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National Repository of Grey Literature

24 records found  11 - 20  jump to record:

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	Nucleosid fosfonové kyseliny a odvozené oligonukleotidy: Strukturní diversita vs biologické vlastnosti Rosenberg, Ivan ; Barvík, I. ; Buděšínský, Miloš ; Kočalka, Petr ; Králíková, Šárka ; Liboska, Radek ; Pačes, Ondřej ; Páv, Ondřej ; Petrová, Magdalena ; Pohl, Radek ; Pressová, Martina ; Rejman, Dominik ; Votruba, Ivan ; Točík, Zdeněk This article deals with the biological and physico-chemical properties of both isopolar, isosteric and non-isosteric phosphonate nucleotides and oligonucleotides. Detailed record
	Nové nukleosidfosfonové kyseliny jako inhibitory thymidinfosforylázy Kočalka, Petr ; Rinnová, Markéta ; Vaněk, Václav ; Rejman, Dominik ; Votruba, Ivan ; Tomečková, Ivana ; Králíková, Šárka ; Petrová, Magdalena ; Páv, Ondřej ; Pohl, Radek ; Buděšínský, Miloš ; Liboska, Radek ; Točík, Zdeněk ; Rosenberg, Ivan Several sugar-modified thymine-containing nucleoside phosphonic acids were found as a strong inhibitors of thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. Detailed record
	Pyrimidinové 1-[2-(fosfonomethoxy)propyl] deriváty: Jejich synthésy a využití jako potenciální inhibitory thymidinfosforylásy (PD-ECGF) z SD-lymfomu Pomeisl, Karel ; Votruba, Ivan ; Holý, Antonín ; Pohl, Radek In this study a novel method of transformation of HOCH2 group to FCH2 was successfully applied to the preparation of fluorine-containing pyrimidine 1-[3-fluoro-2-(phosphonomethoxy)-propyl] derivatives (FPMP compounds). The key displacement of hydroxy group with fluorine in better avalaible (S)- and (R)- 1-[3-hydroxy-2-(phosphonomethoxy)-propyl] derivatives (HPMP compounds) was performed using perfluorobutane-1-sulphonyl fluoride in the presence of DBU. Detailed record
	Acyklické nukleosid fosfonáty a inhibice lidské telomerázy Hájek, Miroslav ; Matulová, Naděžda ; Votruba, Ivan ; Holý, Antonín ; Tloušťová, Eva Diphosphates of acyclic nucleoside phosphonates were evaluated for their ability to inhibit human telomerase. Detailed record
	Design a syntéza 5,6-disubstituovaných uracilových derivátů jako účinných inhibitorů thymidinfosforylasy Nencka, Radim ; Votruba, Ivan ; Hřebabecký, Hubert ; Tloušťová, Eva ; Horská, Květoslava ; Masojídková, Milena ; Holý, Antonín We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Detailed record
	N6-methyl-AMP-hydrolasa aktivuje N6-substituované purinové ANPs Schinkmanová, Markéta ; Votruba, Ivan ; Holý, Antonín Identification and characterization of a new enzyme, N6-methyl-AMP aminohydrolase, that is responsible for the conversion of N6-cyclopropyl-PMEDAP to biologically active PMEG. Detailed record
	Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds Otmar, Miroslav ; Masojídková, Milena ; Votruba, Ivan ; Holý, Antonín 2,6-Diamino-9-benzyl-9-deazapurine and 9-benzyl-2,6-bis(benzylamino)-9-deazapurine were synthesized by reductive cyclization of the corresponding 6-cyanomethyl-5-nitropyrimidines. Both compounds exhibit cytostatic activity in human T-lymphoblastoid CCRF-CEM cells. Detailed record
	HPMPApp as a substrate toward replicative DNA polymerases ŕ, ë and .epsilon Birkuš, Gabriel ; Votruba, Ivan ; Holý, Antonín ; Otová, B. Detailed record
	Phosphorylation of enentiomers of HPMPG Krejčová, Romana ; Horská, Květoslava ; Votruba, Ivan ; Holý, Antonín Detailed record
	An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives Otmar, Miroslav ; Votruba, Ivan ; Holý, Antonín Detailed record

National Repository of Grey Literature : 24 records found   11 - 20  jump to record:

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