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Effect of Surgical Cerebral Revascularization on Hemodynamics, Clinic and Neurocognitive Performance
Košťál, Petr ; Přibáň, Vladimír (advisor) ; Grus, Tomáš (referee) ; Šámal, Filip (referee)
4 Abstract Introduction Since 2016, we know that the neuron responds to chronic hypoperfusion by reducing its performance. Cerebral revascularization using extra-intracranial bypass in internal carotid occlusion has also been shown to improve this reduction in function. In the case of asymptomatic internal carotid stenosis (ACS), hypoperfusion of the brain may occur due to insufficient collateralization. It is not clear whether this condition can lead to changes in cognitive performance. Likewise, the impact of hemodynamic changes on cognition in patients with ACS after carotid endarterectomy (CEA) remains unclear. The aim of this study was to evaluate the results of CEA for ACS at one year by assessing the changes in anterior, middle, and posterior cerebral artery blood flow in tandem with changes in cognitive efficiency. Methodology As part of the prospective study, the flow volume in cerebral arteries using quantitative magnetic resonance angiography was measured in a group of 14 males and 5 females before and at one year after CEA for ACS. Cognitive efficiency was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The values of flow volume were processed using simple ratio (SR) and were used for analyses with changes in cognitive skills after CEA. Results One year...
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název v anglickém jazyce není uveden
Šámal, Filip ; Haninec, Pavel (advisor) ; Vyklický, Ladislav (referee) ; Zvěřina, Eduard (referee)
Traumatic injury of peripheral nerves represents an important area of present-day clinical and experimental interest. Despite a large quantity of experimental data acquired in an intense research of this topic carried out in recent years, traumatic affection of peripheral nerves continues to be a complex surgical problem. Injury of peripheral nerves often results in a permanent and serious impairment in the patients' lives connected with the loss of the affected peripheral nerve function. If an injured nerve is given a timely and correct treatment, these consequences can be prevented to a certain extent. In the current practice this implies the use of all available methods of peripheral nerves surgery, primarily microsurgical operation technique while observing some of the basic principles essential for a good functional reinervation. This mainly applies to tension-free suture. In some anatomic locations and despite observing the above-mentioned facts, it is still difficult to reach good functional results. This primarily applies to brachial plexus injury which is one of the most complicated and serious of all lesions of peripheral nerves. Out of the total number of nerve injuries they are represented in large sets by three to seven percent. In his set, Midha reports 1.2% of patients affected by the...
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