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Ovarian carcinomas - the influence of the Rho kinase family on cell migration
Barešová, Veronika ; Urbánková Rathouská, Jana (advisor) ; Fikrová, Petra (referee)
Author: Veronika Barešová Title: Ovarian carcinomas - the influence of Rho family kinases on cell migration Diploma thesis Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Ovarian carcinomas are the deadliest group of gynecological malignancies. This is due to a high rate of metastasis and acquired drug resistance. Metastasis is characterized by a phenotypic change of cells from epithelial to mesenchymal, resulting in the loss of cell-cell and cell-extracellular matrix contacts and subsequent cell movement. This process is called epithelial-mesenchymal transition and has been shown to also play a role in cell resistance to cisplatin. The movement of individual cells is mediated by the Rho GTPase family and can be divided into mesenchymal and amoeboid types. The amoeboid type is characterized by the Rho/ROCK signaling pathway, while mesenchymal movement is mediated by the Rac/Cdc42 pathways. In my thesis, we investigated the differences in expression of selected proteins in both signaling pathways in ovarian carcinoma cells. Initially, we focused on comparing the A2780 and A2780cis cell lines, which are resistant to cisplatin. We monitored markers of amoeboid movement, RhoA and phosphorylated myosin, and markers of mesenchymal movement, Wave-2,...
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Measuring Financial Instability: A Survey
Urbánková, Jana ; Baxa, Jaromír (advisor) ; Kolouchová, Petra (referee)
This thesis aims to analyze how various theoretical definitions describe and assess financial stability, and how these definitions are actually being reflected in the measurement methods used to evaluate financial stability. The first section lists different theoretical approaches to defining financial stability, extrapolates main components that characterize these approaches, and compares these approaches based on the components. The thesis continues with a description and critical assessment of financial stability measurement methods. Special attention is paid to financial conditions and financial stress indexes, which are compared based on actual data for the United States. The last section explores to what extent these components are compatible with financial stability measurement methods listed in the previous section. This thesis also points out that most methods measure financial instability, as opposed to financial stability, perhaps because instability is less abstract and, thus, more convenient for an effective measurement. The thesis concludes that recent quantitative assessments of financial stability are real time assessments rather than strong predictive indicators of financial (in)stability and, thus, they do not offer policymakers enough time and information for timely policy...
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Teambuilding of travel agency CK Lenka
Šoubová, Tereza ; Janák, Vladimír (advisor) ; Urbánková, Jana (referee)
Název práce: Budování týmu CK Lenka, s. r. o. Title of work: Teambuilding oftravel agency CK Lenka Cíl práce: Hlavním cílem této práce je pomocí teambuildingového kurzu vytvořit fungující tým , který je schopný spolupráce, komunikace, důvěřuje si a je pozitivně motivován. Přesněji také, vybrat vhodné aktivity tak, aby do sebe smysluplně zapadaly, vhodně navazovaly a aby se jejich účinek rozvíjel cíleným směrem. Metody: V práci bylo využito strukturované interview, workshop a pozorování. Dále bylo pro závěrečná hodnocení využito dotazníku. Výsledky: Práce přináší návod, jak je možno řešit problémy v týmu. Klíčová slova: Teambuilding, komunikace, management, spolupráce, tým
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The Macro-finance Model of the Czech Economy
Urbánková, Jana ; Baxa, Jaromír (advisor) ; Cahlík, Tomáš (referee)
The thesis introduces the macro-finance model of the Czecheconomy by setting the VAR model, which includes components representing theyield curve estimatedwithin theNelson-Siegel framework. The thesis contributes to the current streamof researchby including both the policy interest rateand the interbank interest rateas endogeneous variables in the VAR model, which allows for differentiation between monetarypolicy shocks and shocks to interbank rates. The above-mentioned model then serves as a frameworkfor analyzing interactions betweenfinancial and macroeconomicvariables in the period from 2000 to 2015. The thesis pays special attention to theperiod 2008-2013 and shows that the introduction of the FX commitment in November 2013 had a significant positive effect on GDP and inflation within 12 months after the introduction of the FX commitment. The thesis concludes that exchangeratemovements affectedalmost uniformly short-term and long-terminterest rates, and thus the yield curve slope stayed largelyunaffected by exchangeratemovements.
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