Vliv suplementace na utilizaci nutričních substrátů gravidních žen

Bullová, Mária

Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Mária Bullová Supervisor: PharmDr. Miroslav Kovařík, Ph.D. Title: Effect of supplementation on the utilization of nutritional substrates in pregnant woman Background The aim of this thesis was to determine and analyse changes in resting energy expenditure and substrate utilization in pregnant woman at different stages of pregnancy. Another goal of the thesis was to find an association between substrate utilization and the intake of vitamins and minerals from supplements and food. Methods The study involved 16 first-time mothers (31 ± 3years old), who were examined between the 17th -27th , 28th -35th and 36th -37th weeks of pregnancy. Resting energy expenditure and utilization of nutritional substrates were determined using indirect calorimetry and urea excretion from 24-hour urine collection. The intake of micronutrients from food and supplementation was assessed using weekly nutritional records and nutritional software Nutridan. Results Resting energy expenditure increased by approximately 20 % between the second and the end of the third trimester (p = 0.0062). It remained significantly higher even when adjusted for the percentage of predicted value (p = 0.0124), body surface area (p =...

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