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Original title:
In silico Analysis of Rutin from Ruta chalepensis.L for NF-X1 Inhibition in Cervical Cancer: Insights from HPTLC studies
Authors: Rajasekaran, Laxmipriya ; Pankaj, Vaishali ; Bhogal, Inderjeet ; Čejková, Darina
Document type: Papers
Language: eng
Publisher: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstract: Bioactive compounds play a pivotal role in the majority of pharmacological activities. Rutin, in particular, exhibits great potential in combination with antitumor drugs and various herbal formulations, enhancing permeability and regulating apoptosis induction. Earlier studies revealed the presence of alkaloids, flavonoids, phenols, quinines, and steroids among other compounds. Moreover, bioactive compounds were previously identified using GC-MS, with a total of 32 compounds identified within the plant sample Ruta chalepensis L, exhibiting several beneficial effects on leaf extract carried out through antioxidant properties. The leaves of Ruta chalepensis L were previously studied to evaluate the biological constituents and phytochemical screening. In this study, the biologically active compound was performed using high-performance thin-layer chromatography (HPTLC) plates silica gel 60 F 254, with rutin as a standard compound and methanol as a sample solvent. In cervical cancer, NF-X1 is transcriptional repressor which is highly expressed caused by HPV-associated drug compounds, was predicted to bind to rutin compound through in-silico modeling. In conclusion, it was found Rutin could be a potential modulator using molecular docking and simulation studies and has a potential therapeutic role in cervical cancer treatment.
Keywords: HPTLC; in silico; NF-X1; Ruta chalepensis. L; Rutin
Host item entry: Proceedings I of the 30st Conference STUDENT EEICT 2024: General papers, ISBN 978-80-214-6231-1, ISSN 2788-1334
Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: https://hdl.handle.net/11012/249236
Permalink: http://www.nusl.cz/ntk/nusl-622521
The record appears in these collections:
Universities and colleges > Public universities > Brno University of Technology
Conference materials > Papers
Authors: Rajasekaran, Laxmipriya ; Pankaj, Vaishali ; Bhogal, Inderjeet ; Čejková, Darina
Document type: Papers
Language: eng
Publisher: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstract: Bioactive compounds play a pivotal role in the majority of pharmacological activities. Rutin, in particular, exhibits great potential in combination with antitumor drugs and various herbal formulations, enhancing permeability and regulating apoptosis induction. Earlier studies revealed the presence of alkaloids, flavonoids, phenols, quinines, and steroids among other compounds. Moreover, bioactive compounds were previously identified using GC-MS, with a total of 32 compounds identified within the plant sample Ruta chalepensis L, exhibiting several beneficial effects on leaf extract carried out through antioxidant properties. The leaves of Ruta chalepensis L were previously studied to evaluate the biological constituents and phytochemical screening. In this study, the biologically active compound was performed using high-performance thin-layer chromatography (HPTLC) plates silica gel 60 F 254, with rutin as a standard compound and methanol as a sample solvent. In cervical cancer, NF-X1 is transcriptional repressor which is highly expressed caused by HPV-associated drug compounds, was predicted to bind to rutin compound through in-silico modeling. In conclusion, it was found Rutin could be a potential modulator using molecular docking and simulation studies and has a potential therapeutic role in cervical cancer treatment.
Keywords: HPTLC; in silico; NF-X1; Ruta chalepensis. L; Rutin
Host item entry: Proceedings I of the 30st Conference STUDENT EEICT 2024: General papers, ISBN 978-80-214-6231-1, ISSN 2788-1334
Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: https://hdl.handle.net/11012/249236
Permalink: http://www.nusl.cz/ntk/nusl-622521
The record appears in these collections:
Universities and colleges > Public universities > Brno University of Technology
Conference materials > Papers
Record created 2024-07-21, last modified 2024-07-21