Original title: Lucifensin, a peptide behind the maggot therapy
Authors: Čeřovský, Václav
Document type: Papers
Conference/Event: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Year: 2011
Language: eng
Abstract: The larvae of the green bottle fly (Lucilia sericata) are routinely used as a medication for the treatment of necrotic, non-healing and highly infected wound in many hospitals all over the world. We have identified and determined primary structure of the defensin originated from the immune system of Lucilia sericata larvae and named it lucifensin. This is 40 amino acid residues and three intramolecular disulfide bridges peptide. The synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. We studied the importance of lucifensin disulfide bridges and the N-terminal part of its molecule for the structure and for antimicrobial activity.
Keywords: antimicrobial activity; disulfide bridge; lucifensin; maggot therapy; peptide synthesis
Project no.: CEZ:AV0Z40550506 (CEP), GA203/08/0536 (CEP)
Funding provider: GA ČR
Host item entry: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0204306

Permalink: http://www.nusl.cz/ntk/nusl-81008


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers