Original title:
Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds
Authors:
Otmar, Miroslav ; Masojídková, Milena ; Votruba, Ivan ; Holý, Antonín Document type: Papers Conference/Event: Chemistry of Nucleic Acid Components. Symposium /12./, Špindlerův Mlýn (CZ), 2002-09-03 / 2002-09-08
Year:
2002
Language:
eng Abstract:
2,6-Diamino-9-benzyl-9-deazapurine and 9-benzyl-2,6-bis(benzylamino)-9-deazapurine were synthesized by reductive cyclization of the corresponding 6-cyanomethyl-5-nitropyrimidines. Both compounds exhibit cytostatic activity in human T-lymphoblastoid CCRF-CEM cells.
Keywords:
cytostatic activity Project no.: CEZ:AV0Z4055905 (CEP), OC D13.20 Funding provider: GA MŠk Host item entry: Chemistry of Nucleic Acid Components
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0090076