Original title: Real time in vivo monitoring of cytotoxic activity of two different antimicrobial peptides lasioglossin III and lasiocepsin
Authors: Tůmová, Tereza ; Lovecká, P. ; Čeřovský, Václav ; Slaninová, Jiřina
Document type: Papers
Conference/Event: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Year: 2011
Language: eng
Abstract: Real-time cell analyzer dual-plate (RTCA DP) can be used to dynamically test the cytotoxic activity of potent antimicrobial peptides. In this study, we tested the activity of two different antimicrobial peptides isolated from venom reservoirs of a wild bee against normal mammalian cell line – rat intestinal epithelial cells. The cytotoxic effect monitored by RTCA DP was expressed as IC50 and compared with the results of standard cytotoxic tests.
Keywords: cytotoxic activity; impedance based assay; Lasioglossum laticeps; real time assay
Project no.: CEZ:AV0Z40550506 (CEP), GA203/08/0536 (CEP)
Funding provider: GA ČR
Host item entry: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0204376

Permalink: http://www.nusl.cz/ntk/nusl-81033


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers