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The size and surface charge of oligoester nanoparticles in the course of their fabrication
Bolek, David ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
1 Summary In the thesis are in details described various methods of pharmaceutical nanoparticles preparation, their surface properties and incorporated drug release. Some relevant data concerning prospective use of nanosystems in pharmacotherapy are presented. The main orientation of the thesis is towards experimental laboratory working. Experiments are supported by the use of Nanosizer and Zetasizer device. Nanoparticles with the size under 200 nm from various oligoesters with the linear and branched constitution of carrier molecules were fabricated. The aim of the thesis was focused on stability of size and surface charge parameters during their storage under different thermal conditions and under static and dynamic state of hydrophilic external phase after preparation process. Liquid systems containing freshly prepared nanoparticles were spray dried with the mannitol used as additive. The processes including range of stress factors, such as mannitol as osmotic agent dissolution, spray drying operation, and nanoparticles contained in microparticles in aqueous medium dispersion were evaluated from the point of view of size and zeta potential parameters. It was concluded from the experimental results that method based on spray drying of nanoparticular systems and incorporation of nanoparticles into the...
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Universal Full-Text Index
Švantner, Marek ; Skopal, Tomáš (referee) ; Holub, Martin (advisor)
This diploma thesis deals with the design and implementation of a highly efficient universal index of textual documents. Universal stands for an opportunity to configure structures of index records and methods of the index data processing (without recompiling an application). Furthermore, it means that the index library can be used even for other purposes, for example to implement a thesaurus, to represent bibliographic relationships or even for generic representation of a specific class of functions in other areas than documentographic systems. The index is implemented using the dynamic inverted file which can be efficiently updated without need of the data structure rebuilding. Specific issue is on-line index compression and failure recovery via the transactional log. It is shown that the amortized complexity of the data structure is linear. This fact is afterwards experimentally verified. Other experiments address the compression methods and the impact of the data structure parameters on its efficiency. The diploma thesis contains the implementation of the universal index in C/C++. It has been tested in the Linux and Windows XP environments.
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HyperCuts pro filtrování Linuxových paketů
Mašíček, Viktor ; Peterka, Jiří (referee) ; Kučera, Luděk (advisor)
Filtering of packets by multidimensional cutting is one of the new approaches to the solution of the packet classiffication problem. It is based on creating a tree that contains the set rules of filtering. In this case a packets matching is considerably faster than linear traversing of all rules. The HyperCuts methods are one of the latest methods that use multidimensional cutting. At first sight the implementation of the HyperCuts method demonstrated its utility. However, the final decision about the usage of the HyperCuts program in practice can be made only on the basis of the results of testing in it is necessary to can be using in a practice it have to be tested in practical operation. In comparison with the PTree program, which is based on the TBF method, the HyperCuts program, was more successful. The comparison was based on resolving the problem rather than on implementation aspect or success with the same data. In case, where we use PTree source code for confrontation, we compare it with source code of HyperCuts from our implementation. We compare time and memory complexity. In the theoretic part there is explain why the "range match" was used. There is definition of term "cut" which is very advantageous for time and memory complexity. One of the goals of the work was HyperCuts method...
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Boolean algebras and first order theories.
Cepák, Jiří ; Pajas, Petr (referee) ; Mlček, Josef (advisor)
We will study Lindenbaum algebras and algebras of definable subsets of selected first order theories: constants theory for a, Presburger, Robinson, Peano and standard arithmetic, successor theory, successor theory with zero, theory of dense linear orders without endpoints, theory of discrete linear orders, random graph theory and theory of algebraically closed fields. For finite algebras we will determine their cardinality, for countable algebras we will determine whether they are atomic or atomless and for some of them we will carry out classification up to isomorphism using algebras FA, ASA and CA. For this purpose we will prove several general theorems.
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Modification the plan of construction of linear structures
Mudrák, Miroslav ; Kocanda,, Pavel (referee) ; Nový, Martin (advisor)
Submitted thesis deals with planning of an implementation of a linear construction by using the contract conditions. The theoretical describes the topics of project management, engineering, procurement and traffic politics of Czech Republic. It also describes the history, status and development of the highway network. In the end there is introduced the modernized section of the D1 highway. The practical part deals with the application of the modified project Modernization solutions to the D1 highway - section 22 by introducing a shift operation during the construction. It solves the impact of shift work on phasing construction schedule, financial plan and compares the positive aspects of the solutions against the negative ones. In conclusion there is an evaluation effectiveness of the actual and modified variants of the construction.
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Traditional and modern approaches to pricing in nonlife insurance
Vojtěch, Jonáš ; Branda, Martin (advisor) ; Mazurová, Lucie (referee)
Title: Traditional and modern approaches to pricing in nonlife insurance Abstract: This thesis deals with the theory and implementation of generalized linear models in the area of pricing of non-life insurance and subsequent optimalization of rates. Using the generalized linear models it is possible to estimate expected value and variance of compound distribution of total claims made according to insurance policy during definite time period. The next step is to build an optimalization model and describe several methods how to determine rates that lead to optimal distribution of safety margins within insurance policies in particular risk groups. Represented approaches how to calculate insurance premiums are numerically illustrated on simulated data in concluding parts of the thesis.
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Head Pose Estimation from Photography
Szentandrási, Tamás ; Juránek, Roman (referee) ; Behúň, Kamil (advisor)
The aim of this work is to propose and implement a head pose estimation system using Random Forests, with photographic input. This work uses a version on Random Forests with using Fisher Linear Discriminant Analysis for node splits. It also uses a number of tools to achieve this goal, the OpenCV library, SQLiteCpp library, and the aflw database. This work created an accurate head pose estimation system reusable for future Computer Vision tasks.
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Drive Vertical Saddle of Machining Centre by Linear Motor
Zapletal, Radek ; Andrýsek, Radim (referee) ; Foller, Bronislav (advisor)
The diploma dissertation deals with the mechanism of vertical movement of a saddle of high-speed machining centre which is made by the Trimill company. The movement of vertical alloy saddle is solved by ball screw. The solution could be improved by replacing the ball screw by linear motor. This will dramatically improve the dynamics of the movement of the vertical saddle. In addition, if the weight is compensated by pneumatic relief and the construction is welded, the dynamics will further improve.
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Economics of Microbrewery
Šplíchalová, Jitka ; Maier, Tomáš (advisor) ; Lukáš, Lukáš (referee)
The main aim of this diploma thesis is to evaluate economy of chosen Microbrewery XY, Ltd. in observed period 2012 till 2015. Economy of microbrewery is evaluated on the bases of methods of financial analysis and costs calculation per unit of production.
The thesis is divided into theoretical and practical part. Theoretical part deals with history of breweries, categorization of microbrewery and its characteristics. Also in this work is described process of beer production and ingredients necessary for its production. This part includes methods and formulas used for financial analysis and costing.
Practical part deals with characteristics of microbrewery production. Simple Linear Regression model verifies the seasonality in beer consumption. To accomplish the main aim are used methods of financial analysis and costing. Financial analysis consists horizontal and vertitical analysis, differential and ratio indicators, creditworthy and bankruptcy models evaluating whole financial situation of the microbrewery.
In chapter Evaluation of the results and Conclusion are summarized results, an overall evaluation of microbreweries economy and are proposed recommendations for improving its economy.
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