Národní úložiště šedé literatury Nalezeno 2 záznamů.  Hledání trvalo 0.01 vteřin. 
Activation of human RNase L by 5’-C-phosphonate-modified oligoadenylates
Petrová, Magdalena ; Buděšínský, Miloš ; Zborníková, Eva ; Panova, Natalya ; Novák, Pavel ; Rosenberg, Ivan
Adeno’sine 5’-(S)-C-phosphonate (pCOHX) was prepared as monomer suitable for oligonucleotide synthesis. Modified tetramers pCOHXAAA and pCOHXAApCOHX were assembled on solid phase and evaluated for their ability to activate human RNase L.
Insights into the mechanism of action of bactericidal lipophosphonoxins
Panova, Natalya ; Zborníková, Eva ; Šimák, Ondřej ; Krásný, Libor ; Kolář, M. ; Látal, T. ; Seydlová, G. ; Rejman, Dominik
The advantages offered by antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of antibiotic-resistant bacterial strains. This reduces the efficiency of antibiotic treatments and poses a serious health and economical problem. Currently, the need for novel antibiotics is becoming increasingly apparent. Recently, we discovered a series of compounds termed lipophosphonoxins exhibiting selective cytotoxicity towards gram-positive bacterial cells. The attempt to elucidate the mode of action of lipophosphonoxins is presented here.

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