Název: Imunitní odpověď myší na infekci žaludečními kryptosporidiemi
Překlad názvu: The immune response of mice to gastric cryptosporidium infections
Autoři: JALOVECKÁ, Marie
Typ dokumentu: Bakalářské práce
Rok: 2009
Jazyk: cze
Abstrakt: The immune response in stomach mucosa during the primary infection and re-infection of Cryptosporidium muris (TS03 and CB03) and C. andersoni in immunocompetent BALB/c mice was observed in this study. No significant differences in the induction of a cellular response were observed in mice infected with the two strains of C. muris. Significantly elevated migration of T-lymphocytes (more than 1000-fold), especially CD8+ T lymphocytes, to the stomach mucosa was described during primary infection. Moreover, the persisting severalfold increased level of T-lymphocytes in stomach epithelium was observed 2 months after recovery from the primary cryptosporidiosis. Very low level of IFN-{$\gamma$} production in ex vivo cultures of splenocytes was recorded during the course of the primary infection (0.5 ng/ml), whereas during reinfection the concentration of IFN-{$\gamma$} rapidly increased 22-fold (10.7 ng/ml). After infection of BALB/c mice with C. andersoni LI03, migration of T-lymphocytes and production of INF-{$\gamma$} in ex vivo splenocyte primary cultures was also observed, even though this isolate of C. andersoni does not infect Mus musculus. These results imply that the CD8+ T-lymphocytes are involved in the immune response to gastric cryptosporidiosis and could play an important role in the elimination of C. muris infection in mice.
Citace: JALOVECKÁ, Marie. Imunitní odpověď myší na infekci žaludečními kryptosporidiemi. České Budějovice, 2009. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Instituce: Jihočeská univerzita v Českých Budějovicích (web)
Informace o dostupnosti dokumentu: Plný text je dostupný v digitálním repozitáři JČU.
Původní záznam: http://www.jcu.cz/vskp/16058

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-86198


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Školství > Veřejné vysoké školy > Jihočeská univerzita v Českých Budějovicích
Vysokoškolské kvalifikační práce > Bakalářské práce