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Evaluation of Legislative Regulations for Special Road Transport between the Czech Republic and North Europe
Kuře, Arnošt ; Novotný, Jiří (referee) ; Kudláček, Jaroslav (advisor)
he project evaluates legislative regulations for special road transport between the Czech Republic and Northern Europe. The main purpose of the project is to formulate a basic methodology for non-standard shipment’s transit. Work observes destination of the Czech Republic - Denmark, Finland, Norway and Sweden. There exist differences in legislative conditions for the particularly heavy and oversized loads transport in these countries. The main objective is to evaluate these conditions and recommend utilization for Czech carriers. The thesis aims to enumerate the various national legal standards for excessive transportation and recommend implementation outputs for correct and a quick orientation in the rights and obligations during executing carriage for the Czech carriers. The basic metodology how to transport oversized loads results from this project.
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Sewage connections to the sewer network
Novotný, Jiří ; Raček, Jakub (referee) ; Hluštík, Petr (advisor)
The Bachelor thesis comprehensively focuses on the issue of sewerage connection. The first part deals with technical sewerage connections approaches according to the applicable standards and laws. Secondary the thesis describes a procedure of furnishing sewerage connections. The following part emphasizes the steps which has do be done by a builder to get a permission from the construction authority and the operator to approved the connection. The last part compares selected city standards that clearly define the rules for a construction and an operation of the sewer system in the area.
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Forwarding bridge of bucket-wheel excavator
Zeizinger, Lukáš ; Novotný, Jiří (referee) ; Pokorný, Přemysl (advisor)
The document deals inspecting forces of the structure. The task of diploma thesis is analyze the crane load and chech up the stress of steel construction. Perform stress analysis forwarding bridge of bucket-wheel excavator by using finite element method. Further assess the consequences resulting from the design modifications. The project was carried out with cooperation with NOEN, a.s.
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Communication between PLC S7-1500 and relational database
Novotný, Jiří ; Holek, Radovan (referee) ; Štohl, Radek (advisor)
The thesis deals with the communication methods between the PLC S7-1500 and the database system and it focuses primarily on the possibilities of direct communication, i.e. without the need to use additional software. The thesis presents many of the available solutions, both commercial and freely available. Subsequently, attention is paid to the actual direct communication solution. A solution will be proposed and a~simple application will be implemented demonstrating direct communication between a~Siemens S7-1500 PLC and a Microsoft SQL Server database system. The communication is based on the TDS communication protocol. The implemented application allows direct communication with the database using basic SQL language commands. This solution is competitive with the most currently used indirect communication methods.
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Analysis of possibilities to improvement induction motors efficiency
Novotný, Jiří ; Hájek, Vítězslav (referee) ; Mach, Martin (advisor)
In the first part of the master’s thesis dealing with the increasing efficiency of induction motors there are briefly presented basic information about induction motors, followed by an overview of the losses of induction motors. The next part deals with the ways to increase efficiency of induction motors without increasing tooling costs. The practical part consists of four measurements of four induction motors, with their various mechanical adjustments to make comparing benefits of these modifications possible. The measured results are compared by a finite element method in Maxwell 2D Design program, in which the same motors are simulated as measured. Theoretical knowledge about the increase of efficiency is practically applied while being implemented in the simulations.
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Muscle noise filtering in ECG signals
Novotný, Jiří ; Kubičková, Alena (referee) ; Smital, Lukáš (advisor)
This master's thesis deals with the optimization of numerical coefficients of the Wiener filter for muscle noise filtering in ECG signals. The theoretical part deals with ECG signal characteristic and muscle interference. It also contains a summary of the wavelet transform, wavelet Wiener's filtration, methods for calculating of the threshold and thresholding. In the last theoretical part the characteristic optimization techniques, the exhausive search and Nelder-Mead simplex method are mentioned, which were implemented in the practical part of this thesis in MATLAB. The functional verification and Wiener's filter optimization were tested on the standard electrocardiograms database CSE. By using the methods of exhausive search, the initial estimate for the solution method Nelder-Mead was obtained. The optimization method Nelder-Mead gives better results in the orders of hundredths or tenths than the method of exhausive search. The practical part is finished by the comparison of results of implemented algorithm with optimum coefficients, implemented in this thesis, with the results of other methods for filtering muscle interference in ECG signals.
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Exploring the role of opioid signaling in modulation of microglial function
Mali, Akash Shivling ; Novotný, Jiří (advisor) ; Svoboda, Petr (referee) ; Machová Urdzíková, Lucia (referee)
Microglial activation is the most important component of neuroinflammation. It appears that opioids may affect microglial M1/M2 polarization in different ways depending on the type of receptor employed. In addition to opioid receptors, Toll-like receptor 4 (TLR4) of the innate immune system can also be activated by some opioid ligands and thus elicit specific cellular responses. Although opioid receptors (ORs) are known to regulate neurotransmission in various peptidergic neurons, their potential role in modulation of microglial function remains largely unknown. In this study, we investigated the effects of OR agonists, namely DAMGO, DADLE, and U-50488, on polarization and metabolic modulation of C8-B4 microglial cells. Our findings have revealed that opioids effectively suppress lipopolysaccharide (LPS)-triggered M1 polarization and promote the M2 polarization state. This was evidenced by decreased phagocytic activity, decreased production of nitric oxide (NO), diminished expression of proinflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-86, and IL-12 beta p40, along with an increased migration rate and elevated expression of anti-inflammatory markers such as IL-4, IL-10, IL-13 arginase 1, and CD206 in microglia compared to cells influenced by LPS. Furthermore, we have demonstrated that...
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Thoracic aorta wall pathology: diagnosis, stentgraft placement, indications, strategy and procedure technique, clinical results
Novotný, Jiří ; Krajina, Antonín (advisor) ; Chochola, Miroslav (referee) ; Roček, Miloslav (referee)
Thoracic aorta wall pathology: diagnosis, stentgraft placement, indications, strategy and procedure technique, clinical results Aim. Our single-center study was designed to assess management of thoracic aorta using a stent graft in individual types of pathology. While focused on the technical success rates and efficacy of management, the study also sought to document the incidence of intra- procedural complications and to assess the rate of sac growth and endoleak incidence. Method. A total of 86 patients with thoracic aorta disease were treated using a stent graft over a period of 12 years. They were 24 women and 62 men with a mean age 58.5 years. Late CT follow-up was performed in 75 patients, 31 (36%) were lost to follow-up, most (25) patients died. The most frequent reason (50%) for treatment included size of the aneurysmal sac, with progressive sac growth accounting for 19%. Results. Complications were rare, with most serious ones including 6 cases (7%) of hemorrhage, 3 fatal cases, with the other cases (peripheral bleeding) managed by a surgeon. Primarily intractable endoleak documented by DSA was observed in 9 treated patients (10%). The most frequent CT-documented endoleak was Type I endoleak diagnosed in 18 treated patients (20%). Spontaneous endoleak regression was demonstrated in 6...
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Opioid dependence: mechanisms of development of withdrawal syndrome and its treatment
Hosenseidlová, Pavla ; Novotný, Jiří (advisor) ; Ujčíková, Hana (referee)
This work deals with opioids, opioid-induced withdrawal syndrome, and its treatment. Opioids are the most commonly used analgesics in medicine, and so far, there hasn't been a better alternative for them in most health cases. However, with long-term use, dependence can develop relatively quickly, and they have a high potential for abuse. When opioid use is discontinued, withdrawal syndrome occurs, and its symptoms resemble those of the flu, including muscle and joint pain, feeling cold and having a runny nose, nausea and vomiting, diarrhea, and tachycardia. These symptoms can be very intense and are often accompanied by psychological manifestations such as anxiety and depression. The treatment of opioid withdrawal syndrome is based on alleviating both physical and psychological symptoms. Most commonly, treatment involves using opioid agonists or antagonists with accompanying therapy for psychological manifestations. It is also important to include psychotherapy in the treatment process because the addiction in many cases stems from unresolved psychological or socio-economic issues.
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Determination of opioid receptors in cerebral cortex of rats exposed to multifunctional opioid peptides
Kusová, Pavla ; Svoboda, Petr (advisor) ; Novotný, Jiří (referee)
The subject of this bachelor thesis was to study the effects of multifunctional peptides LYS739 and LYS744 on the amount of µ-, δ-, ĸ-opioid receptors (µ-OR, δ-OR, ĸ-OR) in rat cortex. Peptides were administered by the dose of 10 mg/kg for seven days. The reference group was administered a dose of 10 mg/kg morphine for the same period of the time. The effect of morphine is mainly through µ-OR. Long-term exposure to this opioid agonist results in a reduction in the function and quantity of these receptors in the development of tolerance and dependence. Multifunctional opioid peptides have begun to be investigated for their therapeutic potential to reduce adverse effects and increase efficacy. Their potential lies in their ability to interact with multiple opioid receptors. Peptides LYS739 and LYS744 act as agonists of µ-OR, δ-OR and simultaneously as antagonists of ĸ-OR. The amount of opioid receptors was determined by SDS-PAGE followed by Western blot. The results were compared with a control group that was administered by saline and a reference group that was administered by morphine. There was almost no change in the δ-OR, ĸ-OR receptors. In the case of µ-OR, there was a decrease in morphine and LYS739, but this change was not assessed as statistically significant.
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