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Development of Business Activities of Company
Červenka, Ondřej ; Sýkorová, Martina (referee) ; Zich, Robert (advisor)
This bachelor thesis – Development of business activities of company – analysis current position of the company. It also deals with inside and outside environment that influences business activities. By the inside and outside analysis of environment there are formulated Opportunities and Threats and below Strengths and Weaknesses. Finally there is put together SWOT matrix. The matrix results in proposals of development of business activities of company.
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Study on impact of selected tyrosine kinase inhibitors on multidrug resistance mediated by ABC drug efflux transporters
Sýkorová, Martina ; Hofman, Jakub (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Martina Sýkorová Supervisor: RNDr. Jakub Hofman, Ph.D. Title of diploma thesis: Study on impact of selected tyrosine kinase inhibitors on multidrug resistance mediated by ABC drug efflux transporters Tyrosine kinases are an important class of enzymes controlling cell proliferation, carcinogenesis, apoptosis and cell differentiation. Deregulation of these enzymes can transform normal cell into a cancerous one. Blocking their function by tyrosine kinase inhibitors (TKi) is considered a promising treatment for various types of cancer. ATP-binding cassette (ABC) transporters form a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes via ATP-dependent drug efflux pumps. They modulate drug pharmacokinetics, but on the other hand, lead to therapy failure due to overexpression in cancer cells. In our previous study, we evaluated inhibition properties of two selected TKi (alectinib, brivanib) in MDCKII cell lines (parent one and those transduced with human ABCB1, ABCC1 and ABCG2). Alectinib significantly inhibited ABCB1, ABCG2 but not ABCC1 transporter. Brivanib showed triple inhibition of all studied transporters. In the present work, we...
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Study on impact of selected tyrosine kinase inhibitors on multidrug resistance mediated by ABC drug efflux transporters
Sýkorová, Martina ; Hofman, Jakub (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Martina Sýkorová Supervisor: RNDr. Jakub Hofman, Ph.D. Title of diploma thesis: Study on impact of selected tyrosine kinase inhibitors on multidrug resistance mediated by ABC drug efflux transporters Tyrosine kinases are an important class of enzymes controlling cell proliferation, carcinogenesis, apoptosis and cell differentiation. Deregulation of these enzymes can transform normal cell into a cancerous one. Blocking their function by tyrosine kinase inhibitors (TKi) is considered a promising treatment for various types of cancer. ATP-binding cassette (ABC) transporters form a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes via ATP-dependent drug efflux pumps. They modulate drug pharmacokinetics, but on the other hand, lead to therapy failure due to overexpression in cancer cells. In our previous study, we evaluated inhibition properties of two selected TKi (alectinib, brivanib) in MDCKII cell lines (parent one and those transduced with human ABCB1, ABCC1 and ABCG2). Alectinib significantly inhibited ABCB1, ABCG2 but not ABCC1 transporter. Brivanib showed triple inhibition of all studied transporters. In the present work, we...
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How does the profession on of a nurse influence the quality of her life?
Sýkorová, Martina ; Pečenková, Jaroslava (advisor) ; Šlaisová, Ivana (referee)
Author: Martina Sýkorová Institution: Charles University in Prague, Medical faculty of Hradec Králové, Institute of social medicine, Department of nursing Title of thesis: How does the profession on of nurse influence the quality of her life Consultant: Jaroslava Pečenková Number of pages: 97 Number of appendices: 4 Year of defense: 2012 Key words: Quality of life, profession, profession of a nurse's The thesis deals with the professional influence at a private life of a nurse. In the opening part are described beliefs about the quality of life in general and factors which affect it. The following part contains social aspects of of nursing as a profession in the history, the beginning of Czech nursing education. There are also described working conditions, a nursing uniform formation. In the empiric part were set down goals and related appropriate hypothesis.Two questionnaires were made - for nurses and family members .The results were recorded into charts and graphs. The main task in the empiric part was to authenticate the correctness of the hypothesis and fulfilling the given goals. One of the main goals was to find out how the nursing carrer affects her personal life.
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Development of Business Activities of Company
Červenka, Ondřej ; Sýkorová, Martina (referee) ; Zich, Robert (advisor)
This bachelor thesis – Development of business activities of company – analysis current position of the company. It also deals with inside and outside environment that influences business activities. By the inside and outside analysis of environment there are formulated Opportunities and Threats and below Strengths and Weaknesses. Finally there is put together SWOT matrix. The matrix results in proposals of development of business activities of company.
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Credit unions in the Czech Republic and their importance in the context of loan products
Sýkorová, Martina ; Radová, Jarmila (advisor) ; Matejašák, Milan (referee)
The thesis is focused on the analysis of credit products offered by the credit unions in the context of Czech retail banking. The objective of the thesis is to compare the terms of specifi c loan products of banks and credit unions. The first part is devoted to the history of credit unions in the Czech Republic since the late 20th century. Then it discusses the various types of products off ered by these institutions. The last part is trying to assess the specifi c terms of the credit products off ered by selected credit unions and banks.
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