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Forming of Socialdemocratic Post-February Exile (1948-1953)
Horák, Pavel ; Čechurová, Jana (advisor) ; Burešová, Jana (referee) ; Kuklík jun., Jan (referee)
HORÁK, Pavel, Počátky poúnorového sociálnědemokratického exilu (1948-1953) [Forming of socialdemocratic post-February exile (1948-1953)], Praha, Karlova univerzita, Filozofická fakulta, Ústav českých dějin, 2014, 392 s. Vedoucí diplomové práce Doc. PhDr. Jana Čechurová, Ph.D. The study aims to answer questions in which way was formed socialdemocratic exile party in the years 1948-1953. It studies who, how and why could have or wanted to have been involved in this process. The topic is viewed from the institutional perspective of an "exile party". It analyses how was the party organised and negotiated. Besides personal stories in the background of refugee everydayness it also looks into what it meant to a be a "social democrat" in "post-February exile" and whether the "exile party" created its own sphere of communicative space for formulating program and various demands and initiatives. The work focuses on the formative period of "exile". It is delimited by the year 1953 which proved a long-term, bipolar character of the world order. The hypothesis is the statement that the "exile socialdemocratic party" was formed in the frame of Czechoslovakian post-February migration as an institution which was creating its own communication, social and migration networks based on specific criteria. At the same...
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Repatriation of Czechoslovak exile from Great Britain after the Second World War
Kučera, Jaroslav ; Čechurová, Jana (advisor) ; Horak, Pavel (referee)
The aim of this work is to present how the repatriation from the UK to the liberated Czechoslovakia took place after World War II. The inclusion of the Czechoslovak repatriation to international repatriation action is necessary to emphasize the role of international organizations without this the whole event could not be undrstood correctly. Firstly, the paper focuses on many years of planning repatriation by London exile government which was incredibly tedious process not only for itself but also for the Allies. Planning is encountered a lot of problems and in addition to some conclusions had to wait until the end of the Second World War as it was necessary to know the current situation in the home country. Secondly, the work presents itself start, progress and conclusion repatriation focusing on individual transports and difficulties that accompany them. In conclusion, the paper presents several returnees with their life stories during the duration of their stay in England and after their return to their homeland. KEY WORDS:Czechoslovakia, Exile, Repatriation, Second World War
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Evaluation and consumption of animal fat in patients with CVD and DM
Opravilová, Jana ; Vrablík, Michal (advisor) ; Horák, Pavel (referee)
The Bachelor thesis deals with the evaluation of consumption of animal fat in patients with CVD and DM. The theoretical part deals with the distribution of lipid, lipid metabolism, the quality of each animal fats, foods containing them and their cooking. The practical part consists of a questionnaire study that tracks the incidence of animal fat and method of preparation in the diet of patients with CVD and DM. Data for this study were taken at III. Internal Medicine, 1st Faculty of Medicine. Keywords Animal fats, nutrition, obesity risks
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The role of new pro-inflammatory and/or pro-fibrotic molecules in the pathogenesis of systemic sclerosis.
Tomčík, Michal ; Bečvář, Radim (advisor) ; Hrnčíř, Zbyněk (referee) ; Horák, Pavel (referee)
Introduction: Systemic sclerosis (SSc) is a generalized connective tissue disease affecting the skin and internal organs. The pathogenesis of SSc is characterized by inflammation, vasculopathy and fibrosis. To date, none of the tested drugs have demonstrated convincing efficacy in the treatment of SSc. S100A4 is involved in the regulation of cell motility, proliferation, apoptosis, angiogenesis and remodeling of the extracellular matrix. It was originally described as a promoter of metastasis in tumors, however, its pro-inflammatory properties have recently been demonstrated in inflammatory rheumatic diseases. The aim of this study was to assess the role of S100A4 in pathological activation of fibroblasts in SSc and in experimental models of dermal fibrosis. Results: The expression of S100A4 was increased in the skin of SSc patients, in SSc fibroblasts and in experimental fibrosis in a TGF-β / Smad dependent manner. Overexpression of S100A4 or stimulation with recombinant S100A4 induced an activated phenotype in resting normal fibroblasts. In contrast, inhibition of S100A4 or its complete deficit abrogated the pro-fibrotic effects of TGF-β and decreased the release of collagen. S100A4 knock-out mice (S100A4-/- ) were protected from bleomycin-induced skin fibrosis with reduced dermal thickening,...
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The role of S100 proteins in the pathogenesis of rheumatic diseases
Andrés Cerezo, Lucie ; Šenolt, Ladislav (advisor) ; Hrnčíř, Zbyněk (referee) ; Horák, Pavel (referee)
Introduction: Recent findings and better understanding to the pathogenesis of rheumatic diseases contributed to the development of biological therapies targeting cytokines and immune cells. Several S100 proteins exert cytokine-like effects and participate in the regulation of the inflammatory process. The aim of this work was to study the role of selected S100 proteins in the activity and in the pathogenesis of the rheumatic diseases. Results: Our data show for the first time an association of S100A4 proteinwith RA disease activity and decrease of the bioactive form, but not the total amount of S100A4, after aplication of tumour necrosis factor (TNF) blocking biologic therapy in patients with RA. We demonstrated that in vitro S100A4 acts as a potent pro-inflammatory mediator inducing production of TNFα, interleukin (IL)-1β and IL-6 in PBMCs via Toll-like receptor 4 (TLR-4), transcription factor NFκB and tyrosine kinases erk1/2 and p38. Moreover, S100A4 can play an important role in the pathogenesis of inflammatory myopathies. S100A4 is present in the inflammatory infiltrate of the affected muscles and in the regenerating muscles and may act as a cytokine-like factor indirectly promoting muscle fiber damage by stimulating mononuclear cells to increase the synthesis of pro-inflammatory cytokines. We...
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Application of renewable and recyclable raw materials for preparation of new polymers
Horák, Pavel ; Beneš, Hynek (advisor) ; Cajthaml, Tomáš (referee)
This thesis deals with optimalization of flexible polyurethane foam recycling with using of natural polyols based on rape seed oil and fish oil and it explores applications of depolymerized polyol product by formulations of new polyurethane materials. The experiments of depolymerisation showed that both tested natural oil (rape seed oil and fish oil) can be used as effective reagents for polyurethane recycling. Reaction conditions of depolymerisation were optimised with model flexible polyurethane foam and applied on waste foam from real conditions. Gain of depolymerisation is one-faze low viscosity (to 1500 mPa.s) liquid polyol products with content of hydroxyl groups ca 3 mmol/g. These polyols can be used for polymerisation of new materials. First application of recycled polyols was formulation of polyurethane foam systems. Through optimising of formula was prepared low-density semirigid foam containing 100 percentage of recycled polyol. Properties of these foams correspond to commercial foams. To prepare of homogenous cast polyurethane system based on recycled polyols it was necessary to add proper solvent, therefor extent of application has been lowered. On that account the systems were tested for study of polyaddition reaction and for following properties of the material. In these tests, the reactivity...
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New cytokines in the pathogenesis of rheumatic diseases
Filková, Mária ; Šenolt, Ladislav (advisor) ; Hrnčíř, Zbyněk (referee) ; Horák, Pavel (referee)
Background: An imbalance between pro- and anti- inflammatory cytokine activities favors the induction of autoimmunity, chronic inflammation and joint damage in patients with rheumatoid arthritis (RA). Adipokines are bioactive proteins that are important regulators of inflammation. IL-35 is a new cytokine involved in the inflammatory processes in mouse models and is of unknown function in humans. The aim of the work was to study the levels and role of several adipokines and IL-35 in the joint and blood compartment and the association with the disease activity in patients with RA or other rheumatic diseases. Results: We found increased levels of adiponectin in serum of patients with erosive osteoarthritis (OA) of the hand, differential regulation of new adipokines vaspin and omentin in synovial fluid of patients with RA compared with OA and the effect of therapy using TNFα inhibitor on the expression profile of adipokines in subcutaneous adipose tissue of RA patients. B cell depletion therapy in RA resulted in decrease of serum levels of visfatin that correlated with following change of disease activity. The levels of IL-35 in synovial fluid are significantly higher in RA than in OA and correlate with the disease activity and functional status. IL-35 subunits p35 and EBI3 are overexpressed in RA...
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progressive trends in energy exploitation of fossile fuels
Horák, Pavel ; Přibil, Rudolf (advisor) ; Matějíček, Luboš (referee)
This paper, as literature retrieval, evaluates progressive trends in development of technologies for energetic use of fossil fuels. The introduction is focused on reasons for increase of energetic efficiency of combustion processes, especially reasons for using of fossil fuels and their consumption over the world and in Czech Republic. Next chapter focuses on mainly used fossil fuels, which means coal, crude oil and its derivatives and natural gas. Those are evaluated in term of quality and historical progress, too. Fundamental chapter analyses particular improvements but also complex technologies used in energetic, for example using of gas turbines, assets of Kalina cycle, complex technology of Integrated Gasification Combined Cycle (IGCC), combined heat and power production (CHP), combined cycle gas turbine (CCGT) or pressurised fluid bed combustion (PFBC).
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Social demokratic publicists in the post-February exile (1948-1953)
Horák, Pavel ; Čechurová, Jana (advisor) ; Sekera, Martin (referee)
This diploma thesis (Journalism of Social Democratic Exile after February 1948 /1948- 1953/) studies the history of social democratic party in exile between the years 1948 and 1953 with special focus on journalism, news service and propaganda. The thesis describes formation of party fractions and deals with how they defined themselves, communicated and presented themselves in the media. The thesis then goes on to analyse the newspaper format, production and financing thereof as well as the number of copies. It looks into broadcasting activities of social democrats and their plans related to the setup of illegal radio. Based on the cases of party secretary Vilím Blažej and Bohumil Laušman, the last party chairman prior to February 1948, the thesis analyses the question whether single groups within the party in the given time period tried by its journalistic activities to primarily influence events in Czechoslovakia or whether these efforts slowly faded due to rivalry between fractions and frustration over hopeless political situation and lack of audience in such an extent that media outputs were later on confined only to discussions within the party and to barely expressing political views.
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The influence of some factors on renal impairment in AA amyloidosis
Potyšová, Zuzana ; Ryšavá, Romana (advisor) ; Monhart, Václav (referee) ; Horák, Pavel (referee)
Introduction: Available data suggest an association between presence of secondary (AA) amyloidosis and MCP-1 (monocyte chemoatracttant protein-1) and MIP-1alpha (macrophage inflammatory protein-1 alpha) genes polymorphisms. Some studies have also shown an impact of polymorphisms in exon 3 of SAA 1 (serum amyloid A 1) gene on the incidence of AA amyloidosis in different populations. Methods: The incidence of single genotypes MCP-1, MIP-1alpha and SAA 1 genes was investigated. Serum levels of SAA, MCP-1 and MIP-1alpha were measured and potential relation between serum levels and genotypes were analyzed. All examinations were performed in patients with AA amyloidosis (43), rheumatoid arthritis (RA) without amyloidosis and healthy control group (100). Results: Significantly more frequent occurrence of 1.1/1.1 genotype in SAA 1 was recorded in AA amyloidosis group compared to RA group as well as in control group (p<0,001). No statistically significant differences in distribution of another genotypes were found. Distribution of neither 1.1/1.1 genotype nor another ones did not vary among RA group and control group. No significant difference in distribution of another examined genotypes was recorded among all three groups. Serum concentrations of SAA were statistically significantly higher in AA amyloidosis group...
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