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Perceptions of climate change and environmental migration in Kenya: the analysis of Afrobarometer data
Přikryl, Šimon ; Hasman, Jiří (advisor) ; Masná, Eliška (referee)
Abstracts: Climate migration is one of the most discussed topics in political, media, and public discourse. In recent years, there has been a major paradigm shift in climate migration research. Increasingly, there has been a move away from "top-down" approaches using climatological and meteorological data, with the predictions of these analyses often overestimating the importance of climate in migration decision-making, to a so-called "bottom-up" approach dealing with climate perceptions and subjective factors entering the migration decision- making process. This bachelor thesis is mainly based on the latter paradigm and deals with the complex relationships between key factors (variables) entering into the individual migration decision-making process. It also examines regional variations in these variables within Kenyan provinces. The research findings, based on the statistical analysis of data for 1,600 respondents from the Afrobarometer organization, support the presumption that examining subjective perceptions of environmental change is vital in environmental and climate migration research, and that a number of socio-economic characteristics enter the migration decision-making process in the context of the climate migration. Keywords: Kenya; climate perception; climate change; migration; sub-Saharan Africa
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Glycolytic enzymes and their inhibition in cancer cell invasiveness
Martinková, Eliška ; Peltanová, Barbora (advisor) ; Raudenská, Martina (referee)
Glycolysis, an essential metabolic pathway, serves to obtain energy from glucose. All ten enzymes, which are part of the glycolytic pathway, may be involved in processes that influence migration and the ability of tumor cells to invade surrounding tissues, which is closely related to the formation of metastases. Since the majority of patients with diagnosed solid tumors die because of complications associated with primary tumor metastases, studying this phenomenon is of great interest. The purpose of this thesis is to summarize the findings on the relationship between glycolytic enzymes and tumor cell invasion. Diverse roles of enzymes related to invasion, migration and metastases are described herein, ranging from influencing angiogenesis, cytoskeleton formation and mRNA and protein stabilization to affecting various signal cascades. Room is devoted not only to the relevant mechanisms at the molecular level but also to the results of research focused on therapy to date. The thesis also provides an overview of selected inhibitors of glycolytic enzymes that affect tumor cells invasion. Key words: invasion, migration, metastasis, glycolytic enzymes, inhibition, EMT, Warburg effect
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Susceptibility of European vector species to leishmaniases spreading into Europe.
Hošková, Anna ; Sádlová, Jovana (advisor) ; Kodym, Petr (referee)
The first part of this thesis is focused on testing the ability of selected European sand fly species to support the development of Leishmania major, L. donovani and L. martiniquensis. A total of 15 experimental infections were performed and 1601 female sand flies were analysed. The results show that Phlebotomus perniciosus and P. tobbi support development of L. major and L. donovani (mature infections with colonization of the stomodeal valve and metacyclic promastigotes developed), while L. martiniquensis did not survive defecation. The vector competence of Sergentomyia minuta to Leishmania could not be tested because the females of this species refused to take blood meal on feeders, although several types of membranes, blood and experimental conditions were tested. Further, biting midges were studied in two areas of Czech equine autochthonous cases of L. martiniquensis. A total of 3341 bloodfed and parous females from Slatiňany and 119 from Ústí n. L. were analysed. The most abundant were biting midges from the Culicoides obsoletus complex. None of the 97 pools were positive for Leishmania DNA, but in 15 pools from Slatiňany was detected DNA of Herpetomonas ztiplika and one pool from Ústí n. L. contained DNA of Trypanosoma sp. from T. theileri group. The isolation of L. martiniquensis was...
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Methodology for setting firewall rules
Vagner, Michal ; Jan,, Burian (referee) ; Sedlák, Petr (advisor)
This diploma thesis focuses on explaining the concept of firewalls, and especially next-generation firewalls. It introduces their specific representative Barracuda CloudGen Firewall, project management and technologies such as Python and RESTful API. Based on these findings it creates an implementation proposal for migrating and creating firewall policies on Barracuda CloudGen Firewall in COMGUARD a.s.
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Employment of foreigners in the Czech Republic
MUSIL, Tomáš
This thesis deals with the employment of foreigners in the Czech Republic. It characterizes the legal setting in the current legislation and the historical development of the topic of foreigners in the Czech Republic. The thesis reflects the economic situation of the last few years influenced by the very low unemployment rate in the Czech Republic, but also by the current political situation caused by the Russian invasion of Ukraine and the related refugee crisis towards the EU. The method of conducting the research consisted of a questionnaire survey with domestic employers, together with a guided interview with the HR director, who is also a former foreigner. The data collected through the questionnaires and other secondary data were used for descriptive statistics and to validate the research questions using independence test and time series analysis.
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Dynamics of Residential Differentiation and Segregation of Foreigners in Czech Metropolitan Areas
Klsák, Adam ; Ouředníček, Martin (advisor) ; Čermák, Zdeněk (referee) ; Uherek, Zdeněk (referee)
Czechia has become a noteworthy case study of international migration within Central and Eastern Europe. With a steadily increasing inflow of international migrants, it is anticipated that their contribution to the societal and urban dynamics will become more pronounced. This influx has led to a rise in socio-economic and ethnic heterogeneity, reflected in spatial patterns where distinctive population groups are localized. The expe- riences from traditional immigration countries indicate that the voluntary concentration of foreigners into ethnic enclaves often serves as an intermediary phase in the integration process. However, it can also pose significant risks in situations where immigrants are not willing to participate in broader society or face exclusion. The primary goal of this dissertation is to enhance the comprehension of the spatial distribution of foreigners across selected Czech metropolitan areas and to explain the related phenomena on multiple scales within the urban hierarchy. The investigation seeks suitable data sources and methodological frameworks to analyze the current state, trajectory, determinants, and particularities of socio-spatial differentiation and segrega- tion. Furthermore, a significant focus lies in the nuanced and theoretically grounded interpretation of results,...
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Design of Part of ICT Infrastructure Migration to the Data Center
Kočíbová, Iveta ; Čada, Lukáš (referee) ; Ondrák, Viktor (advisor)
This Master Thesis deals with the design of part of ICT infrastructure migration of two sites of the international company to the external data center. It analyzes the current status of company ICT, describes the virtualization infrastructure and its operational costs. Main part of the Thesis describes a possible solution of migration of virtualization infrastructure to external data center by using project management tools and methods. Finally, the Thesis summarizes project benefits for the company.
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Study of mesenchymal stem cell migration in the extracellular matrix based on principles of chemotaxis
Scholasterová, Viktorie ; Fohlerová, Zdenka (referee) ; Chmelíková, Larisa (advisor)
This thesis engages in a study of mesenchymal stem cell migration in extracellular matrix based on principles of chemotaxis. First, attention is focused on a theoretical part associated with a clarification of basic terms such as extracellular matrix, migration, confocal microscopy, mesenchymal stem cells or chemotaxis. There is also included a list and a description of some basic methods for monitoring cell migration and a more detailed description of a method called transwell assay, which has been chosen for an experiment in a practical part of this thesis. This part includes protocols of individual steps for the preparation of the experiment, the procedure of data processing obtained by scanning cells with a confocal microscope and a description of the resulting confluence values.
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Virtual environment by Xen software
Kulíř, Tomáš ; Kouřil, Jiří (referee) ; Jelínek, Mojmír (advisor)
This bachelor thesis, which is called the virtual environment by Xen software, deals with the operating system GNU / Linux and its distributions. It also deals with the virtualization on the server or desktop computer, in particular, describes in detail the Xen environment, including all of its options and the most forgotten server services. In the first chapter is analyzed the concept of GNU / Linux. First, there is documented history. Another section deals with a brief overview of the most commonly occurring distributions. The main part of this chapter is primarily devoted to a specific distribution Debian. There is described not only the history and development of this distribution, but also more packaging system is analyzed there. The last part of this chapter is devoted to the installation options with a detailed description of the whole process step by step. Second and the most important chapter is devoted to virtual environments. Once again, there is first described their history, the possibility of practical use and the types of virtualization are also indicated there. Reader will find there a brief analysis of the most commonly used virtualization systems. The third chapter detailed deals with the Xen technology. There is not only explained the principle on which the virtualization is built, but the main part of this chapter focuses on the practical use and a summary of basic functions. The next section describes the installation and administration of hypervisor including previous preparation. A very important point is also creation of the virtual machines and their control, their migration to another physical hardware or a description of the installation of other operating systems than Linux. Fourth, shorter chapter deals with a listing and a brief description of server services. The final chapter consists of a summary of problems or complications, which in the course of this work occurred.
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