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Multifunctional building Litomyšl
Kovář, Lukáš ; Utíkal, Aleš (referee) ; Utíkalová, Ivana (advisor)
Diploma thesis deals with the design of the multifunctional building located between Havlickova and F. Vogner streets in relation to the existing building in Litomyšl. Building plot is slightly sloping, at the rear goes into greater inclination. The building has four aboveground floors and one underground floor. The building includes services, located in ground floor, administrative premises decomposing in the second and third floor and apartments on the top floor. In the basement are located parking spaces. Supporting skeleton of the building is a cast-in-place concrete frame. Roofs are designed as a flat single shell. In part of roof over third floor is a green roof. The building is founded on piles. Due to the occurrence of water pressure is building an extra solved waterproofing system with checks and activation. The work includes text messages, drawings for building construction, fire safety design, construction and physical assessment of building structures and specialization from concrete structures.
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Model e-advertising Segment of the Selected e-commerce
Smrž, Marek ; Kovář, Libor (referee) ; Dvořák, Jiří (advisor)
Master’s thesis describes plus evaluates small firm that the deal with production plus sale ceramic performances. Work is divided on several part, in which survey especially on analysis e - commerce that the firm employs plus on his inadequacies, largely in the area e- advertising. Feature plus scope of employment is suggest mock - up e- advertising, that shall in connection with his costs viable.
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Locomotive engines ČKD
Kovář, Lukáš ; Janoušek, Michal (referee) ; Zubík, Martin (advisor)
The work contains summary of locomotive diesel engines ČKD and description of the basic specification of these engines and its comparison with modern engines from selected manufacturers. This work also focuses on specific conditions of engines used in rail vehicles.
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Detached house with a patisserie
Kovář, Lukáš ; Rybaková, Anna (referee) ; Utíkalová, Ivana (advisor)
This bachelor thesis deals with the design of the house with a patisserie located in Litomyšl. It is a two storey detached building. The building has a rugged floor plan consists of three rectangles, which are irregularly superimposed over each other. The building is covered gable roof over the living area and two flat roofs over the operation of pastry shops and garages. On the first floor is composed of operation patisserie shop with seating (including a separate barrier-free WC for women and men), kitchen, warehouse and production facilities for employees (WC, shower and dressing room). In another wing of the building adjacent to the ice cream parlor are located residential portion of the house (kitchen, living room and office) with a technical background (utility room and WC) and a corridor from which enters via a staircase to the second storey. In this part of the building is a hall with study, living rooms (two children's rooms and bedroom), room of homework and bathroom. In the last wing is a double garage, which follows the house through a vestibule. The shop is part of the operation pergola covered terrace and parking areas. The work includes text messages, drawings for building construction, fire safety design, construction and physical assessment of building structures and seminar work of wooden facade cladding.
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Glykosylace povrchové membrány EL-4 buněk: vliv volného nebo N-(2-hydroxypropyl)methacrylamide (HPMA) vázaného doxorubicinu
Kovář, Lubomír ; Etrych, Tomáš ; Šubr, Vladimír ; Strohalm, Jiří ; Sklenář, Jan ; Chytil, Petr ; Ulbrich, Karel ; Říhová, Blanka
In those experimenst we studied the possible impace of CD43 as highly glycosylated molecule in cells exposed to free doxorubicin (Dox) or to conjugates consisting of HPMA copolymer backbone to which the drug is conjugated via enzymatically (PK1 conjugate) or pH sensitive, hydrolytically cleavable bond (hydrazone conjugate, HYD).
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