Original title: Testování PLGA filmů pro lokální aplikaci kanabidiolu
Translated title: Testing of PLGA films for local delivery of cannabidiol
Authors: Juhászová, Daniela ; Šnejdrová, Eva (advisor) ; Svačinová, Petra (referee)
Document type: Master’s theses
Year: 2024
Language: slo
Abstract: [eng] [cze]
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Author: Daniela Juhászová Title of thesis: Testing of PLGA films for local delivery of cannabidiol Supervisor: PharmDr. Eva Šnejdrová, PhD. Consultant: PharmDr. Andrea Věříš The aim of the presented work was to study film forming systems for the formation of in situ films (FFS). FFS based on PLGA linear or branched architecture were formulated. The polymers were plasticized with methyl salicylate (MS) or ethyl pyruvate (EP) and incorporated with cannabidiol (CBD). Ethyl acetate, acetone and isopropanol were tested as solvents. In the theoretical section, the general characteristics of the excipients used for the FFS formulation were summarized. In the experimental section, the course of evaporation of the organic solvent from FFS and the effect of the used plasticizer were monitored. The physicochemical properties of the in situ films were characterized using DSC, the SEM method and a tensile test on a rheometer. It was concluded that the solvent evaporation time from FFS is influenced by the used plasticizer, whereas faster solvent evaporation occurred with EP plasticization. DSC showed that the incorporated cannabidiol is dissolved in the in situ film and significantly plasticizes the film. The... UNIVERZITA KARLOVA Farmaceutická fakulta v Hradci Králové Katedra farmaceutickej technológie Autor: Daniela Juhászová Názov práce: Testovanie PLGA filmov pre lokálnu aplikáciu kanabidiola Školiteľ: PharmDr. Eva Šnejdrová, PhD. Konzultant: PharmDr. Andrea Věříš Cieľom predloženej práce bolo študovať kvapalné systémy pre tvorbu in situ filmov (FFS). Boli formulované FFS na báze PLGA lineárnej alebo vetvenej štruktúry. Polyméry boli plastifikované methyl-salicylátom (MS) alebo ethyl-pyruvátom (EP) a inkorporované kanabidiolom (CBD). Ako rozpúšťadlá boli testované ethyl-acetát, acetón a isopropanol. V teoretickej časti boli zhrnuté obecné charakteristiky použitých surovín pre formuláciu FFS. V experimentálnej časti bol sledovaný priebeh odparovania organického rozpúšťadla z FFS a vplyv použitého plastifikátora. Fyzikálno-chemické vlastnosti in situ filmov boli charakterizované pomocou DSC, metódou SEM a ťahovým testom na reometri. Došlo sa k záverom, že doba evaporácie rozpúšťadiel z FFS je ovplyvnená použitým plastifikátorom, rýchlejšie odparovanie rozpúšťadla nastalo pri plastifikácii EP. DSC preukázalo, že inkorporovaný kanabidiol je v in situ filme rozpustený a film plastifikuje. Metódou SEM bola homogénna štruktúra in situ filmov potvrdená. Bola zistená výborná adhezivita in situ filmov ovplyvnená...
Keywords: film forming system; local drug delivery; in situ film; lokální aplikace léčiv

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/191861

Permalink: http://www.nusl.cz/ntk/nusl-621890


The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses