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ANALÝZA PROSTOROVÉ MOBILITY OBYVATEL MĚSTA VODŇANY
HOMOLKA, David
The bachelor thesis deals with the daily spatial mobility of residents of the city of Vodňany in the district of Strakonice, in the South Bohemian Region. The theoretical part focuses on the analysis of professional literature on the topic of spatial mobility, transportation geography, time geography, and includes a characterization of the city. The practical part introduces the methodology of data collection, which was carried out through questionnaire surveys in individual households. This is followed by the evaluation of the research results and individual hypotheses using tables and graphs, which are compared with the results of previous research on similar topics both domestically and internationally. The main indicators for evaluating spatial mobility were the number of trips, distance, and time spent on travel. Based on the results, different patterns of spatial behavior between women and men were demonstrated, with women making more trips over shorter distances in smaller time intervals than men. The results also showed a clear preference for car usage over public transportation, with car usage not showing an increasing trend in the examined sample with higher incomes. In conclusion, all results and findings are summarized.
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Belt conveyor for food corn
Homolka, David ; Jonák, Martin (referee) ; Malášek, Jiří (advisor)
The aim of this thesis is to design an angled belt conveyor for transportation of food corn with the capacity of 65,000 kg per hour and axial distance between the drums at both ends of 20 meters and height difference of 6 meters. The thesis includes brief descriptions of individual parts of the conveyor, functional calculation, which is performed according to the current standard ISO 5048, determination of basic dimensions, design of the drive and tensioning device of the conveyor. In its nal part, the thesis contains an analysis of the characteristics of transported material. The thesis is accompanied by all the necessary technical drawings.
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Meiotic sex chromosome inactivation within mouse spermatogenesis
Homolka, David ; Jansa, Petr (advisor) ; Kubelka, Michal (referee) ; Pěknicová, Jana (referee)
Meiotic sex chromosome inactivation (MSCI) is an essential epigenetic process, which transcriptionally silences X and Y chromosomes during spermatogenesis. It is accompanied by substantial chromatin remodeling resulting in a formation of so called sex or XY body, which is a characteristic of male pachytene spermatocytes. In spite of MSCI indispensability for male fertility, its biological role and molecular nature still remain rather unclear. However, the described link between chromosomal asynapsis and transcriptional silencing demonstrated that MSCI is tightly associated with the asynapsis of largely non-homologous sex chromosomes and is a specific form of more general mechanism called meiotic silencing of unsynapsed chromatin (MSUC). The essential role of MSCI was demonstrated using mouse models, such as carriers of X- autosome translocations, where anomalous synapsis of sex chromosomes leads to impairment of MSCI and male sterility. Intriguingly, the exclusive spermatogenic arrest is a hallmark of not only X-autosome translocations but even various autosomal rearrangements, including autosomal translocations, inversions, or other structural mutations. Because the rearranged autosomes often intimately associate with the sex body, it...
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Belt conveyor for food corn
Homolka, David ; Jonák, Martin (referee) ; Malášek, Jiří (advisor)
The aim of this thesis is to design an angled belt conveyor for transportation of food corn with the capacity of 65,000 kg per hour and axial distance between the drums at both ends of 20 meters and height difference of 6 meters. The thesis includes brief descriptions of individual parts of the conveyor, functional calculation, which is performed according to the current standard ISO 5048, determination of basic dimensions, design of the drive and tensioning device of the conveyor. In its nal part, the thesis contains an analysis of the characteristics of transported material. The thesis is accompanied by all the necessary technical drawings.
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Meiotic sex chromosome inactivation within mouse spermatogenesis
Homolka, David ; Jansa, Petr (advisor) ; Kubelka, Michal (referee) ; Pěknicová, Jana (referee)
Meiotic sex chromosome inactivation (MSCI) is an essential epigenetic process, which transcriptionally silences X and Y chromosomes during spermatogenesis. It is accompanied by substantial chromatin remodeling resulting in a formation of so called sex or XY body, which is a characteristic of male pachytene spermatocytes. In spite of MSCI indispensability for male fertility, its biological role and molecular nature still remain rather unclear. However, the described link between chromosomal asynapsis and transcriptional silencing demonstrated that MSCI is tightly associated with the asynapsis of largely non-homologous sex chromosomes and is a specific form of more general mechanism called meiotic silencing of unsynapsed chromatin (MSUC). The essential role of MSCI was demonstrated using mouse models, such as carriers of X- autosome translocations, where anomalous synapsis of sex chromosomes leads to impairment of MSCI and male sterility. Intriguingly, the exclusive spermatogenic arrest is a hallmark of not only X-autosome translocations but even various autosomal rearrangements, including autosomal translocations, inversions, or other structural mutations. Because the rearranged autosomes often intimately associate with the sex body, it...
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Web application development in Node.js
Homolka, David ; Šimek, Pavel (advisor)
Thesis deals with development of Web Application in Node.js. Web solution represents visualization of many various meteorological data and fills it into maps of planet Earth. User can view any available data about world weather or he can upload own file with data. The complete application is created in JavaScript, which is used on client side and server side.
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Analýza samčí sterility způsobené T(16,17)43H chromosomální translokací
Čapková, Jana ; Homolka, David ; Ivánek, Robert ; Jansa, Petr ; Forejt, Jiří
Heterozygosity for certain mouse and human chromosomal rearrangements is characterized by male-limited sterility. Our model of a male-sterile chromosomal rearrangement represents mouse T(16;17)43H (T43) chromosomal translocation. The effect of the T43H translocation on spermatogenesis was studied. We analyzed meiosis in B10.T43/+ heterozygous male mice and we have obtained direct evidence on the transcriptional silencing of unsynapsed autosomal chromatin of the translocation quadrivalent and the subsequent failure of the X chromosome transcriptional inactivation at the mid-late pachytene of spermatogenesis.
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