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Effect of helminthosis on host's biotransformation enzymes
Bártíková, Hana ; Szotáková, Barbora (advisor) ; Lamka, Jiří (referee)
(EN) Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Hana Bártíková Consultant: Doc. Ing. Barbora Szotáková, Ph.D. Title: The effect of parasitosis on the host's biotransformation enzymes Parasitic diseases cause significant economic losses in livestock, domestic and wild animals. World-wide spread species Haemonchus contortus parasiting in gastrointestinal tract of ruminants exhibits relatively high degree of pathogenity. To treat haemonchosis the benzimidazole anthelmintics are used. Altered activity of the enzymes participating in biotransformation of these drugs can affect the treatment. The induction of host's enzymes can contribute to the resistance of the worms to the available anthelmintics. This project studies influence of haemonchosis to the activity of sheep's biotransformation enzymes. Oxidative, conjugation and reductive enzymes have been studied both in healthy and sick sheep. Cytosolic and microsomal fractions of liver and small intestine have been used for determination of enzymatic activities. In the most of monitored oxidative enzymes the inhibition of activity has been observed. On the contrary, parasitosis has caused enzymatic induction of conjugation enzymes. The results in group of reductive enzymes don't offer...
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Biotransformation and Transport of Xenobiotics in Helminths
Bártíková, Hana ; Szotáková, Barbora (advisor) ; Horák, Petr (referee) ; Machala, Miroslav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Biochemical Sciences Candidate Mgr. Hana Bártíková Supervisor Doc. Ing. Barbora Szotáková, Ph.D. Title of Doctoral Thesis Biotransformation and transport of xenobiotics in helminths Infectious diseases caused by parasitic helminths are a major problem threatening health of domestic and wild animals and affecting agricultural industry worldwide. Treatment of helminthoses is based on administration of anthelmintic drugs, with benzimidazoles being the most important group. Unfortunately, the irrational use of similar anthelmintics has led to the development of drug resistance in helminths, thus causing a serious problem in the veterinary practice. Possible mechanisms of drug resistance development include changes of pharmacokinetic processes (changes in drug transport or increased drug deactivation), which are based on an increased activity of biotransformation enzymes and transporters in helminths. Understanding the mechanisms of drug resistance and defence strategies of parasites against drugs can prolong the efficacy of current anthelmintics and help to find new strategies for the control of helminthoses. Although drug metabolizing enzymes and transporters of helminths serve as an efficient defence...
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Effect of helminthosis on host's biotransformation enzymes
Bártíková, Hana ; Szotáková, Barbora (advisor) ; Lamka, Jiří (referee)
(EN) Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Hana Bártíková Consultant: Doc. Ing. Barbora Szotáková, Ph.D. Title: The effect of parasitosis on the host's biotransformation enzymes Parasitic diseases cause significant economic losses in livestock, domestic and wild animals. World-wide spread species Haemonchus contortus parasiting in gastrointestinal tract of ruminants exhibits relatively high degree of pathogenity. To treat haemonchosis the benzimidazole anthelmintics are used. Altered activity of the enzymes participating in biotransformation of these drugs can affect the treatment. The induction of host's enzymes can contribute to the resistance of the worms to the available anthelmintics. This project studies influence of haemonchosis to the activity of sheep's biotransformation enzymes. Oxidative, conjugation and reductive enzymes have been studied both in healthy and sick sheep. Cytosolic and microsomal fractions of liver and small intestine have been used for determination of enzymatic activities. In the most of monitored oxidative enzymes the inhibition of activity has been observed. On the contrary, parasitosis has caused enzymatic induction of conjugation enzymes. The results in group of reductive enzymes don't offer...
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Quality of Life of Patients with hemo and peritoneal dialysis
Valová, Radka ; Lešetický, Ondřej (advisor) ; Bártíková, Hana (referee)
A patient has two possibilities when it comes to the replacement of a function of kidneys a hemodialysis or a peritoneal dialysis. The aim of those dialysis is to remove the waste matter, water and redundant salts, which are maintained in the blood due to the dysfunction of kidneys. This thesis is focused on the evaluation of the quality of life of patients with hemodialysis and peritoneal dialysis. The thesis is divided into two parts -- a theoretical and a practical one. In the first part you can find the characteristics and the main principle of the hemodialysis and peritoneal dialysis and there is also a definition of a term the quality of life. The second part is based on a questionnaire survey dedicated to the personal perception of the quality of life of the patients with hemodialysis and peritoneal dialysis in Jindřichův Hradec and Tábor.
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Utilisation of financial resources for promotion a company
BÁRTÍKOVÁ, Hana
The aim of this thesis is the evaluation of using financial resources for promotion of a company and to propose their appropriate changes. I have chosen company ČZ a.s. with production plant in Strakonice. This company is one of the biggest engineering companies in South Bohemia and even in the Czech Republic. Thesis is pointed to evaluation of the means of promotion. Top management of ČZ company give it to me all necessary informations to perform analysis.
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Introduction of the product on the market
BÁRTÍKOVÁ, Hana
This thesis deals with the valorizing contemporary strategy of the launch of product on the market and to propose right method of solution. I have chosen company ČZ a.s. with production plant in Strakonice. This company is one of the biggest engineering companies in the Czech Republic. Thesis is pointed to introduces to forklift truck D 50 on the market. Top management of ČZ company give it to me all necessary informations to perform analysis.
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Labour force migration in Plzeň region
Bártíková, Hana ; Kotýnková, Magdalena (advisor) ; Gráf, Václav (referee)
This thesis called "Labour force migration in Plzeň region" is focused on employing foreigners in labour market, particularly at regional level. The thesis contains description of theories applied on situation in the Czech Republic, as well as development of Czech immigration policy since 1989. Furthermore, the thesis describes forms of employment of foreigners in the Czech labour market, with special emphasis on the description of forms which are considered to be irregular. It analyzes these irregular forms of employment in the Czech context, focusing on the most significant minority in our country. It describes the economic consequences of these phenomena. The overall assessment of the situation is supported by a framework calculation.
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