Zpětnovazebná sluchová stimulace pomalovlnného spánku: aplikace a mechanismy fungování

Urbaczka Dudysová, Daniela

Non-pharmacological manipulations of sleep represent an important tool to study the function of sleep causally. Auditory stimulation, and closed-loop auditory stimulation (CLAS) in particular, represent an innovative, easy to apply, and effective method to alter sleep. This thesis introduced our original researchinCLAS application(Study 1) and mechanisms of action (Study 2) in a chronic insomnia population for the first time. Study 1 assessed the feasibility and efficacy of CLAS for improving sleep quality and memory consolidation in chronic insomnia. This crossover, sham-controlled study involved 27 participants undergoing two nights of either CLAS or sham stimulation, monitored via polysomnography to measure sleep parameters, along with scales for assessing subjective sleep quality and a word-pair memory task for measuring overnight memory consolidation. Initial findings from 7 participants with sufficient amount of stimulations indicated that while CLAS significantly increased slow oscillation (SO) amplitude and power during slow-wave sleep, it did not alter sleep-dependent memory consolidation, overall sleep architecture, number of arousals, discrete sleep spindles, or subjective sleep quality. Additionally, Study 2 explored CLAS mechanisms with their effects on SOs on a subset of 9...

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