Je adolescence kritickým obdobím pro vznik drogové závislosti u laboratorního potkana?

Čechová, Barbora

Methamphetamine (MA) is a synthetic psychostimulant that is one of the most abused drugs in the world. It is a member of the amphetamine group, and its popularity is based on its numerous rapid-onset stimulant effects, such as increased alertness, increased energy, decreased appetite, etc. However, in the long term, this drug has very serious consequences for the mental and physical health of individuals. Long-term use of MA causes severe impairment of central nervous system (CNS) function and associated behavioral changes. By virtue of its chemical similarity to monoamine neurotransmitters, MA interacts with their respective receptors and transporters. This phenomenon causes permanent damage to the terminal endings of neurons through the development of oxidative stress, neuroinflammation, and subsequently apoptosis. Thus, MA use causes various behavioral disorders, such as depression and psychosis and contributes to the outbreak of Alzheimer's and Parkinson's diseases. The use of such drugs can have a very serious impact during critical developmental periods, which are periods in which certain parts of the brain and the whole body are undergoing intensive development. Disrupting these processes can have irreversible consequences. These drugs are very often abused by pregnant women, who starve them...

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