Original title: Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds
Authors: Otmar, Miroslav ; Masojídková, Milena ; Votruba, Ivan ; Holý, Antonín
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components. Symposium /12./, Špindlerův Mlýn (CZ), 2002-09-03 / 2002-09-08
Year: 2002
Language: eng
Abstract: 2,6-Diamino-9-benzyl-9-deazapurine and 9-benzyl-2,6-bis(benzylamino)-9-deazapurine were synthesized by reductive cyclization of the corresponding 6-cyanomethyl-5-nitropyrimidines. Both compounds exhibit cytostatic activity in human T-lymphoblastoid CCRF-CEM cells.
Keywords: cytostatic activity
Project no.: CEZ:AV0Z4055905 (CEP), OC D13.20
Funding provider: GA MŠk
Host item entry: Chemistry of Nucleic Acid Components

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0090076

Permalink: http://www.nusl.cz/ntk/nusl-28342


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers