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Processing and Visualization of Diagnostic Data from a Bionic Upper Limb Prosthesis
Mahdalík, Ondřej ; Lazúr, Juraj (referee) ; Hynek, Jiří (advisor)
Bionické protézy se běžně používají k tomu, aby pacientům pomohly efektivněji vykonávat každodenní činnosti. Zahrnují různé metody získávání vstupu od uživatele a používají elektromotory k ovládání prstů a/nebo jiných částí končetiny. Bohužel míra odmítnutí protézy dosahuje v průměru 44 % [64], což znamená, že téměř polovina pacientů přestane protézu používat. Protéza Z-Arm od společnosti Z-Bionics se pokouší řešit nízkou míru akceptace mimo jiné tím, že zaznamenává diagnostické údaje a pomáhá pacientovi, když detekuje nesprávné používání nebo možnou vadu protézy. Protože však návštěvy pacientů nejsou dostatečně časté, aby specialisté získali aktuální diagnostické údaje, je třeba navrhnout vhodný způsob jejich získávání na dálku. Jako řešení byla implementována mobilní aplikace využívající Bluetooth ke komunikaci s protézou doprovázená rozšířením interní webové aplikace o nové stránky, koncové body API a databázi MongoDB. Ačkoli testování s pacienty stále probíhá, první dojmy zaměstnanců a pacientů jsou vesměs pozitivní a naznačují možné zlepšení komfortu při používání protézy.
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Design of a Crash-Test Dummy
Sedláčková, Martina ; Coufal, Tomáš (referee) ; Bilík, Martin (advisor)
The main objective of this thesis is construction of crash test dummy for vehicle-pedestrian crash tests. There is review of nowadays used crash test dummies types in the introduction of this thesis. This is followed by part describing construction itself. Chapter about construction begins by characterizing of used materials features in relation with real human body physiology. Main part of chapter is describing construction of crash test dummy’s skeleton and its individual components including 3D modelling and strength analysis. Thesis is finished by cost assessment.
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On the kinematics of legged robots
Hrubý, Tomáš ; Kopečný, Lukáš (referee) ; Burian, František (advisor)
This bachelor thesis deals with the topic of kinematics of walking robots. It is aimed at introducing the problems of mobile robots and the concepts of solving locomotion and stability of robots with different numbers of limbs. Furthermore, the thesis discusses the mathematical principles leading to the description of the limbs of robots and to the description of their motion. These principles are then applied to the specific case of a six-legged walking robot. The description of the limbs with respect to the coordinates and the servomotor setup is resolved. Then the forward motion of the robot is modeled and the result is shown in the simulation.
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On the kinematics of legged robots
Hrubý, Tomáš ; Kopečný, Lukáš (referee) ; Burian, František (advisor)
This bachelor thesis deals with the topic of kinematics of walking robots. It is aimed at introducing the problems of mobile robots and the concepts of solving locomotion and stability of robots with different numbers of limbs. Furthermore, the thesis discusses the mathematical principles leading to the description of the limbs of robots and to the description of their motion. These principles are then applied to the specific case of a six-legged walking robot. The description of the limbs with respect to the coordinates and the servomotor setup is resolved. Then the forward motion of the robot is modeled and the result is shown in the simulation.
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Molecular mechanisms of vertebrate limb regeneration
Onhajzer, Jakub ; Krylov, Vladimír (advisor) ; Soukup, Vladimír (referee)
Limb regeneration fascinates innumerable scientists for decades. Urodele amphibians can regenerate their limbs perfectly. This ability is preserved for a whole lifetime. However, they are not the only ones who regenerate their limbs. Second species are anuran amphibians, but their ability to promote limb regeneration take place only throughout a larval stage. Both groups belong to amphibians. Limbs are regeneated by the process called epimorphosis. The primary process is formation of blastema, mass of heterogeneous dedifferetiated cells, which are unipotent with the capacity to redifferentiate into only one cell type. Essential factor is the regulation of limb regeneration by numerous molecular mechanisms in order to achieve the perfect limb shape, without unwanted tumors. Mechanisms allowing limb regeneration in lower vertebrates would be applied via regenerative medicine in higher vertebrates in the future. Keywords: regeneration, limb, epimorphosis, dedifferentiation, vertebrates
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Antero-posterior polarization of body appendages in vertebrates
Smlsal, Dan ; Soukup, Vladimír (advisor) ; Krylov, Vladimír (referee)
Body appendages of vertebrates are structures developing during embryonal stages through lateral outgrowth from main body axis. Despite their different composition and high diversity, all these structures are organised along three main axes. Antero-posterior polarization is the most significant in body appendage differentiation. These polarized differentiation changes are best understood in the limbs, where they are controlled by the organizing centre named zone of polarizing activity (ZPA). This centre interacts with another centre named apical ectodermal ridge (AER), which mainly governs limb outgrowth laterally from the body axis. ZPA produces Sonic hedgehog (Shh), along with other signalling molecules participating in the polarization. Shh is a key part of highly conserved signalling pathway common to polarized structures and is influenced by retinoic acid (RA), which plays role in the ZPA creation. ZPA activity stimulates secretion of fibroblast growth factors (Fgf) and bone morphogenic proteins (Bmp). All these signalling pathways ensure correct differentiation of appendages through interaction and concentration-dependent mechanisms. The goal of this thesis is to introduce the mechanisms of polarization in other appendages, such as external genitalia and branchial arch derivates to the reader,...
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Molecular mechanisms of vertebrate limb regeneration
Onhajzer, Jakub ; Krylov, Vladimír (advisor) ; Soukup, Vladimír (referee)
Limb regeneration fascinates innumerable scientists for decades. Urodele amphibians can regenerate their limbs perfectly. This ability is preserved for a whole lifetime. However, they are not the only ones who regenerate their limbs. Second species are anuran amphibians, but their ability to promote limb regeneration take place only throughout a larval stage. Both groups belong to amphibians. Limbs are regeneated by the process called epimorphosis. The primary process is formation of blastema, mass of heterogeneous dedifferetiated cells, which are unipotent with the capacity to redifferentiate into only one cell type. Essential factor is the regulation of limb regeneration by numerous molecular mechanisms in order to achieve the perfect limb shape, without unwanted tumors. Mechanisms allowing limb regeneration in lower vertebrates would be applied via regenerative medicine in higher vertebrates in the future. Keywords: regeneration, limb, epimorphosis, dedifferentiation, vertebrates
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Design of a Crash-Test Dummy
Sedláčková, Martina ; Coufal, Tomáš (referee) ; Bilík, Martin (advisor)
The main objective of this thesis is construction of crash test dummy for vehicle-pedestrian crash tests. There is review of nowadays used crash test dummies types in the introduction of this thesis. This is followed by part describing construction itself. Chapter about construction begins by characterizing of used materials features in relation with real human body physiology. Main part of chapter is describing construction of crash test dummy’s skeleton and its individual components including 3D modelling and strength analysis. Thesis is finished by cost assessment.
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