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Information System Design
Kolář, Jiří ; Jakubec, Mário (referee) ; Koch, Miloš (advisor)
This thesis discusses informatik systems in companies, their technologies and new trends in hardware domain, used to simplify, speed up and streamline business processes. Consequently thesis deals with the extension of an information system in a real environment, aimed to getting more detailed data, processing and subsequent evaluation to adjustable reports.
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Apartment building
Jakubec, Marek ; Jelínková, Barbora (referee) ; Jelínek, Petr (advisor)
The task of this bachelor's thesis was to process the project documentation for the construction of an apartment building in the city of Brno. The apartment house is a free-standing, with three storeys and no basement. The building is covered with a flat roof. On the 1st floor there are 3 garage spaces, cellars and technical facilities of the building. There are a total of 4 housing units on the 2nd and 3rd floors. On the second and third floors, the structures recede and create terraces in two apartments. The other two apartments have their own balconies. Perimeter masonry is made of ceramic blocks with insulation. The ceiling structure is made of reinforced concrete. The bachelor thesis also contains an assessment of the building in terms of building physics and fire safety.
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Analysis of Economic Indicators Using Statistical Methods
Jakubec, Michal ; Šustrová, Tereza (referee) ; Novotná, Veronika (advisor)
The goal of my bachelor’s thesis is to valorize economic situation and to predict future development of economic indicators using Statistics. This thesis has two main parts – theoretical and practical part. Theoretical part discusses about methods of financial analysis and principles of time series in statistics. In practical part I will analyze current economic situation and I will try to predict future development. And at the end of the thesis I will try to determine suggestions for improving the deficiency.
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Energy-saving building of kindergarten Lískáček
Jakubec, Marek ; Vyhlídalová, Karolína (referee) ; Počinková, Marcela (advisor)
The aim of my diploma project is to design a nearly-zero energy kindergarten. Building is located in Brno – Starý Lískovec. It´s a single-storey, detached building. It has 2 classes with bathrooms and locker rooms for 40 childrens . Other rooms are: headmaster´s office, kitchen, staff facilities and technical room. Load-bearing walls are made from masonry and non-load-bearing walls are from adobe blocks. Floor slab is made from reinforced concrete. There is a flat green roof with photovoltaic panels. The building is heated by heat pump and uses mechanical ventilation with heat recovery. As a third part of my project, I´m comparing three diferent heat sources. The criteria according to which the resources were assessed are the score from the energy performance of building certificate, the amount of emissions and the spatial complexity of the technologies.
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Notice in the French employment law compared with the employment law in the Czech republic
Jakubec, Martin ; Morávek, Jakub (advisor) ; Koldinská, Kristina (referee)
Abrégé Cette memoire a pour le but la présentation de la demission et le licenciement dans le droit du travail français et la comparaison de ceux-ci avec le droit du travail tchèque. La partie préliminaire présente en bref le code du travail français et explique aussi le statut du salarié et de l'employeur dans le droit français et mentionne des problèmes qui s'attachent à cette problématique. La partie préliminaire, qui parle du caractère élémentaire de la relation de travail est suivie par la seconde partie, la partie principale, qui disserte sur des conditions dans lesquelles la relation de travail peut être rompue dans le droit français et compare leurs différences avec le droit tchèque. A la fin l'auteur délibère sur ceux différences et leurs avantages et désavantages.
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Regulatory mechanisms of CD47 surface expression
Jakubec, Martin ; Drbal, Karel (advisor) ; Dibus, Michal (referee)
CD47 glycoprotein can be found on the surface of all healthy cells in our body. The interaction of CD47 with inhibitory receptor SIRPα on the macrophage leads to the inhibition of phagocytosis. This makes CD47 irreplaceable for the safe recognition of own cells and removal of aged or apoptotic cells. Apart from this, CD47 plays a major role in several essential signalling pathways, such as cell adhesion and motility or calcium homeostasis. The level of CD47 expression and its presence on the cell membrane depends not only on the type of tissue, but also on the age of a cell. An increased expression of CD47 protein has also been observed in the cells undergoing tumorigenic transformation, allowing them to escape from tumour immunosurveillance. Spontaneous regulation of the CD47 gene expression is achieved via regulatory transcription factors, such as NF-κB or HIF-1. Another mechanism of CD47 regulation includes the 3'UTR of CD47 mRNA, which serves as a binding site for either regulatory proteins, such as HuR, or miRNAs. CD47 expression can thus be regulated on both transcriptional, as well as translational level. However, appropriate topological CD47 localization within the cell and on the cell surface has also an important effect of its physiological function. Our in depth understanding of key regulatory...
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Apartment building
Jakubec, Marek ; Jelínková, Barbora (referee) ; Jelínek, Petr (advisor)
The task of this bachelor's thesis was to process the project documentation for the construction of an apartment building in the city of Brno. The apartment house is a free-standing, with three storeys and no basement. The building is covered with a flat roof. On the 1st floor there are 3 garage spaces, cellars and technical facilities of the building. There are a total of 4 housing units on the 2nd and 3rd floors. On the second and third floors, the structures recede and create terraces in two apartments. The other two apartments have their own balconies. Perimeter masonry is made of ceramic blocks with insulation. The ceiling structure is made of reinforced concrete. The bachelor thesis also contains an assessment of the building in terms of building physics and fire safety.
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