National Repository of Grey Literature 5 records found  Search took 0.01 seconds. 
Protein kinase C ε and δ in chronically hypoxic heart
Kožichová, Kristýna ; Martínková, Markéta (referee)
1 Abstract Adaptation to chronic hypoxia confers long-term cardioprotective effects. We have shown, that protein kinase C (PKC) is involved in this cardioprotective phenotype. It has not been elucidated, which PKC isoform plays a role, but the most likely candidates are PKC ε a PKC δ. Therefore, the aim of this study was to analyze the expression and localization of PKC ε and PKC δ after the adaptation to chronic hypoxia. We have shown that adaptation to chronic hypoxia caused the activation and tranlocation of PKC δ to the mitochondrial and sarcolemmal membranes. Our study suggests that PKC δ plays an important role in the mechanism of cardioprotection induced by chronic hypoxia.

Interested in being notified about new results for this query?
Subscribe to the RSS feed.