National Repository of Grey Literature 32 records found  previous11 - 20nextend  jump to record: Search took 0.01 seconds. 
Syntéza modifikovaných nukleosidů a oligonukleotidů nesoucích bipyridinové a fenanthrolinové ligandy
Vrábel, Milan ; Rosenberg, Ivan ; Hocek, Michal
Cross-coupling reactions of 8-halopurines with ethynyl or phenylene-substituted bipyridine ligands gave the title compounds.
Pyrrolidinová analoga nukleotidů - konformační studie
Pohl, Radek ; Rejman, Dominik ; Kočalka, Petr ; Rosenberg, Ivan
Conformation analysis of pyrrolidine ring for series of pyrrolidine nucleotide analogue using concept of pseudorotation and experimental 3J(H,H) coupling constants was performed.
Syntéza 4'-N pyrrolidinových nukleosidů, nukleotidů a oligonukleotidů
Rejman, Dominik ; Kočalka, Petr ; Pohl, Radek ; Rosenberg, Ivan
Synthetic routes to novel pyrrolidine nucleoside, nucleotide, and oligonucleotide analogues, where C-4‘ carbon atom of ribose is replaced with nitrogen atom of pyrrolidine have been developed.
Nové nukleosidfosfonové kyseliny jako inhibitory thymidinfosforylázy
Kočalka, Petr ; Rinnová, Markéta ; Vaněk, Václav ; Rejman, Dominik ; Votruba, Ivan ; Tomečková, Ivana ; Králíková, Šárka ; Petrová, Magdalena ; Páv, Ondřej ; Pohl, Radek ; Buděšínský, Miloš ; Liboska, Radek ; Točík, Zdeněk ; Rosenberg, Ivan
Several sugar-modified thymine-containing nucleoside phosphonic acids were found as a strong inhibitors of thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain.
Oligo-3'-deoxynukleotidy s chirální alfa-hydroxyfosfonátovou 2',5' internukleotidovou vazbou: zlepšení hybridizační selektivity vůči RNA?
Králíková, Šárka ; Buděšínský, Miloš ; Liboska, Radek ; Páv, Ondřej ; Rosenberg, Ivan
Synthesis and hybridization selectivity of 9-mers 5’-d(GTG ATA TGC)-3’ (T means modified units) containing both hydroxyphosphonate and phosphodiester 2’-5’ internucleotide linkages toward complementary DNA and RNA counterpart were investigated.
Monomery pro nové fosfonátové oligonukleotidy, potenciální inhibitory RNasy L
Liboska, Radek ; Páv, Ondřej ; Rosenberg, Ivan
Synthetic route for the preparation of 2',3'-O-phosphonoalkylidene , and 3',5'-O-phosphonoalkylidene ribonucleotide monomers for automated oligonucleotide synthesis (a phosphotriester condensation approach) has been developed.
Izopolární, izosterní 4'-substituované 2',5'-oligoadenyláty jako potenciální aktivátory RNasy L
Pačes, Ondřej ; Rosenberg, Ivan
Synthesis of two different monomers usable for solid phase synthesis of two basic types of phosphonate and phosphodiester 2’,5’-oligoadenylates as potential activators of RNase L is reported.
Isosterní fosfonátová internukleotidová vazba typu 3'-O-P-CH2-O-4'C: Cesta k dalším údajům o její stereochemii
Točík, Zdeněk ; Barvík, I. ; Buděšínský, Miloš ; Rosenberg, Ivan
Synthesis of model thymidine dinucleoside phosphonate containing 3´-O-P-CH2-O-4´C isosteric linkage in 13C-labelled form enabled its NMR conformational description which was further compared with MDS and ab initio studies.
Syntéza monomerů pro prolinolové oligonukleotidy
Vaněk, Václav ; Buděšínský, Miloš ; Rosenberg, Ivan
A series of prolinol-based modified nucleotide monomers with phosphonomethyl or phosphonoformyl group attached to the pyrrolidine nitrogen was prepared; the monomers will be used for solid phase synthesis of oligonucleotide analogues.

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