jednotlivých nanoostrůvcích.
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Magnesium alloys designed for medical applications
Zemková, Mária ; Minárik, Peter (advisor) ; Vojtěch, Dalibor (referee)
Title: Magnesium alloys designed for medical applications Author: Mária Zemková Abstract: This Master thesis is focused on the influence of hot extrusion and equal channel angular pressing (ECAP) on the microstructure, mechanical and corrosion properties of magnesium alloys. Investigated materials include three magnesium alloys with the addition of neodymium and/or yttrium elements - N3, W3 and WN43, as a potential material for medical applications. Moreover, the influence of alloying elements in solid solution state was studied. Microstructure development was characterized by scanning electron microscopy together with transmission electron microscopy and X-ray diffraction. Mechanical properties was studied by compression deformation tests in two perpendicular directions and by microhardness tests. The linear polarization method was used to study corrosion resistance. The processing though ECAP resulted in grain refinement in all three alloys. Ultra-fine grained microstructure was achieved in W3 and WN43 alloy. The high degree of recrystallization during ECAP caused the formation of high-angle grain boundaries in all three alloys. Weak texture evolution was maintained during both processings. A different initial fraction of intermetallic phases before extrusion led to significant changes of microstructure...
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Metastable beta titanium alloys for biomedical use
Preisler, Dalibor ; Stráský, Josef (advisor) ; Janeček, Miloš (referee)
In this work the effect of die-forging and annealing on the mechanical properties and microstructure of biocompatible metastable alloy Ti-35.3Nb-7.3Zr -5.7Ta-0.7O (wt. %) was studied. Light and scanning electron microscopy, microhardness tests and tensile tests were used to study all prepared conditions. As-cast and as-annealed conditions showed chemical inhomogeneities exhibited as dendritic structure, grains with size of hundreds of micrometers and numerous pores having size of units of micrometers. Precipitation of alpha phase particles was negligible in as-annelaed conditions and only grain boundary alpha paticles formed. Die-forged condition showed grain sizes in the wide range of hundreds of micrometers down to micrometers. Both as-annealed and die-forged conditions showed increased microhardness compared to as-cast condition, but there were no significant differences between different annealing conditions. Yield stress of 870 MPa was found for as-cast condition while as-forged condition exhibited even higher yield stress of 1120 MPa. In both conditions, good room-temperature ductility was demonstrated. Due to its high strength, this alloy is perspective for manufacturing of joint implants.
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