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Original title:
In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans
Authors: Kašperová, A. ; Turánek, J. ; Čeřovský, Václav ; Raška, M.
Document type: Papers
Conference/Event: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Year: 2011
Language: eng
Abstract: Lasioglossins represent a new group of amphipathic α-helical peptides with significant antimicrobial effect on the Candida albicans. This study examines the antifungal activity of two peptides LL-III and all D-LL-III as measured by the suppression of Candida proliferation and suppression of induced morphological differentiation both in in vitro and in vivo assays. In the in vitro Candida proliferation assay, the inhibitory effect of lasioglossins LL-III and all D-LL-III was more than 70% within 24 h and more than 84% after 48 h of incubation (final concentration of either peptide was 17.5 .mu.M). Delaying of blastoconidial transition to hyphae in vitro and tendency to suppress vaginal candidiasis in experimental mice were detected.
Keywords: antimicrobial activity; Candida viability; flow cytometry analysis; vaginal candidiasis
Project no.: CEZ:AV0Z40550506 (CEP), GA203/08/0536 (CEP)
Funding provider: GA ČR
Host item entry: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9
Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0204338
Permalink: http://www.nusl.cz/ntk/nusl-81013
The record appears in these collections:
Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
Authors: Kašperová, A. ; Turánek, J. ; Čeřovský, Václav ; Raška, M.
Document type: Papers
Conference/Event: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Year: 2011
Language: eng
Abstract: Lasioglossins represent a new group of amphipathic α-helical peptides with significant antimicrobial effect on the Candida albicans. This study examines the antifungal activity of two peptides LL-III and all D-LL-III as measured by the suppression of Candida proliferation and suppression of induced morphological differentiation both in in vitro and in vivo assays. In the in vitro Candida proliferation assay, the inhibitory effect of lasioglossins LL-III and all D-LL-III was more than 70% within 24 h and more than 84% after 48 h of incubation (final concentration of either peptide was 17.5 .mu.M). Delaying of blastoconidial transition to hyphae in vitro and tendency to suppress vaginal candidiasis in experimental mice were detected.
Keywords: antimicrobial activity; Candida viability; flow cytometry analysis; vaginal candidiasis
Project no.: CEZ:AV0Z40550506 (CEP), GA203/08/0536 (CEP)
Funding provider: GA ČR
Host item entry: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9
Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0204338
Permalink: http://www.nusl.cz/ntk/nusl-81013
The record appears in these collections:
Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers
Record created 2012-01-11, last modified 2024-01-26