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Effect of pharmacotherapy in idiopathic thrombocytopenic purpura (ITP)
BRYCHTA, Jakub
This study focuses on the monitoring of platelet count dynamics during pharmacotherapy in patients with idiopathic thrombocytopenic purpura (ITP) and the comparison of the efficacy of different treatment strategies. To achieve this goal, venous blood samples from patients diagnosed with ITP were analyzed and stored in the anticoagulant K3EDTA. Subsequently, platelet count (PLT) and percentage of immature reticulated platelets (IPF) were quantified using the XN series hematology analyzer from Sysmex. All results were recorded and evaluated in excel software. Subsequently, 3 tables were created from the results and patients were categorized according to the type of treatment. Finally, 5 case reports of patients with ITP were selected. The results of this study provide insights into the effects of pharmacotherapy in patients with ITP and provide insights into the effectiveness of different treatment options. These findings may provide useful information for envisioning the optimal treatment regimen for individual patients with ITP. A better understanding of aspects of this disease may lead to an improved quality of life for patients with ITP. The individual response of patients to treatment is crucial, with the choice of treatment depending on the severity of symptoms and side effects. Mean platelet values differed between the groups of patients without treatment, with first-line and second-line treatment. I also noted that proper treatment can lead to an increase in platelet count. Individual approach to patients and regular monitoring of response to treatment is important. New methods of pharmacotherapy for ITP offer a more targeted treatment effect.
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Automatic diagnosis of the 12-lead ECG using deep learning
Blaude, Ondřej ; Smital, Lukáš (referee) ; Provazník, Valentine (advisor)
The aim of this diploma thesis is to investigate the problematics of automatic ECG diagnostics, namely on twelve-lead recordings. In the first chapter the heart and its electrical activity measurement is described shortly. In addition to that, the abnormalities which are going to be classified in this thesis are also briefly described. In the second chapter, it is described how the ECG was diagnosed earlier, by classical methods that preceded deep learning. Some of the shortcomings that the classical methods have compared to deep learning are also described here. The third part already pays attention to deep learning itself, and its contribution and advantages compared to classical methods. Convolutional neural networks and their individual blocks are also described here, later attention is paid to selected architectures that were used in some studies. The fourth chapter already focuses on the practical part, in which the data used from the PhysioNet database, the proposed algorithm and its implementation are described in more detail. In the fifth chapter the results are discussed and compared to the corresponding publications.
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Validization of diagnostic methods in PTSD
Vágnerová, Anna ; Preiss, Marek (advisor) ; Heider, David (referee)
With this work, I became involved in an ongoing project of tool validation for measuring psychological trauma within the activities of the National Institute of Mental Health - Validation of tools for measuring psychological trauma. The aim of this thesis was to collect data from a clinical population with posttraumatic stress disorder (PTSD) and compare it with the results of diagnostic methods in the general population (N=303). The research clinical sample consisted of 31 respondents who, based on diagnostic criteria for PTSD diagnosis according to DSM-5, were divided into two research groups - with a probable PTSD diagnosis (N=17) and without a probable PTSD diagnosis (N=14). In this work, the results of three research groups were compared using the PTSD Checklist 5 method, which assesses the level of traumatization, and the Life Events Checklist-5 method, which examines the frequency of experienced traumatic events. At the same time, measurement of depressive and anxious symptoms of all participants was conducted to assess convergent validity. The results of statistical analysis showed that the PCL-5 method proved to be valid. The group with a probable PTSD diagnosis achieved statistically significantly higher values than the general population group, even in the results of methods measuring...
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Application of Electromagnetic and Acoustic Emission for the Diagnostics of Advanced Composite Materials
Trčka, Tomáš ; Chobola, Zdeněk (referee) ; Lokajíček,, Tomáš (referee) ; Koktavý, Pavel (advisor)
The subject of this dissertation is a theoretical and experimental study of electromagnetic and acoustic emission generated in the course of crack formation in solid dielectric materials. Theoretical part of this work is focused on the electromagnetic emission method, because it is related to a number of unsolved problems in the field of generated emission signals measurement, as well as in the field of the correct interpretation of obtained experimental data. Consequently, issues of emission signals detection by capacitance sensors and the transformation of crack primary parameters on the measured variables within the proposed transfer system have been dealt with. The results in this area were an extension of application range of the electromagnetic emission method on composite materials (especially on fiber reinforced polymer composites), identification and evaluation of the most significant emission sources in investigated composites and developing a methodology for evaluating of the crack primary parameters based on the measured emission signals waveforms in time and frequency domain. The experimental part of this dissertation was focused on a complex methodology for emission signals (including data from additional sensors) continual recording, processing and evaluation and for monitoring the response of stressed material to an applied mechanical load in real-time. Partial results from different research areas were also implemented into this methodology. This included the detection of emission signals, design and implementation of the appropriate measuring apparatus, analysis of measured signals in the time and frequency domain and advanced methods for processing and evaluation of measured data.
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Condition monitoring of small ball bearings
Šváb, Štěpán ; Pikula, Stanislav (referee) ; Havránek, Zdeněk (advisor)
The aim of this thesis was to build equipment for testing bearing condition analysis during its life. The theory of bearing parameter and diagnostics methodology for their analysis are discussed. Hardware used for device design and data collection. Finally, the course of measurement and software evaluating the end of the test are discussed.
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Survey, Diagnostics and Design of Reconstruction
Novotný, David ; Heřmánková, Věra (referee) ; Anton, Ondřej (advisor)
The subject of this thesis is the diagnostic investigation of block A in the object at Rumiště 8, Brno. The work includes theoretical knowledge of technical surveys and diagnostic methods and their evaluation to identify the essential characteristics of masonry and timber structures. In the practical part is the diagnostic investigation processed. Part of the diagnostic investigation is the determination of material characteristics of the structure. At the end of the thesis is an assessment of the structure.
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Survey and Diagnostics of Building Construction
Řezáč, David ; Heřmánková, Věra (referee) ; Anton, Ondřej (advisor)
The diploma thesis deals with the construction and technical survey of a reinforced concrete structure. The theoretical part describes the tested properties of concrete and the methodology of their tests used in the practical part. The practical part is devoted to the diagnosis of the existing structure, which was determined the strength of concrete using core holes, concrete adhesion by tear tests, and reinforcement of reinforced concrete elements of the structure determined by ground-penetrating radar, electromagnetic indicators and additional chopped probes.
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Winding diagnostics using surge test
Vojtěch, Pavel ; Šlezingr, Jan (referee) ; Drápela, Jiří (advisor)
Master‘s Thesis deal with analysis given to diagnostic method plus her applicability to failure detection electrical machine plus apparatus in different phases their live. A further realization physical model with subtransient generátor PSG204A 4kV, for teach – in disorder on single – layer air coil plus stator winding induction motor inclusive evaluation results test.
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Survey and Diagnostics of Building Construction
Vítková, Barbora ; Heřmánková, Věra (referee) ; Anton, Ondřej (advisor)
The subject of this diploma thesis is the diagnostic survey of the masonry walls and the connecting bridge in the East Moat of Špilberk Castle. The thesis contains theoretical information about survey and diagnostics of building construction and then evaluation of diagnostic methods used for estimation of essential characteristics of masonry structures. In the practical part the diagnostic investigation of Špilberk Castle walls is processed. That includes determination of material characteristics of the studied structure. In the conclusion there is a suggestion of how to eliminate the structural defects found during the survey.
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