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Implementation of offensive standard situations in football at various performance levels
Král, Jan ; Pokorný, Ladislav (advisor) ; Krejča, Filip (referee)
The diploma thesis focuses on the implementation of offensive standard situations in football. Specifically in the competitions: division group B, third league group A and the highest competition, ie the first league. The analysis of the work is based on watching football matches from the record. The diploma thesis consists of two main sections, namely the theoretical and research section. The theoretical section is focused on theoretical concepts such as game systems, game combinations, game activities and standard situations. The research section contains the following research situations: how teams most often play offensive standard situations, from which place most offensive standard situations take place, which player most often plays offensive standard situations, from which area players most often end offensive standard situations, which player most often ends offensive standard situations, ending offensive standard situations on goal or out of goal in selected Czech football competitions, which I mentioned above. The information from the diploma thesis can be a support for coaches in the analysis of offensive standard situations of individual teams, and coaches will then be able to appropriately choose tactics in defending offensive standard situations. Keywords football, standard...
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Groundwater aggression and the impact of geological environment
Štěpán, Jiří ; Král, Jan (advisor) ; Malát, Richard (referee)
This bachelor thesis deals with groundwater aggressiveness on two sheets of detailed engineering geology maps of Prague 1:5000. The aim of this thesis is an effort to verify how much geological environment of inner Prague participates in chemical composition of groundwater. The chemical analysis were evaluated using limit values stated in valid norm ČSN EN 206 Concrete - Specification, performance, production and conformity. The chemical analysis that analyzed aggressive components (SO4 2- , CO2 a pH) and total dissolved solids discovered that the geological environment affect the chemical composition of groundwater very strongly. Groundwater in Ordovician shale commonly contains high amount of dissolved solids with a lot of sulphate. In geological environment containing quartzite, greywacke, quartz and greywacke sandstone the groundwater has small amount of dissolved solids and no aggressive component is dominant as well as too high compared to the shale.
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Engineering geology conditions of a motorway bridge over Vltava river in Prague
Polák, Zdeněk ; Král, Jan (advisor) ; Havelka, Jaroslav (referee)
Tato diplomová práce se zabývá zhodnocením inženýrskogeologických poměrů mostu na stavbě č. 519 silničního okruhu kolem Prahy včetně vyšetření stability skalních svahů v místě předpokládané výstavby. Jedná se o přemostění hlubokého erozního údolí Vltavy, na jehož svazích vystupují na povrch horniny svrchnoproterozoického stáří. Na lokalitě byly zhodnoceny pomocí rešerše archivních podkladů, vlastní rekognoskace a laboratorních zkoušek, geologické, hydrogeologické a inženýrskogeologické poměry, které jsou přehledně uvedeny v inženýrskogeologické mapě v měřítku 1:2000 a řezu 1:500. Jako podklad pro vyhodnocení stability skalních svahů sloužila podrobná dokumentace skalních výchozů. Samotné vyšetření stability proběhlo pomocí klasifikace Slope Mass Ratting a Marklandova testu pro stereografickou projekci. Na výstupech práce je souhrnně popsán horninový masiv včetně mapy stability skalních svahů v měřítku 1:500 a popsány základové poměry uvažovaného mostu.
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Diagnostic and prognostic impact of miR-122 and miR-142 in colorectal cancer
Kalkušová, Kateřina ; Červená, Klára (advisor) ; Král, Jan (referee)
Colorectal carcinoma is one of the most frequent cancers and it is also one of the most common causes of cancer related death. It is often diagnosed at a late stage which is associated with a worse prognosis. Therefore, there is an effort to identify new biomarkers that allow earlier diagnosis. These biomarkers could predict prognosis of disease and patient's response to treatment. Short noncoding RNAs - microRNA - appears to be promising candidates, these molecules are involved in many cellular processes through RNA interference. The aim of this thesis is to summarize knowledge about application of miR-122 and miR-142 as diagnostic and prognostic biomarkers for colorectal cancer. Keywords: microRNA, biomarkers, colorectal cancer, diagnostics, prognosis
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Possible approaches to the treatment of cystic fibrosis
Král, Jan ; Bořek Dohalská, Lucie (advisor) ; Nosková, Libuše (referee)
Cystic fibrosis is a genetic disease caused by a mutation in the CFTR gene. This leads to an absence or a malfunction of CFTR chloride channel, which is also a crutial regulator of other ion channels. This thesis was aimed at gene therapy of cystic fibrosis using CFTR- mRNA gene transfer. To determine the expression of CFTR protein, methods of indirect immunofluorescence and Western blot immunodetection were utilized. Also relative gene expression levels of CFTR gene were assessed by quantitative PCR. Experiments were carried out on a healthy lung epithelial cell line (NuLi-1), a lung epithelial cell line with F508del mutation (CuFi-1) and an embryonic kidney epithelial cell line (HEK293S). CFTR protein was visualized by previously mentioned methods using six primary antiobodies (432, 450, 570, 596, 769, CF3). Primary antibodies 570 a CF3 were found as optimal for the detection of CFTR protein by the method of indirect immunofluorescence, whereas for the detection of this protein by the method of Western blot only the CF3 antibody was suitable. It was also determined that CFTR gene is expressed in overall small levels. Its relative gene expression in the CuFi-1 cell line was approximately six times higher than in the NuLi-1 cell line. The efficiency of transfection of CuFi-1 cell line by CFTR-mRNA...
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Field determination of unconfined compressive strength of rocks according to ISO 14689-1
Kuře, Tomáš ; Král, Jan (advisor) ; Tábořík, Petr (referee)
Abstrakt/Summary The aim of the following bachelor thesis is to determine the strength under the uniaxial compression, according to the norm ČSN EN ISO 14689-1. This norm as replaced the norm ČSN 73 1001. Several changes in the rock classification take place in the chapter entitled The Field Determination of Strength Under Uniaxial Compression. Moreover, my own research also address the issue of rock identification and classification. The comparison of the own measurements with the data of laboratory reported in the literature results take place thorough the thesis.
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Secondary compression of Brno Tegel
Pavlová, Martina ; Boháč, Jan (advisor) ; Král, Jan (referee) ; Rozsypal, Alexandr (referee)
Observation and measurement of long-term volumetric deformation of clay are important in tackling different geotechnical and geological issues. The area of interest is the northern part of Vienna Basin, where Miocene clays sedimented. It is locally known as Brno Tegel. The Thesis deals with the secondary compression of clays, which can be defined by the Cα/Cc concept. The one-dimensional creep can be determined using the numerical values of the coefficient of secondary compression Cα and subsequently the thickness of overburden of sediments can be estimated. The two different theories, known as Hypothesis A and B are also discussed, which have been used to interpret the effect of creep during the primary consolidation phase. The laboratory measurements of long-term oedometric tests are presented for two undisturbed samples and one reconstituted sample of Brno clay. A nonstandard behaviour in uniaxial creep is also discussed, namely the observed diffusion collapse. Powered by TCPDF (www.tcpdf.org)
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