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Using thermochromic systems for testing heat distribution
Klimeš, Jan ; Sedlaříková, Marie (referee) ; Zatloukal, Miroslav (advisor)
This thesis deals with principles of thermochromism and its possible applications in heat distribution testing. Theoretical part describes mechanisms which allow the thermochromic properties of the substances. Particular attention is paid to cholesteric liquid crystals. Ability to measure the heat for this type of liquid crystals was varified. Also long service life in high humidity environment, enviroment with intense UV radiation, cyclic changes in temperature or immersion in water was tested. A possibility of their practical use in diagnosis was verified as well. Specifically mapping of heat distribution on an assembled PCB. Conclusion contains comparison and evaluation of this method in terms of accuracy, user comfort and economic advantages compared to conventional infrared sensors.
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Cathedral today
Klimeš, Jakub ; Mléčka, Jan (referee) ; Štěpán, Marek (advisor)
This project focuses on an ideal solution for restoring the roof of Notre-Dame in Paris, which burned down together with its spire on April 15, 2019. The main motive behind the design was to create a quiet space that will serve as a memorial of the fire and reflect the unity of the society that contributed to the rebuilding found. The primary step of the whole reconstruction is to find an adequate way of renewal and its ethical boundaries. Main attention is focused on the roof and on the spire of the cathedral. As a tribute to medieval builders who consecrated their lives into this magnificent piece of work. The exterior of the new design has the same silhouettes and proportions that it has got eight centuries ago, but with a touch of a modern day aesthetics. When designing the interior of the roof, it was really important to maintain a clear representation of Gothic architecture – the balance between darkness and light. The space is divided into two parts. The first part represents darkness, as an obstacle, which each of us has to overcome. The second part is full of natural light that seems to tear the roof of the cathedral and illuminates the entire space inside. At the heart of the design is a gem that matters the most, life. The spire of the cathedral is designed with four pillars that symbolize the connection of mind-spirit-body with physical world The idea of the spire reflects these seemingly different things, but together they unite into one piece.
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Societal and governmental perspective of patients with Dravet syndrome and Lennox-Gastaut syndrome
Krejčová, Martina ; Klimeš, Jiří (advisor) ; Grega, Dominik (referee)
Societal and governmental perspective of patients with Dravet syndrome and Lennox-Gastaut syndrome Author: Martina Krejčová Supervisor: PharmDr. Jiří Klimeš, Ph.D. Consultant: PharmDr. David Suchánek Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) are rare diseases. The orphan drug Epidyolex is indicated to reduce the frequency of seizures in these diseases. The aim of this work is to provide a comprehensive overview of orphan drug legislation and the potential of its reimbursement from health insurance and determine the costs of DS and LGS from a societal and governmental perspective. Methods: The data for the analysis is obtained from the questionnaire focused on the social benefit drawdown, increase in household costs, and loss of productivity of patients and their caregivers. Respondents are recruited in a cooperation with patient organisations and specialised centres. The costs from both perspectives are determined by adding the expenses of the health insurance company and the costs of lost productivity (societal perspective), or the costs to the social security system (governmental perspective). The human capital approach method (HCA) is used for the societal...
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Neaditivní mezimolekulární interakce
Kovačovský, Ján ; Klimeš, Jiří (advisor) ; Žonda, Martin (referee)
Non-additive intermolecular interactions, involving three or more molecules, present a significant challenge in accurately predicting molecular behaviour and properties of materials. These interactions, characterized by their high-dimensional and unpredictable nature with molecular position, cannot be reliably estimated by simply summing pair- wise interactions between molecules. Incorporating three-body non-additive interactions into first-principles quantum mechanical approaches can greatly enhance agreement with experimental data, often achieving remarkable reductions in deviations. 1
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Societal and governmental perspective of patients with Dravet syndrome and Lennox-Gastaut syndrome
Krejčová, Martina ; Klimeš, Jiří (advisor) ; Grega, Dominik (referee)
Societal and governmental perspective of patients with Dravet syndrome and Lennox-Gastaut syndrome Author: Martina Krejčová Supervisor: PharmDr. Jiří Klimeš, Ph.D. Consultant: PharmDr. David Suchánek Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) are rare diseases. The orphan drug Epidyolex is indicated to reduce the frequency of seizures in these diseases. The aim of this work is to provide a comprehensive overview of orphan drug legislation and the potential of its reimbursement from health insurance and determine the costs of DS and LGS from a societal and governmental perspective. Methods: The data for the analysis is obtained from the questionnaire focused on the social benefit drawdown, increase in household costs, and loss of productivity of patients and their caregivers. Respondents are recruited in a cooperation with patient organisations and specialised centres. The costs from both perspectives are determined by adding the expenses of the health insurance company and the costs of lost productivity (societal perspective), or the costs to the social security system (governmental perspective). The human capital approach method (HCA) is used for the societal...
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Remote and passive speech monitoring application
Klimeš, Jiří ; Mikulec, Marek (referee) ; Kováč, Daniel (advisor)
Motor speech disorders in patients with Parkinson’s disease collectively referred to as hypokinetic dysarthria, occur in the early phase of the disease. Language plays an essential role in classifying speakers into healthy and those with dysarthria. Author explains which aspects of speech are most often affected. Then explains how mobile applications work on the Android operating system, and if it is possible to use them in passive and distant speech monitoring. Then the topic of voice call recording is described and how is it possible to implement this solution. Such application is then designed and partially developed.
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Analysis of tourism in the archaeological site of Machu Picchu
Břežná, Tereza ; Vilímek, Vít (advisor) ; Klimeš, Jan (referee)
This bachelor thesis is an overview of the analysis of tourism in the archaeological monument of Machu Picchu with a focus on overturism. Tourism is an ever-evolving sector that brings both positive and negative aspects to places, such as overturism, which is also on Machu Picchu. The work also presents a brief history of the object and life of the Incas and the basic physical and geographical setting of the place, including natural hazards. The main goal of this work is the analysis of tourism at Machu Picchu and its development in the period 1980-2019. The research is also focused on the analysis of attendance of tourists during the year in correlation with weather and air transport. Part of the analysis focuses on research of the number of tourists in acreage and the population of Machupicchu village. The aims of the work also deal with the regulatory mechanisms and comparison of Machu Picchu with other UNESCO monuments. The bachelor thesis uses methods of calculating the number of tourists divided by the area in m2 and the number of tourists divided by the population of Machupicchu. Machu Picchu is a heritage site that has been burdened by overtourism in a long period of time. Its attendance is rising sharply every year, in 2019 it was visited by over 1.5 million tourists from around the world....
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Contour lines to heightfield conversion
Klimeš, Jonáš ; Pelikán, Josef (advisor) ; Dupej, Ján (referee)
Title: Contour lines to heightfield conversion Author: Jonáš Klimeš Department: Department of Software and Computer Science Education Supervisor: RNDr. Josef Pelikán, Department of Software and Computer Science Education Abstract: The task of this project is to design and test algorithms for semiautomatic contour lines conversion to height field. This work tries to solve following problems: automatic connection of disconnected contour lines, adjacent paths finding, semiautomatic ordering of contour lines with user assistance, creating of terrain height field using Catmull-Rom splines or radial basis functions. A part of this thesis is an experimental application, which implements these algorithms and displays the process of conversion. Program input are in form of contour lines in SVG vector format. Output 3D meshes are in Wavefront OBJ format. Keywords: contour lines, height field, terrain
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Development of HPLC methods for analytical evaluation of drug products and model studies of natural degradation of drug residues.
Nejedlý, Tomáš ; Klimeš, Jiří (advisor) ; Karlíček, Rolf (referee) ; Mikuš, Peter (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate Mgr. Tomáš Nejedlý Supervisor prof. RNDr. Jiří Klimeš, CSc. Title of Doctoral Thesis Development of HPLC methods for analytical evaluation of drug products and model studies of natural degradation of drug residues The presented doctoral thesis describes two areas of pharmaceutical analysis. The first part is focused on development of validated chromatographic methods for pharmaceutical-analytical assesment of drug products and their rutine use in quality control laboratories. The second part deals with the very actual topic of environmental analysis and residues of pharmaceutical substances in sewage and surface water. The first developed method is suitable for quality evaluation of cream dosage forms containing aciclovir active substance. This method is suitable for assay of active substance and its three related substances. In addition it is validated for assay of preservatives contained in cream base. The second chromatographic method is developed for determination of tablets containing 1 mg of risperidone antipsychotic drug per tablet. This method was validated for active substance assay and the four mostimportant pharmacopoeial impurities. The last method is...
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