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Pathophysiological mechanisms in idiopathic scoliosis
Boček, Václav ; Štětkářová, Ivana (advisor) ; Beneš, Vladimír (referee) ; Ehler, Edvard (referee)
Pathophysiological mechanisms in idiopathic scoliosis A neurophysiological study of cortical and spinal inhibitory circuits and myogenic aspects of idiopathic scoliosis Author: MUDr. Václav Boček Supervisor: prof. MUDr. Ivana Štětkářová, CSc. INTRODUCTION: Although adolescent idiopathic scoliosis (AIS) represents the most common spinal deformity, its aetiology remains still unknown. The origins of the disease are spotted at the local level (the spine and the paraspinal muscles) and/ or general - endocrinological (melatonin, leptin), sensory (vestibular system, impaired own body image) and at the level of motor cortex, where the impaired sensorimotor integration has not been properly debated nor documented. The central inhibitory mechanisms are still somewhat omitted. AIM OF THE STUDY: Our study was focused on local changes at the level of paraspinal muscles and central inhibitory mechanisms at the brain and spinal cord level. PATIENTS AND METHODS: We compared AIS patients and healthy controls (HC). Firstly We performed needle EMG of paraspinal muscles. Secondly perioperative muscle biopsies were collected during correctional surgery focused on the distinguishing type I and II muscle fibres proportion. We also studied spinal inhibition with the spinal inhibitory reflex cutaneous silent period. Motor...
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Program of Practical Prevention of Cardiovascular Disease in Lower-secondary School Students
Váňová, Zdenka ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
This diploma thesis deals with the risk factors of cardiovascular diseases in children and their prevention. It briefly describes the influenced risk factors of these diseases and the prevention of their occurrence. It also focuses on preventive programs of cardiovascular diseases in our country and in the world and describes them in more detail. It also provides an overview of current biology textbooks for the lower-secondary school and their evaluation based on whether and to what extent they deal with the issue of cardiovascular diseases. The aim of the thesis is to create a program directed at the prevention of cardiovascular diseases in children at the lower-secondary school, to use it in practice at a selected lower-secondary school and to evaluate its effectiveness in a subsequent questionnaire.
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Growth and Proportional Changes in Chidren at Grammar Schools
Zeťková, Marie ; Vančata, Václav (advisor) ; Ehler, Edvard (referee)
This diploma thesis describes an anthropological survey of pupils in the 8th and 9th grades of certain primary schools in the Zlin Region (Czech Republic), pertaining to which the data thus obtained were subsequently processed and evaluated. The aim of the work was to analyse proportional changes and the biological maturity exhibited by the members of the probands through KEI, based on empirical data, in addition to determining the given somatotype according to the method of Heath & Carter (1967). ANTROPO 2000.2 software was utilized for processing the data. The findings of said research are compared with the data reported by the National Anthropological Survey (Czech Republic, 2001).
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Opinion of Pupils on Consumption of Marijuana: Prevention and Health Risks
Krajníková, Veronika ; Ehler, Edvard (advisor) ; Vančata, Václav (referee)
The aim of this thesis is to sum up the information connected with marijuana and cannabis topic in relation to their effects, use and misuse. At the beginning of my research three hypotheses have been determined . They have been based on the electronic questionnaires which have been answered by respondents in lower secondary schools. The results of my thesis are shown in its applied part. According to the questionnaire the first hypothesis has been confirmed. 17,68 % of survey participants have tried marijuana at least once in their lives. The second hypothesis has not been taken to be true, because although there is a prevention in primary schools, it doesn't provide pupils ' awareness of this problem completely. The third hypothesis has been proved false as well, because more than 50 % of the respondents said that they have already learnt about cannabis in Science. Key words: marijuana, hemp drugs, cannabis, Cannabis sativa
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Y-chromosomal polymorphisms in the Czech population with focus on Moravian Valachs: evolutionary anthropology study.
Ehler, Edvard ; Vančata, Václav (advisor) ; Černý, Viktor (referee) ; Brdička, Radim (referee)
1 Abstract Aim: This study presents an evolutionary anthropology approach to the history of Moravian Valachs. The origins of Valach population are approached by evaluating the admixture event that marked the appearance of Moravian Valachs. Methods & data: Focus of my Ph.D. project lies on Y-chromosomal variation, using 12 Y-STR loci haplotype to compute population genetic statistics, to infer Y-chromosomal haplogroup information and to compare Moravian Valachs to other European populations. Admixture analysis was performed. Our data set contains haplotypic information from 44 populations with the total of 4757 individuals. Moravian Valachs are presented by 94 DNA samples. Results: Our data reveal a decreased genetic variability in Moravian Valachs compared to other Central European populations. This feature is most probably caused by isolation of Valach population. Multidimensional scaling and comparison of FST distances shows Valach population as related to populations from Poland, Romania and Macedonia. Shared haplotypes and AMOVA tests place the Valachs to the Central European region. Also admixture analysis, as well as demographic and historical data, stresses the influence of autochthonous population of Moravia in the forming of Moravian Valachs. Conclusion: Moravian Valachs represent a hybrid...
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