National Repository of Grey Literature 63 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Power supply for acquisition and communication subsystem of a current transformer
Beran, Tomáš ; Král, Jan (referee) ; Kubíček, Michal (advisor)
This bachelor thesis is focused on designing a power supply for measuring part and communication part of a device, which is supposed to analyze current waveforms on high voltage lines. The power supply consists of a current transformer, control electronics, and accumulation elements. The thesis analyzes the current waveforms on high voltage lines to get an overview of input data so that the right current transformer can be chosen. A working principle of these transformers is described, as well as the options for accumulation elements. Power supply requirements for the power supply are determined as well. The next part of the thesis summarises this theoretical knowledge and applies it to the schematic design. This is followed by a description of the schematic with an included description of function blocks. Additional adjustments that would improve the power supply's properties might be mentioned. This will be followed by designing a PCB layout. The final part includes the manufacturing process and determination of parameters like power, efficiency, etc. In the manufacturing process, the PCB will be printed, soldered, and evaluated on an electrical test. The electrical test inspects the functionality of the designed power supply by simulating real-life scenarios of high voltage lines. At last, an impact of the power supply on the measuring system will be analyzed.
Synthesis and biological evaluation of tacrine-amantadine derivatives
Král, Jan ; Opletalová, Veronika (advisor) ; Holas, Ondřej (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Jan Král Supervisor: doc. RNDr. Veronika Opletalová, Ph.D. Consultant: PharmDr. Jan Korábečný, Ph.D. Title of diploma thesis: Synthesis and biological evaluation of tacrine-amantadine derivatives Alzheimer's disease (AD) is a fatal neurodegenerative disorder of brain. Nowadays there is only paliative treatment available, which can be further subdivided into two groups: acetylcholinesterase inhibitors (AChEIs) and N-methyl-D-aspartate (NMDA) receptor antagonist. Donepezil, rivastigmine and galantamine represents AChEIs currently available for AD treatment. Tacrine is the first AChEIs to be approved for AD treatment, however, it was withdrawn from the market due to its side effects, especially due to its hepatotoxicity. 7-Methoxytacrine (7-MEOTA) is less toxic tacrine derivative preserving pharmacological profile of tacrine. This diploma thesis describes synthesis of multifunctional 7-MEOTA- amantadine derivatives as potential drugs to confront AD. Using Ellmanʼs method, we have established their efficacy to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro. All new synthesized hybrids from 7-MEOTA- amantadine family proved to be better...
Men of Different Faiths. Unity vs. Diversity of Antifederalism durin the Period of the Ratification of the U.S. Constitution
Král, Jan ; Raková, Svatava (advisor) ; French, William Giles (referee)
The objective oft his paper is to explore the issue of the opposition to the U.S. Constitution during the period of its ratification. The Constitution was produced by the Philadelphia Constitutional Convention of 1787 and altered the existing constitutional framework of the Articles of Confederation in many significant ways. Virtually all aspects of advocacy of the new Constitution have been thoroughly discussed in American historiography for obvious reasons: the Constitution of the United States continues to be the supreme law of the land and represents the oldest written federal constitution still in use. Powered by TCPDF (www.tcpdf.org)
Pathophysiology of colorectal cancer. Colorectal cancer screening effect and the role of microRNA in pathophysiology of colorectal cancer.
Král, Jan ; Špičák, Julius (advisor) ; Keil, Radan (referee) ; Mohelníková Duchoňová, Beatrice (referee)
Colorectal cancer is a serious malignant disease with an incidence of over 1.8 million new cases per year worldwide. There are about 8 000 patients diagnosed with CRC in the Czech Republic each year, and about half of them present with an advanced disease. Screening program identifies patients in the early stages of CRC resulting in overall better prognosis and survival. There is also a lack of biomarkers of early CRC detection and of response to treatment. The first aim of our project was to conduct a national multicentre prospective observational study to evaluate the impact of CRC screening within the framework of a Czech population screening programme. Between March 2013 and September 2015, a total of 265 patients were enrolled in 12 centres across the Czech Republic. Patients were divided into screening and control groups and compared for pathology status and clinical characteristics. Screening was defined as a primary screening colonoscopy or a colonoscopy after a positive FOBT in an average-risk population. The distribution of CRC stages was significantly favourable in the screening group compared with the control group (stages 0, I and II, 63% versus 43.3%; p <0.001). The presence of distant (M1) and local metastases (N1 and N2) was significantly less prevalent in the screening group (0%,...
Systém pro kontrolu uživatelské aktivity a jeho integrace do systému SMART fakulty
Král, Jan
The goal of this thesis is integration of a new data source into SmartPEF system. SmartPEF is the application of the concept of smart cities to the Faculty of Business and Economics of the Mendel University in Brno. As a new data source, a user activity monitoring system is being developed and implemented in order to collect statistical data about the traffic and utilization of university computers.
Diagnostic and prognostic impact of miR-122 and miR-142 in colorectal cancer
Kalkušová, Kateřina ; Červená, Klára (advisor) ; Král, Jan (referee)
Colorectal carcinoma is one of the most frequent cancers and it is also one of the most common causes of cancer related death. It is often diagnosed at a late stage which is associated with a worse prognosis. Therefore, there is an effort to identify new biomarkers that allow earlier diagnosis. These biomarkers could predict prognosis of disease and patient's response to treatment. Short noncoding RNAs - microRNA - appears to be promising candidates, these molecules are involved in many cellular processes through RNA interference. The aim of this thesis is to summarize knowledge about application of miR-122 and miR-142 as diagnostic and prognostic biomarkers for colorectal cancer. Keywords:​ microRNA, biomarkers, colorectal cancer, diagnostics, prognosis
Evaluation Of Influence Of Anti-Aliasing And Reconstruction Filters On Digital Predistortion
Král, Jan
Present wideband and spectrally-efficient communication systems require linear transmitters. As power amplifiers are naturally nonlinear, the linear transmitter is often achieved by application of a digital predistorter (DPD). DPDs require system bandwidth to be higher than communication bandwidth. We provide an evaluation of influence of the reconstruction and anti-aliasing filter on quality of predistortion process. Our results show that the generally accepted rule is too demanding and the actual required filters bandwidth is lower. This has direct impact on required sampling rates of system converters.
Thermal camera for biological applications
Macura, Jáchym ; Král, Jan (referee) ; Kubíček, Michal (advisor)
Diplomová práce se zabývá návrhem termální kamery pro biologické aplikace. V první části je popsáné infračervené záření, také známé jako thermální záření. Pokračuje popisem emisivity objektů, která hraje důležitou roli při stanovení teploty snímaného objektu. Dále je v první kapitole uveden přehled typů termálních detektorů a jejich základní vlastnosti. Druhá kapitola stručně seznamuje se zákládními hardwarovými komponenty vyvíjené kamery. V poslední kapitole je popsán celý proces vývoje softwaru. Ten zahrnuje vývoj IP jader, kernel modulů a C++ knihoven.
Engineering geological conditions of selected route cuts on the D7 highway between Prague and Louny
Kupa, Petr ; Rout, Jiří (advisor) ; Král, Jan (referee)
Engineering geological conditions of selected road cuts of the D7 highway between Prague and Louny. The aim of the thesis is to evaluate the engineering geological conditions of selected cut sections of the D7 highway and the continuing road I/7 on the track between Prague and Louny, respectively between road kilometers 9 and 49. Due to many influences, there are significant engineering geological phenomenom occurring in the line sections of line constructions, which in many cases have an adverse effect on the maintenence of road and traffic. In the framework of this thesis archive research of geological map, project and electronic materials were done, on the basis of which the general characteristic of the territory of interest were processed. Geomorphological, geological and hydrogeological conditions were described, influencing by historical mining, slope deformations and antropogenic activity were included. Field reconnaissance and geological documentation of cut sections including available outcrops were continuously conducted. General description of individual cut sections and detailed engineering geological documentation of selected sections was elaborated. Documentation also includes the processing of characteristic engineering geological sections. The results of the diploma thesis could be...

National Repository of Grey Literature : 63 records found   1 - 10nextend  jump to record:
See also: similar author names
3 KRÁL, Josef
10 Král, Jakub
1 Král, Jan (Ing.)
1 Král, Jan (RNDr.)
1 Král, Jaromír
6 Král, Jaroslav
2 Král, Jindřich
12 Král, Jiří
3 Král, Josef
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