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Hereditary Mitochondrial Disorders Caused by Oxidative Phosphorylation Disfunction
Hanušová, Eva ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
Hereditary Mitochondrial Disorders Caused by Oxidative Phosphorylation Dysfunction This bachelor thesis deals with problems of hereditary mitochondrial disorders that are caused by various dysfunctions of proteins in oxidative fosforylation known as OXPHOS complex. Following recherche provides the reader with information about the genom and the structure of mitochondria where the OXPHOS is realized and about its structure and progress. I describe basic facts about various mutations in nuclear and mitochondrial DNA that negatively affect function of OXPHOS complex and the biogenesis of mitochondria. The focus of this work is to summarize the newest data of individual diseases - their clinical manifestation, etiopatogenesis, prevalance in population and its possible treatment and prevention. Key words: hereditary, mtDNA, mitochondrial diseases, OXPHOS complex
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Education of Molecular Biology at Secondary School and Analysis of Preconception of Nucleic Acids Term
Hanušová, Eva ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The theoretical part assembles methodological starting points for the research - the content and meaning of curricula documents for science education; the contemporary scientific knowledge about selected molecularly biological topics taught at secondary schools; the characteristics of student preconceptions and misconceptions, their diagnosis and importance. The practical part contains the setting of research problems and aims related to their object, presented as the content analysis of curriculum and the teaching methods concerning molecularly biological topics at a selected secondary school; the diagnosis of preconceptions regarding the term "nucleic acids" with pupils (first, third and fourth grade) studying at a selected secondary school (ninety- five respondents) that served to the determination of overall character of stated preconception (genesis, modification and conceptual change during the study at a secondary school). The incorporation of new laboratory exercises with the topic of nucleic acids to the education in the fourth grade and the assessment of their impact on the shape of the preconception has been also the part of the project. The evaluation was done by comparing of success in solving the tasks involved in the didactic test for pupils in the first and third grade and pupils...
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Hereditary Mitochondrial Disorders Caused by Oxidative Phosphorylation Disfunction
Hanušová, Eva ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
Hereditary Mitochondrial Disorders Caused by Oxidative Phosphorylation Dysfunction This bachelor thesis deals with problems of hereditary mitochondrial disorders that are caused by various dysfunctions of proteins in oxidative fosforylation known as OXPHOS complex. Following recherche provides the reader with information about the genom and the structure of mitochondria where the OXPHOS is realized and about its structure and progress. I describe basic facts about various mutations in nuclear and mitochondrial DNA that negatively affect function of OXPHOS complex and the biogenesis of mitochondria. The focus of this work is to summarize the newest data of individual diseases - their clinical manifestation, etiopatogenesis, prevalance in population and its possible treatment and prevention. Key words: hereditary, mtDNA, mitochondrial diseases, OXPHOS complex
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