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Labour market and spatial mobility in Plzen region
Duda, Petr ; Čermák, Zdeněk (advisor) ; Matušková, Alena (referee)
The Czech Republic underwent considerable social, political and economic changes after 1989. An important step was the creation of the labor market where jobs and wages were created based on market supply and demand. Due to effects of these market forces, unemployment was an unavoidable consequence. . Closely related to this was workforce flexibility which over the years became increasingly important. People migrating for work also had an effect on the housing market. The main objective of this thesis is to analyze the labor market in the Plzeň Region and the related spatial mobility since 2000 (with a brief development in the 90's). Another important objective is to determine to what extent the migration of the population is affected by the labor market situation and developments in the housing market. Two major institutions were used as the data source for processing thse reviews. The Labour Market in the Plzeň Region was mapped on the basis of data from the Labour Office in Plzeň. Data on development of spatial mobility and the housing market was gained from the Czech Statistical Office online databases and also from the Regional Office of CSO in Plzen. Key words: migration, labour market, housing market, Plzen
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Approaches of nursery school teachers to foreigners' children
Barjaktarevičová, Zuzana ; Bittnerová, Dana (advisor) ; Levínská, Markéta (referee)
The increasing number of foreigners living in the Czech Republic causes the accrual of children from the foreign families in the educational institutions. The teachers in Czech nursery schools face the situation when they have to adjust their work and help these children integrate with the community. The contents of this thesis are the possibilities that the Czech educational system offers to foreigners' children and the views of teachers of some nuersery schools in Prague. Keywords Foreigners Integration Nursery School Migration Preschool Education Teacher
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The biological importance of CAS SH3 domain tyrosine phosphorylation
Janoštiak, Radoslav ; Brábek, Jan (advisor) ; Dvořák, Michal (referee)
Protein CAS is a major tyrosine-phosphorylated protein in cells transformed by v-crk and v-src oncogenes. It is a multidomain adaptor protein, which serves as a scaffold for assembly of signalling complexes which are important for migration and invasiveness of Src-transformed cells. A novel phosphorylation site in N-terminal SH3 domain was identified - tyrosine 12 located on binding surface of CAS SH3 domain. To study biological importance of tyrosine 12 phosphorylation, non-phosphorylable (Y12F) and phosphomimicking ( Y12E) mutant of CAS were prepared. We found that phosphomimicking mutation Y12E leads to decreased interaction of CAS SH domain with kinase FAK a phosphatase PTP-PEST and also reduce tyrosine phosphorylation of FAK. Using GFP-tagged CAS protein, we show that Y12E mutation caused delocalization of CAS from focal adhesion but has no effect on localization of CAS to podosome-type adhesion. Non-phosphorylable mutation Y12F cause hyperphosphorylation of CAS substrate domain and decrease turnover of focal adhesion and associated cell migration of mouse embryonal fibroblasts (MEFs) independent to integrin singalling. Analogically to migration, CAS Y12F decrease invasiveness of Src-transformed MEF. The results of this diploma thesis show that phosphorylation of Tyr12 in CAS SH3 domain is...
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Attitude of Czech Public to Accepting of Refugees in February 2017
Červenka, Jan ; Pilecká, Jarmila
In February 2017 Public Opinion Research Centre included a block of questions connected to accepting refugees from countries affected by military conflicts. Questions focused mainly on opinion towards accepting refugees from concrete regions (Ukraine, Middle East and North Africa), concern with the current situation around refugees and perception of the situation as a security threat. Press release shows also the comparison with public opinion in Poland.
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The role of dipeptidyl peptidase-IV and homologous proteases in migration and invasion.
Fejfarová, Edita ; Rösel, Daniel (referee) ; Bušek, Petr (advisor)
Migration and invasion are processes which naturally occur in organism during embryogenesis, immune reactions or wound healing. These processes are very important factors in some serious diseases like rheumatoid arthritis and carcinogenesis. There is no doubt about contribution of proteases in these processes-many of them degrade extracellular matrix and thereby facilitate the movement of cells. While dipeptidylpeptidase-IV cleaves solely two amino acids from N-terminus so it is not considerably involved in ECM degradation. DPPIV and its homologues recognize peptides with proline on penultimate position, which causes resistance to ordinary types of proteases. Substrates of DPPIV and its activity homologues include chemokines implicated in signalling of migration - their cleavage and thus inactivation present DPPIV and DPPIV-like molecules as modulators of cell migration signalling in choriocacinoma, neuroblastoma, on Sézary cells or epithelial cells migrating in response to injury. Another activity of some DPPIV-like proteases is binding to the extracellular matrix proteins, when are helping in the attachment of cells and thus affect the migratory ability of the cells like ovarian cancer cells, prostate cancer cells, melanoma cells or kidney cells. Effects on migration and invasion have also...
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Role of cAMP signaling in phagocyte migration
Dáňová, Klára ; Paňková, Daniela (referee) ; Kamanová, Jana (advisor)
Cell migration plays a key role in a wide diversity of biological processes. Migration enables phagocytic cells to localize into the site of inflammation and to lymph nodes, thereby leading to initiation of innate and adaptive immune responses, respectively. The signal transduction that coordinates phagocyte migration consist of diverse signaling proteins, being often under control of 3'-5'-cyclic adenosine monophosphate (cAMP) and its two effectors, protein kinase A (PKA) and Epac (exchange protein activated by cAMP). Small GTPase Rap is activated by Epac and controls phagocyte migration via activation of RAPL and RIAM proteins. On the other hand, PKA regulates cell migration via modulation of activity of other proteins, which comprise actin, integrins, small GTPases Rho, Rac, Cdc42 as well as protein VASP. A prominent feature of cAMP signalization is its spatio-temporal organization. Therefore, besides description of cAMP-regulated signaling cascades in cell migration, this bachelor thesis also depicts how changes of activity of cAMP effectors in time and place are involved in regulation of cell movement.
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Population Development of Kazakhstan: Geographic, Economic and Geopolitical aspects
Rodionov, Viktor ; Pavlík, Zdeněk (advisor) ; Tomeš, Jiří (referee)
Geopolitical role and population development of the Republic of Kazakhstan: recent developments and prospects V. Rodionov Abstract Present research is an attempt to define the influence of the demographic factor on geopolitical development of Kazakhstan. Kazakhstan is of a specific interest herein due to its strategically important geographical location and presence of natural resources. Taking into account these factors, Kazakhstan has certain claims on leadership in the region. At the moment, Kazakhstani geopolitical leadership is based on economic achievements of the country and its political stability. At the same time demographic factor is quite sensitive from the strategic point of view. Kazakhstani population is relatively inconsiderable in number for its region. Moreover, some negative tendencies of distribution of population and its structural changes are causing concern. The government is aware of the gravity of these problems and is making certain efforts to change the situation. Nevertheless, it is very important to acknowledge the demographic factor as strategically important.
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