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How the czech music magazines contributed to the process of comercionalization of electronic dance music?
Vacek, Vojtěch ; Hroch, Miloš (advisor) ; Groman, Martin (referee)
This diploma thesis deals with the role of a printed music media in the process of commercialization of electronic dance music in the Czech Republic in the early 2000s. The research is based on the theoretical approach of subcultural studies, more specifically on the Chicago school. The theoretical part is focused on the definition of terms such as subculture, moral panic, subcultural capital and commercialization. The empirical part is focused on qualitative research of selected media, consisting of content analysis of contemporary periodicals and semi-structured interviews with selected media editors. In total, 134 issues were analyzed and four interviews were conducted with respondents as part of the research. The results show the role of selected magazines as subcultural media, which significantly contributed to the development of electronic dance music in our country. Using the obtained results, the work defines the main events and meanings by which the selected media influenced the dance music scene of that time. 1
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Punk's not dad - A radio documentary concerning the transmutation of life values of members of the punk subculturer
Trajerová, Magdalena ; Gulda, Jana (advisor) ; Hroch, Miloš (referee)
This practical work Punk's not dad - A radio documentary concerning the transmutation of life values of members of the punk subculture regarding the upbringing of children, as the name suggests, is dedicated to the change in the life values of punk subculture members due to raising children. Based on interviews with five protagonists and reportage footage from the punk environment, it answers the question of how punks work with values such as rejection of the future, resistance to the system or, for example, denial of authorities, in raising their children. The theoretical part of the thesis describes the specifics of radio production. Furthermore, the work contains definitions of basic radio genres with emphasis on the radio documentary, which is the main outcome of my work. The next section looks at punk and how this movement can affect a young person. In the last part I present my work. I deal with the aim of the document, the selection of the main protagonists, the script, the job description and the chosen methodology.
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Liberal vs. radical: which of the feminisms represents Heroine Magazine ?
Petřáková, Mariana ; Hroch, Miloš (advisor) ; Fousek Krobová, Tereza (referee)
The present bachelor thesis examines the content of the print version of Heroine magazine and analyses it in terms of contemporary feminist paradigms. The thesis examines the historical context of the feminist movement in the form of the traditional wave division, which has also produced two significant feminist currents, namely liberal and radical. The theoretical part is devoted to a thorough description of the historical events behind the formation of these currents, introducing their main authors, theoretical concepts and demands. It then places the relationship between feminism and the media in this context, with an emphasis on comparing the different developments of this relationship in the domestic and foreign media scene. The thesis also critically reflects on the rise of neoliberalism and sees it as an important variable in the context of the impact of the capitalist market on feminist media. The research part of this thesis combines in-depth interviews and qualitative text analysis to identify what themes Heroine magazine produces and how these themes reflect the state of contemporary feminist discourse.
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Open-source Intelligence in the Czech Media Landscape
Bartoš, Vojtěch ; Hroch, Miloš (advisor) ; Miessler, Jan (referee)
This thesis maps out the use of open-source intelligence in the Czech media landscape. Given the interdisciplinary nature of the field, a broad theoretical foundation introducing concepts such as Web 2.0, participatory culture, alternative media or the open-source movement is presented. Furthermore, the theoretical part of the thesis includes a classification of basic open-source intelligence techniques and raises an example of an organisation producing open-source intelligence reports. The empirical part of this thesis utilised a mixed approach of both qualitative and quantitative research methods. First, a quantitative analysis of Twitter posts categorised as written in Czech mentioning the keyword 'osint' published from May 2014 to March 2022 was realised. Results indicate a growth in the topic's popularity in Czech internet discourse and suggest a causality between the 2022 Russian invasion of Ukraine and a rising interest in open-source intelligence techniques. The qualitative part of the research makes use of semi-structured in-depth interviews conducted with 5 prominent Czech media actors using open-source intelligence in their media production process. The gathered data was subsequently analysed using the grounded theory. The results provide a comprehensive list of Czech-specific sources...
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City and dance culturer: prague rave scene - a series of interviews
Patočková, Tereza ; Hroch, Miloš (advisor) ; Lovaš, Karol (referee)
Practical bachelor thesis - City and dance culture: Prague rave scene - a series of journalistic interviews, documents the relationship between the segment of Prague dance culture - rave scene and the city, as a physical space that provides a refuge. The work seeks ways to ensure the sustainability of an important part of the scene - rave open air events, so-called warehouse parties. It is these events that are the most vulnerable part of the dance culture, as they depend on open urban locations, which are declining due to advancing gentrification. However, warehouse events are also threatened by the stance of city authorities, which in many cases decide whether or not to lend urban space to these events. The intention of this work is fulfilled by documenting the statements of the respondents, who were selected for the series on the basis of their relationship to the topic. The interviews mediate different perspectives on the topic of urban space and dance culture, which in turn provide a comprehensive picture of the possibilities that could lead to greater sustainability and stability of the scene in all its complexity. The theoretical part of the work approaches the historical context of rave culture and at the same time places it in the current framework of society and city life.
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The language of internernet media focused on skateboarding
Hroch, Miloš ; Šoltys, Otakar (advisor) ; Karaščáková, Zuzana (referee)
The aim of this study is to analyse language of internet media focused on skateboarding. An essential element of the introduction is a brief history of skateboarding globaly and here in the Czech Republic. The basis for the analysis of contemporary audiovisual clips also touches on the development of the distribution of skateboard videos. In this study I also mention the role of YouTube as a distributing tool and phenomenom of instant fame, which is not strong only in skateboarding, but it is a phenomenon across the full spectrum of society. The principal basis of this study is the definition of two print and later Internet traditions in skateboard journalism - Thrasher and Transworld Skateboarding magazine. The study also concerns itself with maping out the Czech media environment, where skateboarding has its own place. The genesis of skateboard media in the Czech Republic follows the formation of Thrasher and Transworld, which is a very interesting fact that is important for the general understanding of the topic. For deeper insight into skateboard subculture, I also mention the journalistic style of Czech skateboarding media. The Internet media has a special emphasis on visual content, more so than print media, due to traditional text being replaced by moving pictures, and therefore with help of...
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Analytical and bioanalytical evaluation of novel potential drugs from the group of iron chelators
Bureš, Jan ; Štěrbová, Petra (advisor) ; Kujovská Krčmová, Lenka (referee) ; Hroch, Miloš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Mgr. Jan Bureš Supervisor: Doc. PharmDr. Petra Štěrbová, Ph.D. Title of Thesis: Analytical and bioanalytical evaluation of novel potential drugs from the group of iron chelators High performance liquid chromatography (HPLC) gained its unprecedented position among bioanalytical techniques due to its effectivity and versatility. If tuned properly, it can separate complex mixtures and can be used for qualitative and quantitative analysis simultaneously, usually within a short time. Reliability of the HPLC methods is proven by their validation performed according to accepted guidelines. Iron chelation is considered to be an effective concept of treatment of various pathologies - from iron overload disease to cancer or neurodegenerative disorders. To develop new chelators for these indications it is important to investigate their structure- activity relationship, the fate of the drug in organism and its relationship to biological effects and toxicity etc. Modern analytical methods are essential tools for these studies. The first part of this work presents validated LC-UV and LC-MS methods for assay of aroylhydrazone iron chelators and related pro-drugs in biological...
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Determination of oxidative stress biomarkers by HPLC
Váňová, Nela ; Jun, Daniel (advisor) ; Doležal, Rafael (referee) ; Hroch, Miloš (referee)
and keywords Although reactive oxygen and nitrogen species have a fundamental role in physiological processes occurring in living organisms, their overproduction induced by endogenous and/or exogenous sources may lead to serious imbalance in redox homeostasis, damage to intracellular components and thus, dramatically alter their function or even trigger cell death. Oxidative stress is believed to be very important mechanism of toxicity of xenobiotics, including drugs, and may be responsible for the development of their unwanted side effects. Considering a very low number of studies evaluating oxidative stress after the treatment with oxime reactivators of acetylcholinesterase (AChE) in vivo and in vitro, the relationship between their toxicity and generation of specific biomarkers of oxidative damage is not still fully understood. In order to monitor antioxidant/prooxidant properties of drugs, high performance liquid chromatography method coupled with tandem mass spectrometry (LC-MS/MS) for simultaneous determination of two biomarkers of oxidative stress, malondialdehyde (MDA) and 3-nitrotyrosine (3-NT), in biological matrices was developed. Validation of this LC-MS/MS method demonstrated the acceptable appreciable selectivity, accuracy, intra- and interday precission, and recovery of sample...
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Analytical and bioanalytical evaluation of novel potential drugs from the group of iron chelators
Bureš, Jan ; Štěrbová, Petra (advisor) ; Kujovská Krčmová, Lenka (referee) ; Hroch, Miloš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Mgr. Jan Bureš Supervisor: Doc. PharmDr. Petra Štěrbová, Ph.D. Title of Thesis: Analytical and bioanalytical evaluation of novel potential drugs from the group of iron chelators High performance liquid chromatography (HPLC) gained its unprecedented position among bioanalytical techniques due to its effectivity and versatility. If tuned properly, it can separate complex mixtures and can be used for qualitative and quantitative analysis simultaneously, usually within a short time. Reliability of the HPLC methods is proven by their validation performed according to accepted guidelines. Iron chelation is considered to be an effective concept of treatment of various pathologies - from iron overload disease to cancer or neurodegenerative disorders. To develop new chelators for these indications it is important to investigate their structure- activity relationship, the fate of the drug in organism and its relationship to biological effects and toxicity etc. Modern analytical methods are essential tools for these studies. The first part of this work presents validated LC-UV and LC-MS methods for assay of aroylhydrazone iron chelators and related pro-drugs in biological...
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Development and Validation of HPLC Methods for Transport and Metabolic Studies
Hroch, Miloš ; Nobilis, Milan (advisor) ; Šatínský, Dalibor (referee) ; Šišpera, Luděk (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate Ing. Miloš Hroch Consultant Doc. PharmDr. Milan Nobilis, CSc. Title of Thesis Development and validation of HPLC methods for transport and metabolic studies The presented PhD thesis deals with the development and validation of chromatographic methods in bioanalysis of drugs and their metabolites. The work provides a theoretical introduction to the field of bioanalysis, using methods of liquid chromatography. Attention was paid to recent trends in the area, particularly with respect to the new types of stationary phases. In the experimental part of the thesis, reader is introduced to a development and validation of several bio-analytical methods using high performance liquid chromatography. The first method concerns with a determination of 5-fluorouracil and its metabolites by HPLC with gradient elution and UV/VIS detection on a column Luna PFP (2). Discussed are mainly specifics for the assay of this group of polar and poorly detectable compounds. The developed and validated method is being used for TDM of patients with rectal cancer. Another discussed method deals with a determination of methotrexate polyglutamates in erythrocytes using isocratic elution on a hybrid...
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