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Cardiopulmonary resuscitation - equipment (recommendations, instruments)
Fialová, Kateřina ; Kupečková, Ivana (advisor) ; Klicperová, Zuzana (referee) ; Mathauser, Radek (referee)
In the theory part I was dealing with history of resuscitation from the prehistory to Guidelines 2000 and with the recomended procedure in resuscitation guidelines 2005.After that I wrote up the equipment which is used for the advanced cardiopulmonary resuscitation. In the last part I was taking a think about legislativity which is conected with providing the laic and advanced cardiopulmonary resuscitation. The second, empiric part is researching the whole equipment (facilitations, gear and drugs), for cardiopulmonary resuscitation in the regional hospital in Náchod and participation of standards for inspection and usage of this equipment for resuscitation. The questionary action was proceeding from 4.12.2007 to 10.1.2008 in regional hospital in Náchod, a. s. by method of personal investigation. I used the questionaires results for creating two standards. I created standard "Default facilitations, gear and drugs in regional hospital in Náchod a. s." and "Methodics of providing cardiopulmonary resuscitation in regional hospital in Náchod a. s".
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Cutting ceramics and its effective use
Fialová, Kateřina ; Prokop, Jaroslav (referee) ; Humár, Anton (advisor)
The diploma work is focused on the ceramic tool materials and its effective use. The introductory part of the work contains the detail characteristic of the ceramic tool materials from the point of view of their dividing, physic-mechanical propertis, production methods and marking. The main part of the work is focused to judging of the ceramic portion at the production assortment of the top World producers of tool materials and to evaluation of cutting ability of the particular materials of these producers. The detail analysis of recommended cutting conditions, which is aimed to an effective use of the ceramic materials, had been worked up for this purpose. The technical economic analysis confirms, that the present effective aplications of ceramic are limited only for specific cases of machining cast irons, steels and alloys.
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Leiden mutation, its signification and methods of examination
FIALOVÁ, Kateřina
The subject of this thesis is Leiden mutation, its signification and methods of examination. This work deals with frequency of occurrence F V Leiden mutation in samples of examinants in the centre of laboratory medicine BioLab, spol. s. r. o., in Klatovy. Thrombophilia (hypercoagulation) is a genetic or acquired failure of hemostatic mechanistic system, which is connected with increased risk of the occurrence of thrombosis. The most important and the most frequent effect of thrombophilia is the venous thromboembolism. This concept means both deep venous thrombosis and/or pulmonary embolism and their development is always caused by several factors which are genetic or acquired. Mutation of factor V was described in 1993 as the resistance against activated protein (so called APC-resistance). It occurs most commonly as a genetic thrombophilia of white race where it can be found in 40% of patients with diagnosed thromboembolism. Leiden mutation in a gene for factor V is the most frequent predisposition for thrombosis. The risk of development of venous thromboembolism differs according as the fact if it is a heterozygotic or homozygotic carrier. Heterozygotic individuals are 7 times more riskly as for the development of venous thrombosis while the risk level in homozygotic individuals is 80 times. The rate of prevalence of FV Leiden mutation in the world ranges from 0 to 15 %. APC- resistance is caused by point mutation in the polynucleotide chain of a gene for factor V. Here it concerns the exchange of the nucleotide sequence respectively nitrogen basis of guanine and adenine for the position 1691 (G1691A). It creates a triplet which codes in position 506 in the place of amino acid arginine -Arg, R, glutamine -Gln, Q(R506Q). It causes resistance of the active factor V against protein C, which is to inactivate it. The factor V stays henceforth pro- coagulative and thus the creation of thrombin increases together with the risk of thromboembolic disease. The goal of this thesis was summarising of research findings related to the focused theme Leiden mutation, its signification and methods of examination, analyze whole blood samples of patients examined at Leiden mutation carrier status in the center of Laboratory Medicine BioLab, spol. s. r. o. in Klatovy and in consequence and then evaluate and interpret the results of the found out results. Carrier of FV Leiden mutation was observed in a group of patients of both sexes coming from Plzeň and Ústí nad Labem region using real-time PCR. Of the 169 patients examined 111 samples were obtained from women and 58 samples from men. Among women there were found 21 heterozygous carriers (18.9%) and 1 homozygous carrier of (0.9%) FV Leiden mutation. The male population was observed incidence of 17 heterozygotes (29.3%). None of the men did not hold the homozygous genotype FV Leiden mutation. Although the men were twice as frequent carriers of that mutation was not statistical analyzes demonstrated the effect of gender on the transfer FV Leiden mutation (P = 0.2).
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