National Repository of Grey Literature 4 records found  Search took 0.01 seconds. 
Synthesis of steroid phosphoramidates and studies of their properties
Kouřilová, Kateřina ; Chodounská, Hana (advisor) ; Kasal, Alexander (referee)
Signaling pathway of most important excitatory neurotransmitter - glutamic acid consists of several controllable processes. One of these is modulation of N-methyl-D-aspartate receptor (NMDAR), by endogenous ligands leads to temporary improvement of memory skills and cognitive functions. Positive effects of endogenous or exogenous ligands were also demonstrated on membrane protein Glutamate Carboxypeptidasa II (GCPII). The aim of this work was to prepare steroid derivatives suitable for inhibiting of NMDAR and also GCPII. Steroidal skeleton without substituent at C17 was chosen as a scaffold. The influence of compounds on NMDA receptor will be tested on cultures of human embryonic kidney cells (HEK293) transfected by NR1-1a/NR2B/GFP plasmids of subunits NMDAR. Inhibitory activity on GCPII will be tested on human GCPII with folyl-n-γ-L- glutamic acid as a substrate.
Time of recanalisation of pulmonary circulation after acute pulmonary embolism
Kouřilová, Kateřina ; Lang, Otto (advisor)
Deep vein thrombosis and acute pulmonary embolism are two sides of the same coin. It is , in many cases , a serious condition that requires urgent treatment. But to properly treat the disease , it is necessary to properly identify and Thus early diagnosis . In pulmonary embolism is a problem that the clinical symptoms are nonspecific and can mean a number of other serious and trivial disease . It is therefore the Location: choose the correct methods of investigation , which both confirms the diagnosis with high probability , but at the same time be economically and technically available for all patients. The aim of each medical specialty is preventing the emergence of diseases , so even in the case of thromboembolic disease in the first place its prevention. We know a number of risk factors that contribute to the formation of disease , but we also learned how to prevent them using prophylaxis in risk groups of patients. Great interest for this are mainly surgical Domains because many surgical procedures increases the possibility of deep venous thrombosis and pulmonary embolism . The next step is the secondary prevention, thus preventing recurrent episodes of venous thromboembolism (VTE ) , which may lead to pulmonary hypertension, which only worsens the quality of life of the patient, but may end his...

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3 Kouřilová, Klára
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