|
|
Sports club
Patočka, Jan ; Jedlička, Jaroslav (referee) ; Utíkalová, Ivana (advisor)
Diploma thesis adresses the the project documentation the new building of Sports club in Polička city. It’s an object designed for sports activities to the public with a café and sports shop. The building consists of two floors and one basement floor. The part of object with one floor is for refreshing vitsitors. A basement part with a two floor is used for sports activities. The building is covered with a flat roof and mounted on flat terrain. The total maximum capacity is 104 people.
|
|
|
Family house with an establishment
Patočka, Jan ; Ouda, Jiří (referee) ; Utíkalová, Ivana (advisor)
Bachelor thesis addresses the design documentation for establishment of a house - hairdresser in the village Lubná near the town Polička. The house is designed for a family of five, has two floors and one underground floor. The building is covered with a gable roof, L-shaped building site is planar.
|
|
|
A dividing device in piece production
Patočka, Josef ; Osička, Karel (referee) ; Kalivoda, Milan (advisor)
The main work of the Bachelor‘s thesis is to describe dividing device, function and the manipulation in the piece production. The Bachelor‘s thesis is separated into 3 parts. The first part is about dividing device. The second part is describing piece production of manufacturing technology and the third part is the suggestion of product from author. There is defined design, production process, list of tools and the fotodocumentation of process.
|
|
|
Analysis and use of wire cutting technology
Patočka, Josef ; Osička, Karel (referee) ; Kalivoda, Milan (advisor)
The diploma thesis focuses on the topic of electroerosive machining with greater emphasis on wire cutting technique. The first part clearly describes the principle of electroerosive discharge and its subsequent effects that cause material removal in the given working conditions. This includes the individual methods of electroerosion and the individual accessories that aid the process. The second part is a theoretical analysis of the cutting process using a wire electrode. It describes the machining method, machining strategy and a complete overview of the accessories that accompany the cutting process. The third part of the thesis includes a practical demonstration of the production of a typical representative for wire cutting and then there is evaluation from an economic point of view. Furthermore, there is clear analysis of the surface quality and the final evaluation of the condition of the component.
|
|
|
Interactions of natural phenolic compounds with biogenic metals
Lomozová, Zuzana ; Mladěnka, Přemysl (advisor) ; Bittner Fialová, Silvia (referee) ; Patočka, Jiří (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy and Pharmaceutical Botany Candidate: Zuzana Lomozová, MSc. Supervisor: Prof. Přemysl Mladěnka, PharmD., Ph.D. Title of Doctoral Thesis: Interactions of natural phenolic compounds with biogenic metals Phenolic compounds are one of the most widely distributed groups of secondary plant metabolites. They are an integral part of the human diet and their consumption is associated with a number of positive effects. They include a wide range of substances, from simple molecules such as phenolic acids to large polymeric compounds such as tannins. Because of their structure, which includes, among others, free hydroxyl groups, they are able to interact with biogenic metals and form metal complexes with them. Under normal conditions, the homeostasis of these transition metals in the body is tightly regulated, but it can be disturbed in pathological conditions such as acute myocardial infarction, when the levels of free iron and copper increase as a result of a significant decrease in pH. Similar metal imbalance is observed as well as in inflammatory and neurodegenerative diseases, tumours, or diabetes mellitus. The aim of this dissertation was to find out how these substances react with biogenic metals using in vitro and ex...
|
|
|
Interactions of natural phenolic compounds with biogenic metals
Lomozová, Zuzana ; Mladěnka, Přemysl (advisor) ; Bittner Fialová, Silvia (referee) ; Patočka, Jiří (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy and Pharmaceutical Botany Candidate: Zuzana Lomozová, MSc. Supervisor: Prof. Přemysl Mladěnka, PharmD., Ph.D. Title of Doctoral Thesis: Interactions of natural phenolic compounds with biogenic metals Phenolic compounds are one of the most widely distributed groups of secondary plant metabolites. They are an integral part of the human diet and their consumption is associated with a number of positive effects. They include a wide range of substances, from simple molecules such as phenolic acids to large polymeric compounds such as tannins. Because of their structure, which includes, among others, free hydroxyl groups, they are able to interact with biogenic metals and form metal complexes with them. Under normal conditions, the homeostasis of these transition metals in the body is tightly regulated, but it can be disturbed in pathological conditions such as acute myocardial infarction, when the levels of free iron and copper increase as a result of a significant decrease in pH. Similar metal imbalance is observed as well as in inflammatory and neurodegenerative diseases, tumours, or diabetes mellitus. The aim of this dissertation was to find out how these substances react with biogenic metals using in vitro and ex...
|
|
| |
|
|
Molecular biology investigation of somatostatin receptors in diagnostics of pituitary tumors
Drastíková, Monika ; Beránek, Martin (advisor) ; Fryšák, Zdeněk (referee) ; Patočka, Jiří (referee)
Molecular biology investigation of somatostatin receptors in diagnostics of pituitary tumors The overwhelming majority of pituitary tumors are benign, with 25-30% of them representing clinically non-functioning pituitary adenomas (NFA). The treatment of choice for NFA is transsphenoidal neurosurgery. However, the procedure is often not completely successful and frequently tumor remnants remain, resulting in regrow over the long-term follow-up period. This fact has led to the development of new therapy strategies using pharmacological treatment: somatostatin analogs (SA) and estrogen receptor modulators. SA are effectively used in the treatment of acromegaly, neuroendocrine tumors and Cushing's disease. In contrast, pharmacological treatment of NFA has for the most part been unsuccessful. Low SA effectiveness could be associated with the variable expression of target receptors on the adenomas. The aim of the study was to determine the somatostatin (SSTR subtypes 1-5) and estrogen receptor 1 (ER1) expression profile. To obtain more complex receptor profile expression in the pituitary, we also investigated dopamin receptor 2 (D2R). Methods The group of patients was made up of 105 men and 101 women (20-87 years old; median 61). 144 samples were NFA, 44 growth hormone secreting (GHomas), 9 corticotrophin...
|
|
|
Preparation and evaluation of potential drugs inhibiting mitochondrial enzymes
Benek, Ondřej ; Musílek, Kamil (advisor) ; Patočka, Jiří (referee) ; Opletalová, Veronika (referee)
Preparation and evaluation of potential drugs inhibiting mitochondrial enzymes Summary in English Alzheimer's disease (AD) is the most common cause of senile dementia worldwide. Despite being subject to intensive research, the pathogenic mechanisms of AD are still not fully understood and consequently an effective treatment is yet to be developed. Although the aetiology of AD is still unknown, a build-up of amyloid-beta peptide (Aβ) is considered to play an important role in disease progression. The original amyloid cascade hypothesis proposed that insoluble extracellular plaques were responsible for the majority of Aβ toxicity. This hypothesis has since been refined, as recent data indicates that soluble intracellular oligomers are now responsible for the majority of Aβ induced toxic effects. The mitochondrial dysfunction also plays an important role in the pathophysiology of AD. Aβ was detected inside mitochondria and several mitochondrial proteins were found to interact directly with Aβ. Such interactions can affect a protein's function and cause damage to the mitochondria, which finally results in progression of AD. The background for the experimental part of this dissertation thesis was literature review summarizing current knowledge on mitochondrial proteins directly interacting with Aβ in order to...
|
|
|
Influence of Polyphenolic Substances with Iron Chelating Activity in Model of Acute Myocardial Infarction and Oxidation Stress Induced by Catecholamines
Zatloukalová, Libuše ; Hrdina, Radomír (advisor) ; Tilšer, Ivan (referee) ; Patočka, Jiří (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate Mgr. Libuše Zatloukalová Supervisor Prof. MUDr. Radomír Hrdina, CSc. Title of Doctoral Thesis Influence of polyphenolic substances with iron chelating activity in model of acute myocardial infarction and oxidation stress induced by catecholamines Background and aim: Ischaemic heart disease (IHD) and particularly its most serious form - acute myocardial infarction (AMI) - represents significant health problem in the developed countries with relatively high mortality. Within multifactorial pathogenesis of AMI, reactive oxygen and nitrogen species (RONS) generated by free iron catalytic effect and increased activity of the sympathetic nervous system accompanied with a release of the catecholamines play a significant role. Large doses of the synthetic katecholamine isoprenaline has been used as a suitable experimental model of AMI. AIM is considered as typical form of ischaemic-reperfusion (I-R) injury. RONS, which are excessively released during the first minutes of reperfusion, play a significant role in the pathogenesis of myocardial I-R injury. Free iron significantly increases the process of RONS generation. Use of iron chelators could have protective influence in I-R injury and...
|
guest ::
RSS feed.