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Computational Studies of Interactions of Small Molecules with their Biological Targets
Nekardová, Michaela ; Hobza, Pavel (advisor) ; Berka, Karel (referee) ; Kabeláč, Martin (referee)
The thesis specializes in the computational description of pharmaceutically important compounds. A substantial number of pharmaceutical drugs are small molecules that are bound to an active site of an enzyme by the "lock (binding site) and key (drug)" model through non-covalent interactions. The association of enzymes with drugs cause an increase or decrease in the activity of enzymes. The main topic is focused on the computational elucidation of the structural basis for the interactions of the purine-like compounds with the enzyme cyclin- dependent kinase 2 that belongs to the protein-kinase enzyme family. These enzymes play an important role in the cell cycle regulation; their increased activity significantly contributes to the loss of control over cell proliferation, which is one of the primary causes of cancer cell formation. The study describes the binding motifs of roscovitine, which shows an inhibitory effect on the function of cyclin-dependent kinases, and its analogues containing bioisosteric central heterocycles in the complex with cyclin-dependent kinase 2. The binding affinity between the cyclin-dependent kinase 2 enzyme and the inhibitors was quantified as calculated binding scores and evaluated in relation to the conformation of the optimized structures. The hybrid model combining the...
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Comparison of methods of identification of anaerobic threshold in the cycling part of triathlon
Berka, Martin ; Kovářová, Lenka (advisor) ; Horčic, Josef (referee)
Tittle: Comparison of methodologies for the identification of anaerobic threshold in cycling part of the triatlon Triathlon is an endurance sport combining in a complex of three different sports - swimming, cycling and running. It is a time-consuming sport, where the effectiveness of the training must be at a high level. From the structure of performance in triathlon and the related management training results as the most important prerequisite of effective training to know the individual tracks heart rate and achieved watt performance on the level of the individual anaerobic threshold. To identify and track these values using are used continuous measurements and verifications. One of the most commonly used methods is load diagnostics. Objective: The aim of the thesis is to research literature on load diagnostics. Based on the findings obtained to choose the most frequently used diagnostic test load, which is than applied to the experimental group and the results are statistically compared showing whether there are signifiant differences in the results obtained from the use of different tests. Furthermore, to continue to determine which tests are the most appropriate for evaluation of fitness triathlon in the cycling part of the triathlon. Methodology: The selection and use of selected tests:...
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Verification of the Cyclus II for evaluating the performance and level of the training in the triathlon
Berka, Martin ; Kovářová, Lenka (advisor) ; Horčic, Josef (referee)
Title: Verifying the device Cyclus 2 for performance evaluation and training Triathlon Objective: The aim is to verify the suitability of the device Cyclus 2 for triathletes stressful diagnosis and suggest its use for performance evaluation and trénovanosti during RTC. Methods: The work is qualitative in nature with elements of the description and exploration. Results: The result of the work is to create a list of appropriate tests for analyzing training and performance in triathlon and their inclusion in the RTC. Then transfer the user interface device to create and czech manual for its operation in Czech. The most appropriate test for diagnosing trénovanosti and performance in triathlon roundedconsider a test that provides valuable information on growth performance during the annualtraining cycle. Another good test for triathletes is the Wingate test on the ability to work the muscles in the anaerobic mode. Test maximum cadence, maximum strength and CPI test is not stressful for the diagnosis of triathletes too important, but can be used to obtain an overall view of the level of cycling performance. Conconiho test can be used as a simpler butless accurate alternative test round. Keywords: cycling, diagnostics, perseverance
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Profiling translation of conceptual schemas to XML schemas
Berka, Lukáš ; Nečaský, Martin (advisor) ; Holubová, Irena (referee)
In the present work we analyze the algorithm that was introduced in [4]. The algorithm performs a translation of a conceptual schema to an XML schema expressed in the XML Schema language. We look for limitations of the algorithm and try to discover parameters that can be potentially used to influence its behavior. We propose solutions to the most serious limitations. Also, we introduce a concept of a translation profiling. The concept is based on a configuration that contains a set of parameters. We modify the algorithm to use the user requirements specified in the configuration. Thanks to the improvements, the new algorithm works with the concept of XML Namespaces, uses XML Schema designs and also, focuses on an elimination of redundancy. The elimination of redundancy in an output of the algorithm is an important part of this work and we create a formal model that helps us to solve this task.
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Work and Importance of Medical Clowns
Berka, Tomáš ; SEDLÁČEK, Martin (advisor) ; BERGMAN, Aleš (referee)
This master thesis presents a view of work and impotence of medical clowns in Czech hospital facilities. It unveils the organizational structure and history of the same name company, which sponsors medical clowns in the Czech Republic. It presents all the important parts of complex performance that are essential for medical clowns. Therefore, the clowns are able to visit patients and use their artistic performance to pozitively influence their psychical condition. This leads to patients‘ physical health improvement. The thesis defines „klauniáda“ as a means to reach those goals and presents specific patters of theatrical performace in hospital facilities. It deals with structure of klauniády with use of particular stories, author’s life experience and proffesional researches. It also answers the questions related to the medical clowns‘ contribution.
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The influence of geometry and cutting tool parameters on residual stress during machining of the pressure containers
Berka, Martin ; Kouřil, Karel (referee) ; Strejček, Jan (advisor)
This thesis deals with the influence of changes in cutting parameters and tool geometry on residual stress inside the material. I examine the influence by deep drilling. Changing the cutting parameters concerns the alteration of the tool feed and the pressure of the coolant during the process. The influence of tool geometry is studied by using two different single edge cannon drills. The research was realized in cooperation with Bosch Diesel Ltd. The theoretical part includes a description of the injection system, in which a high-pressure container is contained. The high-pressure container was used to evaluate the influence of the cutting parameters and tool geometry on residual stress. Furthermore, the theoretical part deals with the deep drilling technology used and the theory of residual stresses. The practical part shows the measurement parameters and the corresponding results. In the conclusion of this thesis, a technical-economic evaluation of the measurement is conducted.
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Planning the construction contract by the contractor
Dáňa, Tomáš ; Berka, Jan (referee) ; Nový, Martin (advisor)
The diploma thesis deals with the process of planning the costs of a contract for construction. The thesis describes the pricing, contract for construction, construction time models, and allocation of costs during the construction. It introduces a particular contract for construction, which is analysed mainly with regard to the allocation of costs during the construction. The thesis introduces also alternative solutions for the allocation of costs during the construction. The purpose of the thesis is to compare the alternative solutions with the reality, and analyse the allocation of costs during the construction.
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Tail units design of VUT 100 aircraft made out composite
Berka, Martin ; Cejpek, Jakub (referee) ; Mališ, Michal (advisor)
This Master´s thesis describes the design of composite horizontal tail of VUT 100 aircraft. Load calculation and selection of the critical load cases is performed. Internal structure of stabilizer and right elevator is designed. Construction materials are chosen and the structure of the composite materials is proposed. FEM models of stabilizer and the right elevator are created in MSC Patran system and consequently the strength test of the models for the selected load cases is executed using MSC Nastran software and COMPOST.
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Precision forging
Berka, Martin ; Peterková, Eva (referee) ; Lidmila, Zdeněk (advisor)
This bachelor´s thesis deals with the technology of precision forging. The thesis describes basic distribution of the forging according to the nature of the material flow and his procedure. After the introductory part this thesis deals with the analysis of the methods of the drop forging with fin groove. The next section contains a description, parameters and methods of precision forging. Technical a economical evaluation of the component technology is as a conclusion of the thesis.
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