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Analysis of drug administration by nurses in health facility XI
Altmannová, Tereza ; Doseděl, Martin (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XI Author: Tereza Altmannová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are intrinsically linked to the practice of the medical profession. They can occur at several levels - prescription, drug preparation, dispensation, administration, and subsequent use of the drug by the patient. Nurses play an important role in the process of the drug administration in a hospital setting. Because of the occurrenceof medication errors and the consequent inability to achieve desired health outcomes, efforts are nowadays made to detect and minimize them. The aim of this study was to detect and analyze medication errors occurring during drug administration by nurses in a healthcare facility in South Bohemia. Methodology: The study is a part of a multi-year project involving the Faculty of Pharmacy of Charles University. The methodology is based on an observational study. The data collection took place in April 2022. Three hospital wards were assigned for the observation, where morning, midday and evening drug administration was monitored for three consecutive days. Data were recorded on a pre- generated form based on the...
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Drug utilization of specific biotherapeutic agents and biosimilars in the Czech Republic
Vasko, Olha ; Dvořáčková, Simona (advisor) ; Babica, Jan (referee)
Drug utilization of specific biotherapeutic agents and biosimilars in the Czech Republic Author: Olha Vasko Supervisor: PharmDr. Simona Dvořáčková, Ph.D. Department of Social and Clinical Pharmacy Faculty of Pharmacy in Hradec Králové, Charles University in Prague Introduction: Biosimilars represent an alternative to innovative biological medicinal products, contribute to improvement of the effectiveness of treatment and enable to gain access to expensive therapy of serious diseases. Objective: The objective of the practical part of the diploma thesis was to analyze trends in drug utilization of specific biotherapeutic agents and biosimilars in the Czech Republic between 2008-2022. The secondary aim of the practical part was analysis of the expenditures for specific biotherapeutic agents and biosimilars in given period. Methods: Drug utilization from the database of the State Institute for Drug Control has been evaluated from 2008 until 2022. The values of defined daily doses were used to process the results, which were subsequently converted to the number of defined daily doses per 1000 inhabitants per day (DID). Descriptive statistics was used for the retrospective analysis of the drug utilization. The following drugs were included in the analysis: filgrastim, pegfilgrastim, lipegfilgrastim,...
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Analysis of drug administration by nurses in health facility XV.
Chudovská, Denisa ; Malý, Josef (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XV. Author: Denisa Chudovská Tutor: doc. PharmDr. Josef Malý. Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: The role of nurses is key not only in the occurrence of medication errors, but also in their prevention. The aim of the thesis was to analyze the administration of medications by nurses to patients hospitalized in three departments within a healthcare facility and to compare the results with the first year of monitoring in the given hospital. Methods: This is an observational-interventional study. The data collection method was passive observation. The study included patients in surgical, internal medicine, and post-care departments within one of the four hospitals in the Czech Republic. Data collection took place over three consecutive days. The collected data encompassed information: about the patient, the nurse and medication name, strength, preparation, administration, usage verification. The analysis of obtained data was performed using a Summary of Product Characteristics and relevant information sources available at the Pharmaceutical Faculty of Charles University in Hradec Králové. To assess the impact of...
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Oral Contraceptive Consumption in the Czech Republic
Zahradniková, Barbara ; Ťupová, Lenka (advisor) ; Dvořáčková, Simona (referee)
Title: Oral Contraceptive Consumption in the Czech Republic Author: Barbara Zahradniková, DiS. Supervisor: PharmDr. Lenka Ťupová, Ph.D. Introduction: Hormonal contraception is a group of drugs used to prevent pregnancy. In addition, it is also used in the number of other indications, such as reducing the manifestations of acne vulgaris, reducing heavy menstrual bleeding, regulating the menstrual cycle or relieving premenstrual symptoms. Objective: The aim of the diploma thesis was to analyse and evaluate the consumption of all types of hormonal contraception in the Czech Republic in the period from 2008 to 2022 using data obtained from the database of the State Institute for Drug Control (SIDC). Methods: A retrospective consumption analysis was used for the evaluation. Consumption was evaluated based on the number of packages delivered to healthcare facilities in the period between 2008-2022. The obtained data were classified according to individual ATC codes and then compared according to established parameters, e.g. type of evaluated hormonal contraception or dosage form. Results: During the monitored period, the consumption of combined contraception clearly dominated (89,62 %) over the progestagen type of contraception (10,38 %). In the case of combined hormonal contraception, the largest part...
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Analysis of drug administration by nurses in health facility XI
Altmannová, Tereza ; Doseděl, Martin (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XI Author: Tereza Altmannová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are intrinsically linked to the practice of the medical profession. They can occur at several levels - prescription, drug preparation, dispensation, administration, and subsequent use of the drug by the patient. Nurses play an important role in the process of the drug administration in a hospital setting. Because of the occurrenceof medication errors and the consequent inability to achieve desired health outcomes, efforts are nowadays made to detect and minimize them. The aim of this study was to detect and analyze medication errors occurring during drug administration by nurses in a healthcare facility in South Bohemia. Methodology: The study is a part of a multi-year project involving the Faculty of Pharmacy of Charles University. The methodology is based on an observational study. The data collection took place in April 2022. Three hospital wards were assigned for the observation, where morning, midday and evening drug administration was monitored for three consecutive days. Data were recorded on a pre- generated form based on the...
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The aspects influencing the therapeutic value of anticoagulants in the Czech Republic
Dvořáčková, Simona ; Kolář, Jozef (advisor) ; Trejtnar, František (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Social and Clinical Pharmacy Doctoral Degree Program Clinical and Social Pharmacy Candidate Mgr. Simona Dvořáčková Supervisor doc. RNDr. Jozef Kolář, CSc. Advisor doc. PharmDr. Josef Malý, Ph.D. Title of Doctoral Thesis The aspects influencing the therapeutic value of anticoagulants in the Czech Republic Background and aim: Anticoagulants prevent the onset or maintaining of thromboembolic (TE) diseases. Both long-term used drugs, the disadvantages of which may limit treatment, and newer ones, the benefits of which may be limited by shorter clinical experience, are currently approved. Drug utilization may be an important indicator of trends in drug use, as well as pharmacovigilance surveillance and the benefits and risks assessment in clinical practice. Research related to the evaluation of the therapeutic value of anticoagulants and the factors influencing their use in clinical practice contribute to safer pharmacotherapy, therefore the aims of this thesis were: 1) to analyze the drug utilization of parenteral and oral anticoagulants (OACs) in the Czech Republic (CR) between the years 2007-2020; 2) to evaluate the numbers and characteristics of spontaneously reported suspected adverse drug reactions (ADRs)...
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Fractal aspects of sodium chloride flow.
Dvořáčková, Simona ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdeňka Šklubalová, PhD. Student: Simona Dvořáčková Title of Thesis: Fractal aspects of sodium chloride flow The flowability of substances is affected by their granulometric characteristics, such as the size and the shape. In this thesis, the relations between particle size and flow rate of the sodium chloride size fractions in a range of 80-630 µm through the circular outlet of the conical stainless hopper in a range of 6-15 mm are studied. The Jones & Pilpel power equation was used to model the dependence. A linear relationship between the exponent of the Jones & Pilpel power equation and the mean size of particles was noted. The fractal aspects of flow rate (the mass and/or the volume ones) were investigated using the results of the optical microscopy. A nonlinear dependence between the flow rate and the mean particle size and/or the particle perimeter was detected.
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The aspects influencing the therapeutic value of anticoagulants in the Czech Republic
Dvořáčková, Simona ; Kolář, Jozef (advisor) ; Trejtnar, František (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Social and Clinical Pharmacy Doctoral Degree Program Clinical and Social Pharmacy Candidate Mgr. Simona Dvořáčková Supervisor doc. RNDr. Jozef Kolář, CSc. Advisor doc. PharmDr. Josef Malý, Ph.D. Title of Doctoral Thesis The aspects influencing the therapeutic value of anticoagulants in the Czech Republic Background and aim: Anticoagulants prevent the onset or maintaining of thromboembolic (TE) diseases. Both long-term used drugs, the disadvantages of which may limit treatment, and newer ones, the benefits of which may be limited by shorter clinical experience, are currently approved. Drug utilization may be an important indicator of trends in drug use, as well as pharmacovigilance surveillance and the benefits and risks assessment in clinical practice. Research related to the evaluation of the therapeutic value of anticoagulants and the factors influencing their use in clinical practice contribute to safer pharmacotherapy, therefore the aims of this thesis were: 1) to analyze the drug utilization of parenteral and oral anticoagulants (OACs) in the Czech Republic (CR) between the years 2007-2020; 2) to evaluate the numbers and characteristics of spontaneously reported suspected adverse drug reactions (ADRs)...
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Fractal aspects of sodium chloride flow.
Dvořáčková, Simona ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdeňka Šklubalová, PhD. Student: Simona Dvořáčková Title of Thesis: Fractal aspects of sodium chloride flow The flowability of substances is affected by their granulometric characteristics, such as the size and the shape. In this thesis, the relations between particle size and flow rate of the sodium chloride size fractions in a range of 80-630 µm through the circular outlet of the conical stainless hopper in a range of 6-15 mm are studied. The Jones & Pilpel power equation was used to model the dependence. A linear relationship between the exponent of the Jones & Pilpel power equation and the mean size of particles was noted. The fractal aspects of flow rate (the mass and/or the volume ones) were investigated using the results of the optical microscopy. A nonlinear dependence between the flow rate and the mean particle size and/or the particle perimeter was detected.
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