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Analytical Derivatization for Identification of Electrochemical Oxidation Products of Fentanyls
Barták, P. ; Skopalová, J. ; Jerga, R. ; Štolbová, D. ; Navrátil, Tomáš ; Langmaier, Jan
Analytical derivatization and GC-MS analysis were employed for the identification of main\nproducts from the electrochemical oxidation of fentanyl derivatives. Chemical derivatization\nprovides proof of the chemical reactivity of functional groups in oxidation products and serves\nfor the chemical conversion of target compounds into the second series of derivatives to confirm\nthe identification of particular products. Using the direct GC-MS analysis of oxidation products,\nderivatization of aldehydes with cysteamine and derivatization of amides by acidic hydrolysis\nand subsequent reaction with ethylchloroformiate, phenylacetaldehyde, and Nphenylpropanamide\nwere unambigously identified as oxidation products from fentanyl,\nthiophen-2-ylacetaldehyde, and N-phenylpropanamide from sufentanil, and\nphenylacetaldehyde and 2-furanilid from furanylfentanyl.

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