Original title: Design and synthesis of specific colevelin derivatives for in vitro and in vivo studies
Authors: Kostomoiri, M. ; Zikos, C. ; Benaki, D. ; Slaninová, Jiřina ; Pirmettis, I. ; Papadopoulos, M. ; Pelecanou, M. ; Livaniou, E.
Document type: Papers
Conference/Event: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Year: 2011
Language: eng
Abstract: Colivelin is the most potent member of the humanin family of neuroprotective peptides with in vitro and in vivo action against insults associated with Alzeimer’s Disease. The mechanism of action of colivelin is not yet elucidated. The objective of the present study is the design and synthesis of specific colivelin derivatives that can be used as molecular probes in in vitro and in vivo biological experiments. In the frame of the study three colivelin derivatives bearing suitable tags, i.e the fluorescent moiety FITC, the 99mTc-radiometal chelating unit dimethylGly-Ser-Cys, and the streptavidin-counterpart biotinyl-group, were designed and synthesized. These derivatives will be used in in vitro cell component binding and in vivo biodistribution experiments, in order to gain better insight on the mode of the neuroprotective action of colivelin.
Keywords: Alzheimer's disease; colivelin; humanin; neuroprotective peptides
Project no.: CEZ:AV0Z40550506 (CEP)
Host item entry: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0204339

Permalink: http://www.nusl.cz/ntk/nusl-81014


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers