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MRP transporters in the placenta
Dvořáková, Marie ; Čečková, Martina (advisor) ; Pávek, Petr (referee)
The MRP mebrane proteins, which belong to the ABC transporter family, comprise currently 9 members. The MRP transport proteins are expressed in various tissues of the organism, including placenta. The major physiological role of the multidrug transporters is the transport of many endogenous and exogenous compounds, including drugs, across the cell membrane. This thesis summarizes up to date information concerning expression and function MRP transporters in placenta a and in other tisssues in organism. Only five MRP transporters have been detected in placenta, namely MRP1, MRP2, MRP3, MRP5 a MRP8. Expression of all this proteins in placenta changes with progress of the pregnancy. MRP transporters help to protect fetus from potentially toxic substances, on the other hand some of them can facilitate the passage of substances across placenta. Some MRPs possess specific physiological functions in placenta. For example, MRP1 influences apoptosis, MRP5 participates in NO-dependent vasodilatation in fetal vessels.
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Financial Management Analysis of Regions in the Czech Republic and Relatioship to Regional Development Funding
Dvořáková, Marie ; Peková, Jitka (advisor) ; Pucandlová, Miroslava (referee)
Hereby presented diploma thesis discusses the financial management of Czech regions (more accurately "higher-level territorial administrative units") focusing on regional development funding, particularly demonstrated by the example of the South Moravian Region. Through a study of regional financial management the regional budget's income and expenditure have been thoroughly examined, especially those governable by the regions themselves. During the analysis of the South Moravian Region financial system the main focus has been aimed at its regional funding policy outlined by the corresponding strategic documentation entitled South Moravian Region Development Plan. The actual support for regional development in South Moravian Region is financed by the region's budget and a special-purpose fund named Development Fund of South Moravian Region.
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Detekce signálu v rastrovacím elektronovém mikroskopu pomocí detektorů sekundárních elektronů
Konvalina, Ivo ; Hovorka, Miloš ; Dvořáková, Marie ; Müllerová, Ilona
The collection of secondary electrons (SE) was studied for microscopes where the magnetic field penetrates to the specimen surface and for the arrangement with the specimen region free of magnetic field. Collection efficiency of secondary electron detectors varies with their energy and angular sensitivity connected with electrostatic and magnetic field distribution in the specimen region which influences the contrast of SE images. The trajectories of SE with regard to their energy, angular distributions are simulated and secondary electron detectors compared on the basis of calculated collection efficiency. For the verification of the simulated data the standard resolution-testing specimen with Au particles on a carbon substrate was used.
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Prevence tvorby uhlovodíkové kontaminace v SEM
Dvořáková, Marie ; Mika, Filip
Electron beam-induced contamination is one of the most undesirable effects in SEM. In this work the contamination was formed on silicon wafer, copper, aluminium, stainless plate and nickel samples. The contamination was removed by the plasma cleaning (XEI Scientific Evactron De-Contaminator).
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Analýza výběrového řízení na komunikační agenturu
Dvořáková, Marie ; Mikeš, Jiří (advisor) ; Otevřel, Lukáš (referee)
Cílem práce je provedení komplexní analýzy průběhu výběrového řízení na komunikační agenturu, včetně rozboru strategických agenturních dokumentů a právního ošetření výběrového řízení. Práce dále obsahuje komparaci doporučovaných standardů a praxe v ČR a analýzu konkrétního výběrového řízení, zahrnující i identifikaci případných chyb a doporučení na zlepšení postupu. Práce potvrzuje výchozí hypotézu o tom, že dodržování doporučených standardů pomůže oběma stranám nacházet korektním a etickým způsobem vhodné partnery pro dlouhodobou spolupráci.
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