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Benchmark of the Computational Tools for the Prediction of the Effect of Mutations on Protein Stability
Berezný, Matej ; Martínek, Tomáš (referee) ; Musil, Miloš (advisor)
Návrh proteínov vyžaduje informáciu o tom ako mutácie ovplyvňujú celkovú stabilitu proteinu. Pre tento prípad existuje mnoho verejne dostupných nástrojov avšak ich kolektívne používanie či porovnávanie je veľmi pracné. Presne pre tento prípad som vyvinul BenchStab; konzolovú aplikáciu/Python knižnicu navrhnutú pre rýchlu a priamočiaru manipuláciu s 18 prediktormi, umožňujúc hromadné získavanie mutačných výsledkov. Zároveň som vytvoril novú unikátnu dátovú sadu, získanú z FireProtDB. Tento dataset som použil na porovnanie 24 rôznych predikčných metód pomocou rôznych metrík.
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Models for Predicting Business Financial Performance
Vakhrushev, Dmitrii ; Oulehla, Jiří (referee) ; Luňáček, Jiří (advisor)
The thesis focuses on models for predicting the financial performance of the ALZA company, where it focused on emphasizing the strong financial performance and stability of the company. Key factors contributing to ALZA's success will be mentioned, such as consistent revenues, profits, effective cost management and investment in innovation. In addition, the work would also focus on potential strategies for further growth, such as exploring new markets, strengthening online sales, diversifying product offerings, and strengthening relationships with customers and suppliers. Emphasizing the importance of continuous innovation, market monitoring and strategic investment will demonstrate ALZA's readiness for future success and market expansion.Using financial data for the period 2017 to 2022, market trends and industry benchmarks, accurate predictions can be made regarding ALZA's future financial results. Implementing advanced modelling techniques and incorporating different scenarios can provide valuable insights for strategic decision-making.
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Optimization of Combined Chitosan Particles and their Characterization for Cosmetic use
Mrůzková, Barbora ; Dzurická, Lucia (referee) ; Bendová, Agáta (advisor)
The bachelor thesis focused on optimizing preparation and characterization of chitosan coated liposomes with selected active substances and their use for cosmetic applications. The theoretical part of the thesis describes natural substances, their effect on the skin, encapsulation methods, and the preparation and use of liposomes and chitosomes. In the experimental part, the optimization of the preparation of liposomes and chitosomes and their subsequent characterization by measuring particle size, polydispersity index, zeta potential, encapsulation efficiency and gradual release of active substances were performed. The selected active substances in this work were vitamin C, -carotene, caffeine and vitamin E. From the data obtained, the method of adding liposomes dropwise into the 2% chitosan with a short mixing time and ultrasonication for 1 minute was selected as the most suitable method for the preparation of chitosomes usable in cosmetics. Furthermore, the encapsulation efficiency of the particles and the antioxidant capacity of vitamin C, -carotene, caffeine and vitamin E were compared. The best antioxidant properties were determined for vitamins C and E; therefore, the gradual release of chitosomes with these active substances was subsequently measured in an environment simulating cosmetics. At the end of the work, cosmetic emulsions and gels containing selected chitosomes were prepared and tested on the skin by determining changes in desquamation.
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Center for seniors in Brno-Medlánky
Otépka, Petr ; Klimecký, Martin (referee) ; Gerö, Jiří (advisor)
The architectural study for the elderly home follows on the urban-architectural study conducted in the previous semester as a part of the NGA056 – Specialised Studio course. The study resulted in a compact urban development with mix of functions. It includes not only housing, commerce, public buildings, the church, the sport hall and transport facilities, but also a block of centre for elderly. The architectural study is focused on creating a complex centre with good supply of services, amenities, privacy and, most importantly, quality spaces. The design is based on the concept of compactness. All pavilions which are full of spatial and operational requirements form a block and inner courtyard. The inner courtyard is situated above the underground parking, and it is adjacent to a park, connected to it by a ‘neck’. The park opens to the southwest and its borders are defined by the centre on the east and apartment building for elderly on north side. On the side which faces the centre of the new district, the block turns on its ground floor, accommodating a café, entrances and other services. It facilitates connection with the community, together with park on the opposite side. The proposal presents a contemporary perspective on housing for the elderly in our society. The spaces try to have their own identity, with which residents or clients can identify and accept a room or apartment as their home, rather than just a final stop on their life’s journey.
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The applications of differential equations in the temperature regulation
Horáček, Jan ; Švarc, Ivan (referee) ; Dosoudilová, Monika (advisor)
This bachelor's thesis deals with the importance of differential equations in control theory. The review section is devoted to a reminder of the mathematical apparatus of linear differential equations and the methods of solving them, including the characteristic equation and the Laplace transform. Furthermore, the research part deals with control, transfer function and stability. The final section is devoted to the solution of a real room temperature change problem including software verification.
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Stability of non-linear mechanical systems
Hrabec, Martin ; Řehák, Pavel (referee) ; Opluštil, Zdeněk (advisor)
This thesis deals with stability analysis of non-linear mechanical systems. Firstly there are introduced basic concepts of non-linear dynamical systems and stability. The theory of deterministic chaos and Lypunov exponents is described next. Numerical calculations focused on indication of chaotic behaviour are presented as well.
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Possibilities of hippotherapy in spasticity therapy in children with cerebral palsy
VOLŠINSKÁ, Monika
This bachelor's thesis discusses the possibilities of hiporehabilitation of spastic paresis of lower limbs in children with cerebral palsy. In clinical practice, they are used for therapy concepts on a neurophysiological basis. The main methods are Vojtova reflexive therapy and the Bobath concept, which are irreplaceable for the rehabilitation treatment of DMO. In this work I focus on complementary therapy in the form of hiporehabilitation. This method uses repetitive, rhythmic and regular stimuli for the central nervous system. Summation stimuli subsequently plasticity of the brain and helps for greater effectiveness of the treatment. The theoretical part is focused on the issue of cerebral palsy. Introducing definition, causes and symptoms including central nervous system involvement system, which is manifested by increased muscle tension. Thesis therefore also describes origin and manifestations of spasticity and the scale that evaluates spasticity. Spasticity can be controlled by hiporehabilitation, which I introduce in detail in the theoretical part of my work. Methodical part describes the data collection procedures that are used for research. The practical part proceeds in the form of qualitative research of a case study in which two probands participated and were diagnosed with a spastic form of cerebral palsy. An input and output kinesiology analysis was performed for individual probands, which includes anamnesis, physical examination of aspects and palpation, goniometry, walking tests-TUG, 2MWT and 10MWT. The modified Ashworth scale was used to evaluate the spread of spasticity. The entire research took place during a one-week hiporehabilitation stay. The results of therapy were used to compare input and output kinesiology analysis, which shows a positive trends in the effect of the therapy. Both probands showed a slight improvement in stability and posture, walking speed and regularity. Positive influence on spasticity was reflected by a change in pelvic position and a slight increase in the range of motion of the lower limbs. Hiporehabilitation alleviated the symptoms of muscle hyperactivity and therefore represents an opportunity to extend physiotherapy in children with cerebral palsy.
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Study of stability of antimicrobial nanomaterials in different environment by HPLC
Janderová, Šárka ; Trachtová, Štěpánka (referee) ; Márová, Ivana (advisor)
This thesis deals with the preparation of nanomaterials (nanoparticles, nanofibers) with encapsulated active substances and the stability of these nanomaterials in different environments using liquid chromatography. The development and optimization of methods for monitoring the kinetics of release of encapsulated substances from nanomaterials into various environments play a key role in research aimed at their utilization in the pharmaceutical, food, and cosmetic industries, and also contribute to the development of new antimicrobial nanomaterials limiting antibiotic resistance. The theoretical part focuses on the characterization of nanomaterials (nanoparticles, liposomes, nanofibers, and combined nanomaterials). Another section of the literature review deals with natural (eugenol, carvacrol, curcumin, thymol, vitamin E) and synthetic (ampicillin, streptomycin) antimicrobial substances. The final chapter discusses the instrumental methods used for the characterization of nanomaterials and the evaluation of their stability, released, and degradation products. In the practical part, the antioxidant activity of selected substances was first monitored. Liposomes were prepared, and their stability and encapsulation efficiency were examined. An HPLC method for determining active substances was optimized. Subsequently, the gradual release of the mentioned active substances from prepared liposomes was monitored. Nanofibers were prepared using forcespinning, and their release into selected model environments was also analyzed. Distilled water with minimal ion and impurity content served as a model environment, as well as a physiological solution at 25°C, simulating the temperature of the human body surface, and a physiological solution at 37°C, characteristic of human body temperature. This analysis provides a comprehensive view of the behavior of prepared materials and their potential practical applications. In the final section, combined nanomaterials (based on nanofibers and nanoparticles) with encapsulated active substances were prepared. The gradual release of active substances and any potential synergistic effects were examined for these nanomaterials.
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Furniture in symbiosis with plants
Paterová, Eva ; Landa Filípková, Valentýna (referee) ; Tobola, Ondřej (advisor)
The master‘s thesis deals with the design of furniture that serves to connect interiors with nature, especially with plants. At a time when many of us spend most of our time indoors, there is a growing desire to incorporate nature into our homes and workspaces. This thesis analyses historical and contemporary trends in the design of furniture intended for plants and highlights the possibilities for their further development. The aim is to identify and overcome the existing shortcomings in current solutions and, based on this analysis, to propose an innovative prototype that better meets the current needs and aesthetic preferences of users.
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Stability of the Zero Solution of Stochastic Differential System
Klimešová, Marie
Stability of stochastic differential equations (SDEs) has become a very popular theme of recent research in mathematics and its applications. The method of Lyapunov functions for the analysis of qualitative behavior of SDEs provide some very powerful instruments in the study of stability properties for concrete stochastic dynamical systems, conditions of existence the stationary solutions of SDEs and related problems.
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