Original title: Surface membrane glycosylation of EL-4 cells: the impact of free or N-(2-hydroxypropyl)methacrylamide (HPMA) bound doxorubicin
Translated title: Glykosylace povrchové membrány EL-4 buněk: vliv volného nebo N-(2-hydroxypropyl)methacrylamide (HPMA) vázaného doxorubicinu
Authors: Kovář, Lubomír ; Etrych, Tomáš ; Šubr, Vladimír ; Strohalm, Jiří ; Sklenář, Jan ; Chytil, Petr ; Ulbrich, Karel ; Říhová, Blanka
Document type: Papers
Conference/Event: International Workshop on Drug Delivery Systems /5./, Třeštˇ (CZ), 2007-05-15 / 2007-5-18
Year: 2007
Language: eng
Abstract: [eng] [cze]
In those experimenst we studied the possible impace of CD43 as highly glycosylated molecule in cells exposed to free doxorubicin (Dox) or to conjugates consisting of HPMA copolymer backbone to which the drug is conjugated via enzymatically (PK1 conjugate) or pH sensitive, hydrolytically cleavable bond (hydrazone conjugate, HYD). V těchto pokusech jsme sledovali vliv vysoce glykosylované povrchové molekuly CD43 u buněk vystaveným volnému doxorubicinu nebo doxorubicinu konjugovanému k HPMA polymeru
Keywords: doxorubicin
Project no.: CEZ:AV0Z50200510 (CEP), CEZ:AV0Z40500505 (CEP), GA305/05/2268 (CEP)
Funding provider: GA ČR
Host item entry: International Workshop on Drug Delivery Systems /5./

Institution: Institute of Microbiology AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0158196

Permalink: http://www.nusl.cz/ntk/nusl-38485


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Research > Institutes ASCR > Institute of Microbiology
Conference materials > Papers