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Influence of alloying elements on the solubility of titanium in magnesium alloys
Matocha, Martin ; Buchtík, Martin (referee) ; Březina, Matěj (advisor)
This bachelor's thesis examines the influence of alloying elements on the solubility of titanium in magnesium alloys. In the theoretical part, a literature review was conducted on the topics of the creation, composition, processing, and brief analysis possibilities of magnesium alloys, with an emphasis on the potential for alloying magnesium alloys with titanium. The experimental part focused on the preparation of systems with various compositions to achieve the integration of titanium into the magnesium alloy. After preparation of the samples of the given systems, their analysis was performed using SEM/EDS and XRD. Based on the ongoing results of the samples analysis, efforts were made to optimize the holding time of the samples of the given system at a temperature of 905°C. It was found that during the stabilization of the modification of titanium, it is possible to achieve mixing of titanium, zinc, and magnesium. The condition for the formation of the modification of titanium is the highest possible temperature allowed by the system. However, the temperature must exceed at least 881°C. The stability of the modification of titanium is also supported by the absence of alloying elements that promote the stability of the modification of titanium. The mixture of elements in the aforementioned system has not yet been described in the scientific literature.
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Continual double-helicoidal mixer
Černý, Jan ; Malach, František (referee) ; Malášek, Jiří (advisor)
This work focuses on the process of mixing particulate materials and the design of the screw mixer for this activity. The theoretical part describes the mixing and properties of particulate matter. Subsequently, individual devices serving for different types of mixing are analyzed. The practical part contains calculations of the main dimensions and the required power consumption. The choice of suitable drive, bearings and gear is followed. Finally, the analysis of the blade shaft load and the strength analysis of the mixer blade using Autodesk Inventor are performed. Part of this work is enclosed drawing documentation of equipment assembly and selected partial components.
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Two shaft continuous mixer
Lukuvka, Šimon ; Malach, František (referee) ; Malášek, Jiří (advisor)
This diploma project solves questions of blending processes and mixers of partikular materials. In the first and the second part is solved theoreticel analysis of blending processes. Contain of the third and the fourth part is designing and calculating of the mixer´s parameters.
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Continual double-helicoidal mixer
Černý, Jan ; Malach, František (referee) ; Malášek, Jiří (advisor)
This work focuses on the process of mixing particulate materials and the design of the screw mixer for this activity. The theoretical part describes the mixing and properties of particulate matter. Subsequently, individual devices serving for different types of mixing are analyzed. The practical part contains calculations of the main dimensions and the required power consumption. The choice of suitable drive, bearings and gear is followed. Finally, the analysis of the blade shaft load and the strength analysis of the mixer blade using Autodesk Inventor are performed. Part of this work is enclosed drawing documentation of equipment assembly and selected partial components.
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Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug
Veselá, Eliška ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Eliška Veselá Title of Thesis: Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug The aim of this thesis was to enhance the solubility of a poorly soluble model drug meloxicam (MLX) by preparing binary interactive mixtures with hydrophilic carriers by simple mixing and co-milling. The mixtures were characterized for granulometric properties. The dissolution studies were carried out using the USP-4 apparatus assembled with a flow-through powder cell in an open-loop system. The dissolution rate rrel (min-1 ) and the amount of released drug mrel (%) were evaluated. The observable positive effect of carriers was registerred in terms of increasing the dissolution rate and the amount of released drug for both mixed and co-milled mixtures comparing to the raw drug. Mixtures with hypromellose were the exception; the improvement of the monitored parameters was not detected.
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Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug
Veselá, Eliška ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Eliška Veselá Title of Thesis: Study of influence of hydrophilic carriers on the solubility of a poorly soluble drug The aim of this thesis was to enhance the solubility of a poorly soluble model drug meloxicam (MLX) by preparing binary interactive mixtures with hydrophilic carriers by simple mixing and co-milling. The mixtures were characterized for granulometric properties. The dissolution studies were carried out using the USP-4 apparatus assembled with a flow-through powder cell in an open-loop system. The dissolution rate rrel (min-1 ) and the amount of released drug mrel (%) were evaluated. The observable positive effect of carriers was registerred in terms of increasing the dissolution rate and the amount of released drug for both mixed and co-milled mixtures comparing to the raw drug. Mixtures with hypromellose were the exception; the improvement of the monitored parameters was not detected.
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Continual double-helicoidal mixer
Černý, Jan ; Malach, František (referee) ; Malášek, Jiří (advisor)
This work focuses on the process of mixing particulate materials and the design of the screw mixer for this activity. The theoretical part describes the mixing and properties of particulate matter. Subsequently, individual devices serving for different types of mixing are analyzed. The practical part contains calculations of the main dimensions and the required power consumption. The choice of suitable drive, bearings and gear is followed. Finally, the analysis of the blade shaft load and the strength analysis of the mixer blade using Autodesk Inventor are performed. Part of this work is enclosed drawing documentation of equipment assembly and selected partial components.
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Continual double-helicoidal mixer
Černý, Jan ; Malach, František (referee) ; Malášek, Jiří (advisor)
This work focuses on the process of mixing particulate materials and the design of the screw mixer for this activity. The theoretical part describes the mixing and properties of particulate matter. Subsequently, individual devices serving for different types of mixing are analyzed. The practical part contains calculations of the main dimensions and the required power consumption. The choice of suitable drive, bearings and gear is followed. Finally, the analysis of the blade shaft load and the strength analysis of the mixer blade using Autodesk Inventor are performed. Part of this work is enclosed drawing documentation of equipment assembly and selected partial components.
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